Search Results - "Locher, Matthew R."

Differential roles of regulatory light chain and myosin binding protein‐C phosphorylations in the modulation of cardiac force development by Colson, Brett A., Locher, Matthew R., Bekyarova, Tanya, Patel, Jitandrakumar R., Fitzsimons, Daniel P., Irving, Thomas C., Moss, Richard L.

“…Phosphorylation of myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK) and myosin binding protein‐C (cMyBP‐C) by protein kinase A (PKA)…”
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Protein Kinase A-Mediated Phosphorylation of cMyBP-C Increases Proximity of Myosin Heads to Actin in Resting Myocardium by Colson, Brett A, Bekyarova, Tanya, Locher, Matthew R, Fitzsimons, Daniel P, Irving, Thomas C, Moss, Richard L

“…Protein kinase A-mediated (PKA) phosphorylation of cardiac myosin binding protein C (cMyBP-C) accelerates the kinetics of cross-bridge cycling and may relieve…”
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Functional evaluation of human donation after cardiac death donor hearts using a continuous isolated myocardial perfusion technique: Potential for expansion of the cardiac donor population by Osaki, Satoru, MD, PhD, Locher, Matthew R., PhD, Lushaj, Entela B., MD, PhD, Akhter, Shahab A., MD, Kohmoto, Takushi, MD, PhD

“…Objective To investigate the resuscitation potential and contractile function in adult human donation after cardiac death (DCD) hearts by ex vivo perfusion…”
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Role of myosin heavy chain composition in the stretch activation response of rat myocardium by Stelzer, Julian E., Brickson, Stacey L., Locher, Matthew R., Moss, Richard L.

“…The speed and force of myocardial contraction during systolic ejection is largely dependent on the intrinsic contractile properties of cardiac myocytes. As the…”
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Effective Top-Down LC/MS+ Method for Assessing Actin Isoforms as a Potential Cardiac Disease Marker by Chen, Yi-Chen, Ayaz-Guner, Serife, Peng, Ying, Lane, Nicole M, Locher, Matthew R, Kohmoto, Takushi, Larsson, Lars, Moss, Richard L, Ge, Ying

“…Actin is the major component of the cytoskeleton, playing an essential role in the structure and motility of both muscle and nonmuscle cells. It is highly…”
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Effects of low-level α-myosin heavy chain expression on contractile kinetics in porcine myocardium by Locher, Matthew R, Razumova, Maria V, Stelzer, Julian E, Norman, Holly S, Moss, Richard L

“…Myosin heavy chain (MHC) isoforms are principal determinants of work capacity in mammalian ventricular myocardium. The ventricles of large mammals including…”
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Determination of rate constants for turnover of myosin isoforms in rat myocardium: implications for in vivo contractile kinetics by Locher, Matthew R, Razumova, Maria V, Stelzer, Julian E, Norman, Holly S, Patel, Jitandrakumar R, Moss, Richard L

“…The ventricles of small mammals express mostly alpha-myosin heavy chain (alpha-MHC), a fast isoform, whereas the ventricles of large mammals, including humans,…”
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Importance of myosin heavy chain isoform expression as a determinant of contraction kinetics in pig myocardium by Locher, Matthew R, Razumova, Maria V, Stelzer, Julian E, Moss, Richard L

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Effective Top-Down LC/MS plus Method for Assessing Actin Isoforms as a Potential Cardiac Disease Marker by Chen, Y-C, Ayaz-Guner, S, Peng, Y, Lane, NM, Locher, MR, Kohmoto, T, Larsson, L, Moss, RL, Ge, Y

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Differential Twitch Kinetics in Engineered Cardiac Tissue Expressing Human Cardiac Myosins by Locher, Matthew R., de Lange, Willem J., Hegge, Laura F., Grimes, Adrian C., Ralphe, John C., Moss, Richard L.

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Myosin Heavy Chain Isoform Expression and Contractile Function in Mechanically Unloaded Left Ventricles Following Left Ventricular Assist Device (LVAD) Implantation by Locher, Matthew R., Norman, Holly S., Osaki, Satoru, Kohmoto, Takushi, Sweitzer, Nancy K., Moss, Richard L.

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Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development: X-ray studies of RLC phosphorylation in skinned murine cardiac muscle by Colson, Brett A., Locher, Matthew R., Bekyarova, Tanya, Patel, Jitandrakumar R., Fitzsimons, Daniel P., Irving, Thomas C., Moss, Richard L.

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Reduced Expression of Alpha MHC in Failing, Pre-LVAD Human Myocardium Contributes to Depressed Rates of ATP Utilization by Locher, Matthew R., Norman, Holly S., Kohmoto, Takushi, Sweitzer, Nancy K., Moss, Richard L.

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Regional Nonuniformity of Contraction in the Left Ventricular Free-wall by Norman, Holly S., Maes, Margaret E., Locher, Matthew R., Patel, Jitandrakumar R., Moss, Richard L.

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Constitutive Phosphorylation of Cardiac Myosin Binding Protein-C Increases the Probability of Myosin Cross-bridge Interaction with Actin by Colson, Brett A., Bekyarova, Tanya, Locher, Matthew R., Tong, Carl W., Fitzsimons, Daniel P., Powers, Patricia A., Irving, Thomas C., Moss, Richard L.

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WITHDRAWN: Importance of myosin heavy chain isoform expression as a determinant of contraction kinetics in pig myocardium by Locher, Matthew R., Razumova, Maria V., Stelzer, Julian E., Moss, Richard L.

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Effect of low-level α myosin heavy chain expression on contractile function in mammalian myocardium by Locher, Matthew R

“…Heart failure is associated with decreased rates of force development and relaxation as well as depressed myocardial twitch force, and these alterations are…”
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