Search Results - "Locardi, Elsa"

Carbohydrate-Based Mimetics in Drug Design:  Sugar Amino Acids and Carbohydrate Scaffolds by Gruner, Sibylle A. W, Locardi, Elsa, Lohof, Elisabeth, Kessler, Horst

“…Gruner et al review the synthesis of sugar amino acids (SAAs), their incorporation in peptidic or saccharidic structures, and their potential use in medicinal…”
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Design, Synthesis, and NMR Structure of Linear and Cyclic Oligomers Containing Novel Furanoid Sugar Amino Acids by Gruner, Sibylle A. W., Truffault, Vincent, Voll, Georg, Locardi, Elsa, Stöckle, Matthias, Kessler, Horst

“…Sugar Amino Acids (SAAs) are sugar moieties containing at least one amino and one carboxyl group. The straightforward synthesis of two furanoid SAAs,…”
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TREN (Tris(2-aminoethyl)amine):  An Effective Scaffold for the Assembly of Triple Helical Collagen Mimetic Structures by Kwak, Juliann, Capua, Antonia De, Locardi, Elsa, Goodman, Murray

“…A new scaffold, TREN-(suc-OH)3 where TREN is tris(2-aminoethyl)amine and suc is the succinic acid spacers, was incorporated to assemble triple helices composed…”
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Synthesis and Structure−Activity Relationship of Mannose-Based Peptidomimetics Selectively Blocking Integrin α4β7 Binding to Mucosal Addressin Cell Adhesion Molecule-1 by Locardi, Elsa, Boer, Jürgen, Modlinger, Armin, Schuster, Anja, Holzmann, Bernhard, Kessler, Horst

“…As part of our ongoing research in the development of α4β7 integrin antagonists, we are interested in peptidomimetics based on a rigid scaffold to allow the…”
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Thermodynamics of Formation of the Triple Helix from Free Chains and from Template-Constrained Chains of Collagen-like Monodisperse Poly(Gly-Pro-Hyp) Structures by Locardi, Elsa, Kwak, Juliann, Scheraga, Harold A, Goodman, Murray

“…Statistical thermodynamic methods, developed for treating the α-helix−coil transition, are applied herein to describe the formation of the triple helix from…”
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Novel Small Molecule Bradykinin B 2 Receptor Antagonists by Gibson, Christoph, Schnatbaum, Karsten, Pfeifer, Jochen R., Locardi, Elsa, Paschke, Matthias, Reimer, Ulf, Richter, Uwe, Scharn, Dirk, Faussner, Alexander, Tradler, Thomas

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Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: Increased receptor specificity and in vivo activity by Schnatbaum, Karsten, Locardi, Elsa, Scharn, Dirk, Richter, Uwe, Hawlisch, Heiko, Knolle, Jochen, Polakowski, Thomas

“…New C5a receptor antagonists characterized by C-terminal amino acids with hydrophobic substitutions are presented. A new class of peptidomimetic C5a receptor…”
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Novel Small Molecule Bradykinin B2 Receptor Antagonists by Gibson, Christoph, Schnatbaum, Karsten, Pfeifer, Jochen R, Locardi, Elsa, Paschke, Matthias, Reimer, Ulf, Richter, Uwe, Scharn, Dirk, Faussner, Alexander, Tradler, Thomas

“…Blockade of the bradykinin B2 receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe…”
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Cyclic Homooligomers from Sugar Amino Acids:  Synthesis, Conformational Analysis, and Significance by Locardi, Elsa, Stöckle, Matthias, Gruner, Sibylle, Kessler, Horst

“…Sugar amino acids (SAAs) were designed as new building blocks carrying an amino group and a carboxyl group on a carbohydrate scaffold. By exploiting standard…”
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M1659 Bradykinin 1 Receptor Inhibition Has Strong Anti-Inflammatory Effects in Chronic Experimental Colitis by Hofmann, Claudia, Dunger, Nadja, Grunwald, Nicole, Scholmerich, Jurgen, Falk, Werner, Locardi, Elsa, Dinkel, Klaus, Obermeier, Florian

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Novel small molecule bradykinin B 1 receptor antagonists. Part 1: Benzamides and semicarbazides by Schaudt, Marco, Locardi, Elsa, Zischinsky, Gunther, Stragies, Roland, Pfeifer, Jochen R., Gibson, Christoph, Scharn, Dirk, Richter, Uwe, Kalkhof, Holger, Dinkel, Klaus, Schnatbaum, Karsten

“…Benzamides and semicarbazides are introduced as new classes of bradykinin B 1 receptor antagonists. The best compounds feature excellent pharmacokinetic…”
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Novel small molecule bradykinin B 1 receptor antagonists. Part 2: 5-membered diaminoheterocycles by Zischinsky, Gunther, Stragies, Roland, Schaudt, Marco, Pfeifer, Jochen R., Gibson, Christoph, Locardi, Elsa, Scharn, Dirk, Richter, Uwe, Kalkhof, Holger, Dinkel, Klaus, Schnatbaum, Karsten

“…New bradykinin B1 receptor antagonists based on 5-membered diaminoheterocycles with nanomolar activity are presented. Efforts to find new bradykinin B 1…”
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Novel small molecule bradykinin B 1 receptor antagonists. Part 3: Hydroxyurea derivatives by Schnatbaum, Karsten, Schaudt, Marco, Stragies, Roland, Pfeifer, Jochen R., Gibson, Christoph, Locardi, Elsa, Scharn, Dirk, Richter, Uwe, Kalkhof, Holger, Dinkel, Klaus, Zischinsky, Gunther

“…Hydroxy urea analogues have been developed as a new class of bradykinin B1 receptor antagonists. Systematic optimization led to the identification of several…”
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Novel small molecule bradykinin B sub(1) receptor antagonists. Part 1: Benzamides and semicarbazides by Schaudt, Marco, Locardi, Elsa, Zischinsky, Gunther, Stragies, Roland, Pfeifer, Jochen R, Gibson, Christoph, Scharn, Dirk, Richter, Uwe, Kalkhof, Holger, Dinkel, Klaus, Schnatbaum, Karsten

“…The synthesis and SAR of two series of bradykinin B sub(1) receptor antagonists is described. The benzamide moiety proved to be a suitable replacement for the…”
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Novel small molecule bradykinin B sub(1) receptor antagonists. Part 2: 5-membered diaminoheterocycles by Zischinsky, Gunther, Stragies, Roland, Schaudt, Marco, Pfeifer, Jochen R, Gibson, Christoph, Locardi, Elsa, Scharn, Dirk, Richter, Uwe, Kalkhof, Holger, Dinkel, Klaus, Schnatbaum, Karsten

“…Efforts to find new bradykinin B sub(1) receptor antagonists identified 2-aminobenzimidazole as a novel core. Subsequent transformation into five-membered…”
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Novel small molecule bradykinin B sub(1) receptor antagonists. Part 3: Hydroxyurea derivatives by Schnatbaum, Karsten, Schaudt, Marco, Stragies, Roland, Pfeifer, Jochen R, Gibson, Christoph, Locardi, Elsa, Scharn, Dirk, Richter, Uwe, Kalkhof, Holger, Dinkel, Klaus, Zischinsky, Gunther

“…Hydroxy urea moieties are introduced as a new class of bradykinin B sub(1) receptor antagonists. First, the SAR of the lead compound was systematically…”
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Synthesis and NMR Studies of Cyclopeptides Containing a Sugar Amino Acid by Stöckle, Matthias, Voll, Georg, Günther, Robert, Lohof, Elisabeth, Locardi, Elsa, Gruner, Sibylle, Kessler, Horst

“…Cyclopeptides containing Glucuronic acid methylamine (Gum) alternating with Gly, l-Ala, d-Ala, l-Phe, d-Phe, l-Lys, or d-Lys were synthesized by a combination…”
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Novel Small Molecule Bradykinin 82 Receptor Antagonists by GIBSON, Christoph, SCHNATBAUM, Karsten, PFEIFER, Jochen R, LOCARDI, Elsa, PASCHKE, Matthias, REIMER, Ulf, RICHTER, Uwe, SCHARN, Dirk, FAUSSNER, Alexander, TRADLER, Thomas

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Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles by ZISCHINSKY, Gunther, STRAGIES, Roland, SCHNATBAUM, Karsten, SCHAUDT, Marco, PFEIFER, Jochen R, GIBSON, Christoph, LOCARDI, Elsa, SCHARN, Dirk, RICHTER, Uwe, KALKHOF, Holger, DINKEL, Klaus

“…Efforts to find new bradykinin B(1) receptor antagonists identified 2-aminobenzimidazole as a novel core. Subsequent transformation into five-membered…”
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Novel small molecule bradykinin B1 receptor antagonists. Part 1: Benzamides and semicarbazides by SCHAUDT, Marco, LOCARDI, Elsa, SCHNATBAUM, Karsten, ZISCHINSKY, Gunther, STRAGIES, Roland, PFEIFER, Jochen R, GIBSON, Christoph, SCHARN, Dirk, RICHTER, Uwe, KALKHOF, Holger, DINKEL, Klaus

“…The synthesis and SAR of two series of bradykinin B(1) receptor antagonists is described. The benzamide moiety proved to be a suitable replacement for the aryl…”
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