Search Results - "Locatelli, Paola"

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis by Cavallin, Lucas E, Ma, Qi, Naipauer, Julian, Gupta, Sachin, Kurian, Mani, Locatelli, Paola, Romanelli, Paolo, Nadji, Mehrdad, Goldschmidt-Clermont, Pascal J, Mesri, Enrique A

“…Kaposi's sarcoma (KS) herpesvirus (KSHV) causes KS, an angiogenic AIDS-associated spindle-cell neoplasm, by activating host oncogenic signaling cascades…”
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Promoting early neovascularization by allotransplanted adipose-derived Muse cells in an ovine model of acute myocardial infarction by Castillo, Martha G, Peralta, Tomás M, Locatelli, Paola, Velazquez, Candela, Herrero, Yamila, Crottogini, Alberto J, Olea, Fernanda D, Cuniberti, Luis A

“…Recent preclinical studies have demonstrated that bone marrow (BM)-derived Muse cells have a homing mechanism to reach damaged cardiac tissue while also being…”
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Targeting the Cardiomyocyte Cell Cycle for Heart Regeneration by Locatelli, Paola, Giménez, Carlos Sebastián, Vega, Martín Uranga, Crottogini, Alberto, Belaich, Mariano Nicolás

“…Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity leads to an increase in DNA content, but mitosis and…”
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Effect of Intramyocardial Administration of Baculovirus Encoding the Transcription Factor Tbx20 in Sheep With Experimental Acute Myocardial Infarction by Del Bauzá, María Rosario, López, Ayelén Emilce, Simonin, Jorge Alejandro, Cimbaro, Francisco Stefano, Scharn, Agustina, Castro, Araceli, Silvestro, Cintia Virginia, Cuniberti, Luis Alberto, Crottogini, Alberto José, Belaich, Mariano Nicolás, Locatelli, Paola, Olea, Fernanda Daniela

“…Gene therapy has been proposed as a strategy to induce cardiac regeneration following acute myocardial infarction (AMI). Given that Tbx20, a transcription…”
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In silico performance analysis of web tools for CRISPRa sgRNA design in human genes by Nuñez Pedrozo, Cristian N., Peralta, Tomás M., Olea, Fernanda D., Locatelli, Paola, Crottogini, Alberto J., Belaich, Mariano N., Cuniberti, Luis A.

“…Angiogenic gene overexpression has been the main strategy in numerous vascular regenerative gene therapy projects. However, most have failed in clinical…”
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Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia‐Inducible Factor 1‐α (HIF1‐α) in an Ovine Model of Acute Myocardial Infarction by Hnatiuk, Anna P., Ong, Sang‐Ging, Olea, Fernanda D., Locatelli, Paola, Riegler, Johannes, Lee, Won Hee, Jen, Cheng Hao, De Lorenzi, Andrea, Giménez, Carlos S., Laguens, Rubén, Wu, Joseph C., Crottogini, Alberto

“…Background Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic…”
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Gene Therapy: Targeting Cardiomyocyte Proliferation to Repopulate the Ischemic Heart by López, Ayelén Emilce, Bauzá, María del Rosario, Cuniberti, Luis, Crottogini, Alberto José, Olea, Fernanda Daniela, Locatelli, Paola

“…Adult mammalian cardiomyocytes show scarce division ability, which makes the heart ineffective in replacing lost contractile cells after ischemic…”
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Novel insights into cardiac regeneration based on differential fetal and adult ovine heart transcriptomic analysis by Locatelli, Paola, Belaich, Mariano N, López, Ayelén E, Olea, Fernanda D, Uranga Vega, Martín, Giménez, Carlos S, Simonin, Jorge Alejandro, Bauzá, María Del Rosario, Castillo, Marta G, Cuniberti, Luis A, Crottogini, Alberto, Cerrudo, Carolina S, Ghiringhelli, Pablo D

“…The adult mammalian cardiomyocyte has a very limited capacity to reenter the cell cycle and advance into mitosis. Therefore, diseases characterized by lost…”
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Effect of intramuscular baculovirus encoding mutant hypoxia-inducible factor 1-alpha on neovasculogenesis and ischemic muscle protection in rabbits with peripheral arterial disease by Giménez, Carlos S., Castillo, Martha G., Simonin, Jorge A., Núñez Pedrozo, Cristian N., Pascuali, Natalia, Bauzá, María del Rosario, Locatelli, Paola, López, Ayelén E., Belaich, Mariano N., Mendiz, Alfredo O., Crottogini, Alberto J., Cuniberti, Luis A., Olea, Fernanda D.

“…Peripheral arterial disease (PAD) is a progressive, disabling ailment for which no effective treatment exists. Gene therapy-mediated neovascularization has…”
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Vascular Endothelial Growth Factor Overexpression Does Not Enhance Adipose Stromal Cell–Induced Protection on Muscle Damage in Critical Limb Ischemia by Olea, Fernanda Daniela, Locatelli, Paola, Hnatiuk, Anna, De Lorenzi, Andrea, Valdivieso, León, Rocha, Estefanía, Ramírez, Rodrigo, Laguens, Rubén, Crottogini, Alberto

“…OBJECTIVES—Critical limb ischemia complicates peripheral artery disease leading to tissue damage and amputation. We hypothesized that modifying adipose stromal…”
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High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction by Bauzá, María del Rosario, Giménez, Carlos Sebastián, Locatelli, Paola, De Lorenzi, Andrea, Hnatiuk, Anna, Capogrossi, Maurizio C., Crottogini, Alberto, Cuniberti, Luis, Olea, Fernanda Daniela

“…In rodents with acute myocardial infarction (AMI), high mobility group box 1 (HMGB1) injection has produced controversial results. Given the lack of data in…”
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Aligned ovine diaphragmatic myoblasts overexpressing human connexin-43 seeded on poly (l-lactic acid) scaffolds for potential use in cardiac regeneration by Giménez, Carlos Sebastián, Locatelli, Paola, Montini Ballarin, Florencia, Orlowski, Alejandro, Dewey, Ricardo A., Pena, Milagros, Abraham, Gustavo Abel, Aiello, Ernesto Alejandro, Bauzá, María del Rosario, Cuniberti, Luis, Olea, Fernanda Daniela, Crottogini, Alberto

“…Diaphragmatic myoblasts (DMs) are precursors of type-1 muscle cells displaying high exhaustion threshold on account that they contract and relax 20 times/min…”
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Effect of poly (l-lactic acid) scaffolds seeded with aligned diaphragmatic myoblasts overexpressing connexin-43 on infarct size and ventricular function in sheep with acute coronary occlusion by Giménez, Carlos Sebastián, Olea, Fernanda Daniela, Locatelli, Paola, Dewey, Ricardo A, Abraham, Gustavo Abel, Montini Ballarin, Florencia, Bauzá, Maria Del Rosario, Hnatiuk, Anna, De Lorenzi, Andrea, Neira Sepúlveda, Ángela, Embon, Mario, Cuniberti, Luis, Crottogini, Alberto

“…Diaphragmatic myoblasts (DM) are stem cells of the diaphragm, a muscle displaying high resistance to stress and exhaustion. We hypothesized that DM modified to…”
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Efficient plasmid-mediated gene transfection of ovine bone marrow mesenchymal stromal cells by Locatelli, Paola, Olea, Fernanda Daniela, Hnatiuk, Anna, Sepúlveda, Diana, Pérez Sáez, Juan Manuel, Argüello, Rafael, Crottogini, Alberto

“…Abstract Background aims Given the close similarity between ovine and human cardiomyocytes, sheep models of myocardial infarction and heart failure are…”
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Activated macrophages as a feeder layer for growth of resident cardiac progenitor cells by Sepúlveda, Diana E., Cabeza Meckert, Patricia, Locatelli, Paola, Olea, Fernanda D., Pérez, Néstor G., Pinilla, Oscar A., Díaz, Romina G., Crottogini, Alberto, Laguens, Rubén P.

“…The adult heart contains a population of cardiac progenitor cells (CPCs). Growing and collecting an adequate number of CPCs demands complex culture media…”
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Combined VEGF gene transfer and erythropoietin in ovine reperfused myocardial infarction by Olea, Fernanda D, De Lorenzi, Andrea, Cortés, Claudia, Cuniberti, Luis, Fazzi, Lucía, Flamenco, María del Pilar, Locatelli, Paola, Cabeza Meckert, Patricia, Bercovich, Andrés, Laguens, Rubén, Crottogini, Alberto

“…Abstract Background In reperfused acute myocardial infarction (RAMI), cardioprotective treatments may enhance myocardial salvage and hence reduce the area of…”
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An ovine model of postinfarction dilated cardiomyopathy in animals with highly variable coronary anatomy by Locatelli, Paola, Olea, Fernanda D, Mendiz, Oscar, Salmo, Fabián, Fazzi, Lucía, Hnatiuk, Anna, Laguens, Rubén, Crottogini, Alberto

“…Studies on cardiac regeneration require large mammalian models of dilated cardiomyopathy (DCM) after acute myocardial infarction (AMI), and pig and sheep…”
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Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans by Locatelli, Paola, Olea, Fernanda D, De Lorenzi, Andrea, Salmo, Fabián, Vera Janavel, Gustavo L, Hnatiuk, Anna P, Guevara, Eduardo, Crottogini, Alberto J

“…Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However, reliable extrapolation of the results to…”
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