Search Results - "Lobley, Anna"

Specialized contact sites regulate the fusion of chlamydial inclusion membranes by Linton, Christine, Wesolowski, Jordan, Lobley, Anna, Yamaji, Toshiyuki, Hanada, Kentaro, Paumet, Fabienne

“…The intracellular bacterial pathogen Chlamydia trachomatis replicates within a membrane-bound compartment called the inclusion. Upon infection with several…”
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pGenTHREADER and pDomTHREADER: new methods for improved protein fold recognition and superfamily discrimination by Lobley, Anna, Sadowski, Michael I., Jones, David T.

“…Motivation: Generation of structural models and recognition of homologous relationships for unannotated protein sequences are fundamental problems in…”
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Cell-vision fusion: A Swin transformer-based approach for predicting kinase inhibitor mechanism of action from Cell Painting data by Dee, William, Sequeira, Ines, Lobley, Anna, Slabaugh, Gregory

“…Image-based profiling of the cellular response to drug compounds has proven effective at characterizing the morphological changes resulting from perturbation…”
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Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA by Cingolani, Gino, McCauley, Michael, Lobley, Anna, Bryer, Alexander J., Wesolowski, Jordan, Greco, Deanna L., Lokareddy, Ravi K., Ronzone, Erik, Perilla, Juan R., Paumet, Fabienne

“…Many intracellular bacteria, including Chlamydia , establish a parasitic membrane-bound organelle inside the host cell that is essential for the bacteria’s…”
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The Human Plasma Proteome by Anderson, N. Leigh, Polanski, Malu, Pieper, Rembert, Gatlin, Tina, Tirumalai, Radhakrishna S., Conrads, Thomas P., Veenstra, Timothy D., Adkins, Joshua N., Pounds, Joel G., Fagan, Richard, Lobley, Anna

“…We have merged four different views of the human plasma proteome, based on different methodologies, into a single nonredundant list of 1175 distinct gene…”
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Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling by Coda, Davide M, Gaarenstroom, Tessa, East, Philip, Patel, Harshil, Miller, Daniel S J, Lobley, Anna, Matthews, Nik, Stewart, Aengus, Hill, Caroline S

“…NODAL/Activin signaling orchestrates key processes during embryonic development via SMAD2. How SMAD2 activates programs of gene expression that are modulated…”
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Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data by Edwards, Yvonne J K, Lobley, Anna E, Pentony, Melissa M, Jones, David T

“…Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through…”
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Inferring function using patterns of native disorder in proteins by Lobley, Anna, Swindells, Mark B, Orengo, Christine A, Jones, David T

“…Natively unstructured regions are a common feature of eukaryotic proteomes. Between 30% and 60% of proteins are predicted to contain long stretches of…”
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1182 Bispecific GPRC5D antibodies with potent cell-killing activity against multiple myeloma by Roth, Hayley, Sanchez, Ileine, Tyrell, Breanna, Lobley, Anna, Barnes, Trevor, Cunningham, Alyssa, Nwogu, Nnenna, Doolan, Kyle, Doranz, Benjamin, Rucker, Joseph, Chambers, Ross

“…BackgroundGPRC5D is a G protein-coupled receptor that is expressed on multiple myeloma cells but absent from most healthy tissues except for hair follicles…”
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1183 Development of CTIM-76, a highly specific Claudin 6 bispecific antibody by Rucker, Joseph, Sanchez, Ileine, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nicholas, Shema, Kristin, Guldner, Kyle, Roth, Hayley, Cunningham, Alyssa, Slovik, Kate, Butz, Eric, Roberts, Stanley, Byrnes-Blake, Kelly, Payne, Riley, Calamai, Ed, Chambers, Ross

“…BackgroundCTIM-76 is a bispecific Claudin 6 (CLDN6) T-cell engager antibody in preclinical development for treatment of CLDN6-positive cancers, including…”
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Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer by Gadaleta, Emanuela, Fourgoux, Pauline, Pirró, Stefano, Thorn, Graeme J., Nelan, Rachel, Ironside, Alastair, Rajeeve, Vinothini, Cutillas, Pedro R., Lobley, Anna E., Wang, Jun, Gea, Esteban, Ross-Adams, Helen, Bessant, Conrad, Lemoine, Nicholas R., Jones, Louise J., Chelala, Claude

“…Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving…”
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ZODET: software for the identification, analysis and visualisation of outlier genes in microarray expression data by Roden, Daniel L, Sewell, Gavin W, Lobley, Anna, Levine, Adam P, Smith, Andrew M, Segal, Anthony W

“…Complex human diseases can show significant heterogeneity between patients with the same phenotypic disorder. An outlier detection strategy was developed to…”
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UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene by Williamson, Laura, Saponaro, Marco, Boeing, Stefan, East, Philip, Mitter, Richard, Kantidakis, Theodoros, Kelly, Gavin P., Lobley, Anna, Walker, Jane, Spencer-Dene, Bradley, Howell, Michael, Stewart, Aengus, Svejstrup, Jesper Q.

“…The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown…”
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Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis by Lobley, Anna, Pierron, Valerie, Reynolds, Lindsey, Allen, Liz, Michalovich, David

“…CatSper1 and CatSper2 are two recently identified channel-like proteins, which show sperm specific expression patterns. Through targeted mutagenesis in the…”
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The human plasma proteome: a nonredundant list developed by combination of four separate sources by Anderson, N Leigh, Polanski, Malu, Pieper, Rembert, Gatlin, Tina, Tirumalai, Radhakrishna S, Conrads, Thomas P, Veenstra, Timothy D, Adkins, Joshua N, Pounds, Joel G, Fagan, Richard, Lobley, Anna

“…We have merged four different views of the human plasma proteome, based on different methodologies, into a single nonredundant list of 1175 distinct gene…”
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Abstract 2892: Development of claudin 6 bispecific antibodies for treatment of ovarian cancer by Rucker, Joseph, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nick, Shema, Kristen, Guldner, Kyle, Cunningham, Alyssa, Chambers, Ross, Payne, Riley

“…Abstract There is growing interest in applying antibody modalities including bispecifics, antibody-drug conjugates, and CART to solid tumors. However,…”
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Abstract 2151: Identification of transcript adenosine fingerprint to enrich for A2AR and PD-1 inhibition responders by Alt, Isabella, Sehlke, Robert, Lobley, Anna, Baumgaertler, Claudia, Stulic, Maja, Hackner, Klaus, Dzurillova, Lucia, Petru, Edgar, Hadjari, Laudia, Lafleur, Judith, Singer, Josef, Krall, Nikolaus, Šufliarsky, Jozef, Hefler, Lukas, Füreder, Thorsten, Taubert, Christina, Payne, Andrew, Boudesco, Christophe, Vladimer, Gregory Ian

“…Abstract Background: Precision cancer medicine aims to identify the right drug for the right patient, enriching for patients more likely to respond to a…”
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Abstract 1865: Development of CTIM-76, a highly specific Claudin 6 bispecific antibody for treatment of ovarian cancer by Rucker, Joseph, Sanchez, Ileine, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nicholas, Shema, Kristen, Guldner, Kyle, Roth, Hayley, Cunningham, Alyssa, Slovik, Kate, Payne, Riley, Butz, Eric, Dick, Evan, Calamai, Edward, Chambers, Ross

“…Abstract Solid tumors lead to 580,000 deaths annually in the US, and safe and effective therapeutics for many late-stage solid tumors are lacking. Ovarian…”
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Abstract 4150: Enriching for adenosine antagonist patient responses through deep learning by Alt, Isabella, Shelke, Robert, Lobley, Anna, Baumgaertler, Claudia, Stulic, Maja, Fons, Pierre, Whittaker, Mark, Hackner, Klaus, Dzurillova, Lucia, Petru, Edga, Hadjari, Laudia, Lafleur, Judith, Singer, Josef, Krall, Nikolaus, Hefler, Lukas, Füreder, Thorsten, Taubert, Christina, Boudesco, Christophe, Payne, Andrew, Ian Vladimer, Gregory

“…Abstract Background: Adenosine signaling is a key metabolic pathway regulating tumor immunity. The conversion of inflammatory extracellular ATP into…”
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Abstract 6305: Bispecific claudin 18.2 and GPRC5D antibodies with potent cell-killing activity for cancer therapeutics by Sanchez, Ileine, Roth, Hayley, Screnci, Brad, Tucker, David, Molino, Nick, Barnes, Trevor, Murphy, Paige, Guldner, Kyle, Phillips, Tim, Shema, Kristen, Charpentier, Thomas, Cunningham, Alyssa, Latta, Janae, Tyrell, Breanna, Pitts, Meghan, Navia, Carmen, Azuelos, Charles, Lobley, Anna, Karam, Jawhara, Fiers, Valerie, Reyes, Daniela, Slovik, Kate, Snyder, Alison, Assogba, Marianne, Chang, Kai-Ti, Payne, Riley, Doolan, Kyle, Chambers, Ross, Rucker, Joe, Doranz, Benjamin

“…Abstract Tumor-associated antigens with little or no expression in healthy tissue are attractive targets for anti-tumor modalities including T cell-engaging…”
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