Search Results - "Locatelli, Franco"

Introduction. Immunotherapy for childhood malignancies: the future is now by Locatelli, Franco

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How I treat myelodysplastic syndromes of childhood by Locatelli, Franco, Strahm, Brigitte

“…Pediatric myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal disorders with an annual incidence of 1 to 4 cases per million, accounting for…”
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Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications by Nazio, Francesca, Bordi, Matteo, Cianfanelli, Valentina, Locatelli, Franco, Cecconi, Francesco

“…Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions strictly depend on cancer ontogenesis, progression, and type. For…”
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How I treat juvenile myelomonocytic leukemia by Locatelli, Franco, Niemeyer, Charlotte M.

“…Juvenile myelomonocytic leukemia (JMML) is a unique, aggressive hematopoietic disorder of infancy/early childhood caused by excessive proliferation of cells of…”
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Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses by Raoult, Didier, Zumla, Alimuddin, Locatelli, Franco, Ippolito, Giuseppe, Kroemer, Guido

“…Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome…”
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Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host Disease by Zeiser, Robert, Polverelli, Nicola, Ram, Ron, Hashmi, Shahrukh K, Chakraverty, Ronjon, Middeke, Jan Moritz, Musso, Maurizio, Giebel, Sebastian, Uzay, Ant, Langmuir, Peter, Hollaender, Norbert, Gowda, Maanasa, Stefanelli, Tommaso, Lee, Stephanie J, Teshima, Takanori, Locatelli, Franco

“…Standard treatment for GVHD is glucocorticoids, but for glucocorticoid-refractory GVHD, no intervention has emerged as standard second-line treatment. This…”
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Inhibition of Natural Killer Cell Cytotoxicity by Interleukin‐6: Implications for the Pathogenesis of Macrophage Activation Syndrome by Cifaldi, Loredana, Prencipe, Giusi, Caiello, Ivan, Bracaglia, Claudia, Locatelli, Franco, De Benedetti, Fabrizio, Strippoli, Raffaele

“…Objective Systemic juvenile idiopathic arthritis (JIA) is associated with high levels of interleukin‐6 (IL‐6) in the serum and synovial fluid, and impairment…”
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Allogeneic chimeric antigen receptor T cells for children with relapsed/refractory B-cell precursor acute lymphoblastic leukemia by Locatelli, Franco, Del Bufalo, Francesca, Quintarelli, Concetta

“…Chimeric antigen receptor (CAR) T-cell therapy has emerged as a breakthrough cancer therapy over the past decade. Remarkable outcomes in B-cell…”
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How I treat relapsed childhood acute lymphoblastic leukemia by Locatelli, Franco, Schrappe, Martin, Bernardo, Maria Ester, Rutella, Sergio

“…The most common cause of treatment failure in childhood acute lymphoblastic leukemia (ALL) remains relapse, occurring in ∼ 15%-20% of patients. Survival of…”
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Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation by Pende, Daniela, Falco, Michela, Vitale, Massimo, Cantoni, Claudia, Vitale, Chiara, Munari, Enrico, Bertaina, Alice, Moretta, Francesca, Del Zotto, Genny, Pietra, Gabriella, Mingari, Maria Cristina, Locatelli, Franco, Moretta, Lorenzo

“…Natural killer (NK) cells contribute to the first line of defense against viruses and to the control of tumor growth and metastasis spread. The discovery of…”
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The Immune Response to SARS-CoV-2 Vaccination: Insights Learned From Adult Patients With Common Variable Immune Deficiency by Quinti, Isabella, Locatelli, Franco, Carsetti, Rita

“…CVID patients have an increased susceptibility to vaccine-preventable infections. The question on the potential benefits of immunization of CVID patients…”
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HLA allele frequencies and susceptibility to COVID‐19 in a group of 99 Italian patients by Novelli, Antonio, Andreani, Marco, Biancolella, Michela, Liberatoscioli, Laura, Passarelli, Chiara, Colona, Vito Luigi, Rogliani, Paola, Leonardis, Francesca, Campana, Andrea, Carsetti, Rita, Andreoni, Massimo, Bernardini, Sergio, Novelli, Giuseppe, Locatelli, Franco

“…With the aim to individuate alleles that may reflect a higher susceptibility to the disease, in the present study we analyzed the HLA allele frequency…”
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ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion by Cesarini, Valeriana, Silvestris, Domenico A, Tassinari, Valentina, Tomaselli, Sara, Alon, Shahar, Eisenberg, Eli, Locatelli, Franco, Gallo, Angela

“…Abstract Recent studies have reported the emerging role of microRNAs (miRNAs) in human cancers. We systematically characterized miRNA expression and editing in…”
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Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study by Grasselli, Giacomo, Tonetti, Tommaso, Protti, Alessandro, Langer, Thomas, Girardis, Massimo, Bellani, Giacomo, Laffey, John, Carrafiello, Gianpaolo, Carsana, Luca, Rizzuto, Chiara, Zanella, Alberto, Scaravilli, Vittorio, Pizzilli, Giacinto, Grieco, Domenico Luca, Di Meglio, Letizia, de Pascale, Gennaro, Lanza, Ezio, Monteduro, Francesco, Zompatori, Maurizio, Filippini, Claudia, Locatelli, Franco, Cecconi, Maurizio, Fumagalli, Roberto, Nava, Stefano, Vincent, Jean-Louis, Antonelli, Massimo, Slutsky, Arthur S, Pesenti, Antonio, Ranieri, V Marco, Lissoni, Alfredo, Rossi, Nicola, Guzzardella, Amedeo, Valsecchi, Carlo, Madotto, Fabiana, Bevilacqua, Francesca, Di Laudo, Marco, Querci, Lorenzo, Seccafico, Carmen

“…Patients with COVID-19 can develop acute respiratory distress syndrome (ARDS), which is associated with high mortality. The aim of this study was to examine…”
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Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study by Peters, Christina, Dalle, Jean-Hugues, Locatelli, Franco, Poetschger, Ulrike, Sedlacek, Petr, Buechner, Jochen, Shaw, Peter J, Staciuk, Raquel, Ifversen, Marianne, Pichler, Herbert, Vettenranta, Kim, Svec, Peter, Aleinikova, Olga, Stein, Jerry, Güngör, Tayfun, Toporski, Jacek, Truong, Tony H, Diaz-de-Heredia, Cristina, Bierings, Marc, Ariffin, Hany, Essa, Mohammed, Burkhardt, Birgit, Schultz, Kirk, Meisel, Roland, Lankester, Arjan, Ansari, Marc, Schrappe, Martin, von Stackelberg, Arend, Balduzzi, Adriana, Corbacioglu, Selim, Bader, Peter

“…Total body irradiation (TBI) before allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is…”
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ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism by Tassinari, Valentina, Cesarini, Valeriana, Tomaselli, Sara, Ianniello, Zaira, Silvestris, Domenico Alessandro, Ginistrelli, Lavinia Ceci, Martini, Maurizio, De Angelis, Biagio, De Luca, Gabriele, Vitiani, Lucia Ricci, Fatica, Alessandro, Locatelli, Franco, Gallo, Angela

“…N -methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing are two of the most abundant RNA modification events affecting adenosines in mammals…”
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Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry by Cetica, Valentina, PhD, Sieni, Elena, MD, Pende, Daniela, PhD, Danesino, Cesare, MD, De Fusco, Carmen, MD, Locatelli, Franco, MD, Micalizzi, Concetta, MD, Putti, Maria Caterina, MD, Biondi, Andrea, MD, Fagioli, Franca, MD, Moretta, Lorenzo, MD, Griffiths, Gillian M., PhD, Luzzatto, Lucio, MD, Aricò, Maurizio, MD

“…Background Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease affecting mostly children but also adults and characterized by…”
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Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma by Melaiu, Ombretta, Chierici, Marco, Lucarini, Valeria, Jurman, Giuseppe, Conti, Libenzio Adrian, De Vito, Rita, Boldrini, Renata, Cifaldi, Loredana, Castellano, Aurora, Furlanello, Cesare, Barnaba, Vincenzo, Locatelli, Franco, Fruci, Doriana

“…Tumor-infiltrating lymphocytes play an essential role in improving clinical outcome of neuroblastoma (NB) patients, but their relationship with other…”
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Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study by Barzaghi, Federica, Amaya Hernandez, Laura Cristina, Neven, Benedicte, Ricci, Silvia, Kucuk, Zeynep Yesim, Bleesing, Jack J., Nademi, Zohreh, Slatter, Mary Anne, Ulloa, Erlinda Rose, Shcherbina, Anna, Roppelt, Anna, Worth, Austen, Silva, Juliana, Aiuti, Alessandro, Murguia-Favela, Luis, Speckmann, Carsten, Carneiro-Sampaio, Magda, Fernandes, Juliana Folloni, Baris, Safa, Ozen, Ahmet, Karakoc-Aydiner, Elif, Kiykim, Ayca, Schulz, Ansgar, Steinmann, Sandra, Notarangelo, Lucia Dora, Gambineri, Eleonora, Lionetti, Paolo, Shearer, William Thomas, Forbes, Lisa R., Martinez, Caridad, Moshous, Despina, Blanche, Stephane, Fisher, Alain, Ruemmele, Frank M., Tissandier, Come, Ouachee-Chardin, Marie, Rieux-Laucat, Frédéric, Cavazzana, Marina, Qasim, Waseem, Lucarelli, Barbarella, Albert, Michael H., Kobayashi, Ichiro, Alonso, Laura, Diaz De Heredia, Cristina, Kanegane, Hirokazu, Lawitschka, Anita, Seo, Jong Jin, Gonzalez-Vicent, Marta, Diaz, Miguel Angel, Goyal, Rakesh Kumar, Sauer, Martin G., Yesilipek, Akif, Kim, Minsoo, Yilmaz-Demirdag, Yesim, Bhatia, Monica, Khlevner, Julie, Richmond Padilla, Erick J., Martino, Silvana, Montin, Davide, Neth, Olaf, Molinos-Quintana, Agueda, Valverde-Fernandez, Justo, Broides, Arnon, Pinsk, Vered, Ballauf, Antje, Haerynck, Filomeen, Bordon, Victoria, Dhooge, Catharina, Garcia-Lloret, Maria Laura, Bredius, Robbert G., Kałwak, Krzysztof, Haddad, Elie, Seidel, Markus Gerhard, Duckers, Gregor, Pai, Sung-Yun, Dvorak, Christopher C., Ehl, Stephan, Locatelli, Franco, Goldman, Frederick, Gennery, Andrew Richard, Cowan, Mort J., Roncarolo, Maria-Grazia, Bacchetta, Rosa

“…Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a monogenic autoimmune disease caused by FOXP3 mutations. Because it is a rare…”
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Modeling medulloblastoma in vivo and with human cerebellar organoids by Ballabio, Claudio, Anderle, Marica, Gianesello, Matteo, Lago, Chiara, Miele, Evelina, Cardano, Marina, Aiello, Giuseppe, Piazza, Silvano, Caron, Davide, Gianno, Francesca, Ciolfi, Andrea, Pedace, Lucia, Mastronuzzi, Angela, Tartaglia, Marco, Locatelli, Franco, Ferretti, Elisabetta, Giangaspero, Felice, Tiberi, Luca

“…Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in…”
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