Search Results - "Loc’h, Christian"

Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining by Cabello-Lobato, Maria Jose, Jenner, Matthew, Cisneros-Aguirre, Metztli, Brüninghoff, Kira, Sandy, Zac, da Costa, Isabelle C, Jowitt, Thomas A, Loch, Christian M, Jackson, Stephen P, Wu, Qian, Mootz, Henning D, Stark, Jeremy M, Cliff, Matthew J, Schmidt, Christine K

“…SUMOylation is critical for numerous cellular signalling pathways, including the maintenance of genome integrity via the repair of DNA double-strand breaks…”
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Synthesis and Biological Evaluation of Substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the Study of the Peripheral Benzodiazepine Receptor Using Positron Emission Tomography by Fookes, Christopher J. R, Pham, Tien Q, Mattner, Filomena, Greguric, Ivan, Loc’h, Christian, Liu, Xiang, Berghofer, Paula, Shepherd, Rachael, Gregoire, Marie-Claude, Katsifis, Andrew

“…The fluoroethoxy and fluoropropoxy substituted 2-(6-chloro-2-phenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-diethylacetamides 8 (PBR102) and 12 (PBR111) and…”
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Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions by Tiruppathi, Chinnaswamy, Wang, Dong-Mei, Ansari, Mohammad Owais, Bano, Shabana, Tsukasaki, Yoshikazu, Mukhopadhyay, Amitabha, Joshi, Jagdish C., Loch, Christian, Niessen, Hans W. M., Malik, Asrar B.

“…Vascular endothelial cadherin (VE-cadherin) expressed at endothelial adherens junctions (AJs) is vital for vascular integrity and endothelial homeostasis. Here…”
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Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes by Loch, Christian, Zakelj, Simon, Kristl, Albin, Nagel, Stefan, Guthoff, Rudolf, Weitschies, Werner, Seidlitz, Anne

“…Comparison of permeability coefficients of lidocaine, ciprofloxacin, timolol and dexamethasone for the cornea and a multi-layer complex of porcine, bovine and…”
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Role of ubiquitylation and USP8‐dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1 by Balut, Corina M., Loch, Christian M., Devor, Daniel C.

“…ABSTRACT We recently demonstrated that plasma membrane KCa3.1 is rapidly endocytosed and targeted for lysosomal degradation via a Rab7‐ and ESCRT‐dependent…”
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A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate by Loch, Christian M., Strickler, James E.

“…Substrate ubiquitylation is a reversible process critical to cellular homeostasis that is often dysregulated in many human pathologies including cancer and…”
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A rapid and efficient preparation of [ 123I]radiopharmaceuticals using a small HPLC (Rocket ®) column by Katsifis, Andrew, Papazian, Vahan, Jackson, Timothy, Loc’h, Christian

“…A simplified method for the rapid and efficient preparation of [ 123I]radiopharmaceuticals is described. Three radiopharmaceuticals, [ 123I] β-CIT, [ 123I]MIBG…”
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Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: a case–control study by Blume, Heidi K, Li, Christopher I, Loch, Christian M, Koepsell, Thomas D

“…In this study we examined the relationship between diagnoses of isolated intrapartum fever or chorioamnionitis and the risk of encephalopathy in term newborns…”
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Quantitation of Extrastriatal D2 Receptors Using a Very High-Affinity Ligand (FLB 457) and the Multi-Injection Approach by Delforge, Jacques, Bottlaender, Michel, Loc'h, Christian, Guenther, Ilonka, Fuseau, Chantal, Bendriem, Bernard, Syrota, André, Maziére, Bernard

“…The multi-injection approach has been used to study in baboon the in vivo interactions between the D2 receptor sites and FLB 457, a ligand with a very high…”
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Use of bromine-76 and iodine-123 radiohalogenated tracers in the drug development process by Mazière, B, Loc'h, C

“…The only bromine and iodine radioisotopes worth using in PET or SPECT in vivo investigations during the development of a new drug are 76Br and 123I. It is most…”
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Absolute Quantification by Positron Emission Tomography of the Endogenous Ligand by Delforge, Jacques, Bottlaender, Michel, Pappata, Sabina, Loc'h, Christian, Syrota, André

“…The results of several recent papers have shown a significant influence of the endogenous neurotransmitters on the exogenous ligand kinetics measured by…”
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Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance by Greguric, Ivan, Taylor, Stephen R, Denoyer, Delphine, Ballantyne, Patrice, Berghofer, Paula, Roselt, Peter, Pham, Tien Q, Mattner, Filomena, Bourdier, Thomas, Neels, Oliver C, Dorow, Donna S, Loc’h, Christian, Hicks, Rodney J, Katsifis, Andrew

“…The high melanoma uptake and rapid body clearance displayed by our series of [123I]iodonicotinamides prompted the development of…”
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Deubiquitylase, DeSUMOylase, and DeISGylase Activity Microarrays for Assay of Substrate Preference and Functional Modifiers by Loch, Christian M., Cuccherini, Charles L., Leach, Craig A., Strickler, James E.

“…Microarray-based proteomics expanded the information potential of DNA arrays to the level of protein translation and interaction, but so far, not much beyond…”
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Use of a Single-Chain Antibody Library for Ovarian Cancer Biomarker Discovery by Ramirez, Arturo B., Loch, Christian M., Zhang, Yuzheng, Liu, Yan, Wang, Xiaohong, Wayner, Elizabeth A., Sargent, Jonathon E., Sibani, Sahar, Hainsworth, Eugenie, Mendoza, Eliseo A., Eugene, Ralph, LaBaer, Joshua, Urban, Nicole D., McIntosh, Martin W., Lampe, Paul D.

“…The discovery of novel early detection biomarkers of disease could offer one of the best approaches to decrease the morbidity and mortality of ovarian and…”
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Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery by Scholler, Nathalie, Gross, Jennifer A, Garvik, Barbara, Wells, Lance, Liu, Yan, Loch, Christian M, Ramirez, Arturo B, McIntosh, Martin W, Lampe, Paul D, Urban, Nicole

“…Strategies to discover circulating protein markers of ovarian cancer are urgently needed. We developed a novel technology that permits us to isolate…”
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Protein Microarrays for the Identification of Praja1 E3 Ubiquitin Ligase Substrates by Loch, Christian M., Eddins, Michael J., Strickler, James E.

“…Although they are the primary determinants of substrate specificity, few E3-substrate pairs have been positively identified, and few E3’s profiled in a…”
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Comparison of fluorine-18 and bromine-76 imaging in positron emission tomography by Ribeiro, M J, Almeida, P, Strul, D, Ferreira, N, Loc'h, C, Brulon, V, Trébossen, R, Mazière, B, Bendriem, B

“…State of the art positron emission tomography (PET) systems allow for scatter and attenuation correction. However, the size of the structure being studied and…”
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Synthesis and pharmacological evaluation of [F]PBR316: a novel PET ligand targeting the translocator protein 18 kDa (TSPO) with low binding sensitivity to human single nucleotide polymorphism rs6971 by Mattner, Filomena, Katsifis, Andrew, Bourdier, Thomas, Loc'h, Christian, Berghofer, Paula, Fookes, Christopher, Hung, Tzong-Tyng, Jackson, Timothy, Henderson, David, Pham, Tien, Lee, Brendan J, Shepherd, Rachael, Greguric, Ivan, Wyatt, Naomi, Le, Thanh, Poon, Jackson, Power, Carl, Fulham, Michael

“…Radiopharmaceuticals that target the translocator protein 18 kDa (TSPO) have been investigated with positron emission tomography (PET) to study…”
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In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat by Dedeurwaerdere, Stefanie, Gregoire, Marie-Claude, Vivash, Lucy, Roselt, Peter, Binns, David, Fookes, Christopher, Greguric, Ivan, Pham, Tien, Loc’h, Christian, Katsifis, Andrew, Hicks, Rodney J., O’Brien, Terence J., Myers, Damian E.

“…Purpose [ 11 C]Flumazenil shows promise as a clinical and research PET radiotracer to image changes in GABA A central benzodiazepine receptor (cBZR), but its…”
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Genome-wide Analysis of ARS (Autonomously Replicating Sequence) Binding Factor 1 (Abf1p)-mediated Transcriptional Regulation in Saccharomyces cerevisiae by Miyake, Tsuyoshi, Reese, Justin, Loch, Christian M, Auble, David T, Li, Rong

“…Autonomously replicating sequence-binding factor-1 (Abf1p) is an essential sequence-specific transcription factor in Saccharomyces cerevisiae that participates…”
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