Search Results - "Lobito, Adrian A."

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome by Simon, Anna, Park, Heiyoung, Maddipati, Ravikanth, Lobito, Adrian A, Bulua, Ariel C, Jackson, Adrianna J, Chae, Jae Jin, Ettinger, Rachel, de Koning, Heleen D, Cruz, Anthony C, Kastner, Daniel L, Komarow, Hirsh, Siegel, Richard M

“…TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the pathogenesis of many inflammatory diseases. TNFR-associated periodic…”
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Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS) by Lobito, Adrian A., Kimberley, Fiona C., Muppidi, Jagan R., Komarow, Hirsh, Jackson, Adrianna J., Hull, Keith M., Kastner, Daniel L., Screaton, Gavin R., Siegel, Richard M.

“…Tumor necrosis factor (TNF) receptor–associated periodic syndrome (TRAPS) is an autosomal dominant systemic autoinflammatory disease associated with…”
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Disease causing mutations in the TNF and TNFR superfamilies: Focus on molecular mechanisms driving disease by Lobito, Adrian A, Gabriel, Tanit L, Medema, Jan Paul, Kimberley, Fiona C

“…The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies comprise multidomain proteins with diverse roles in cell activation, proliferation and…”
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Murine Insulin Growth Factor-like (IGFL) and Human IGFL1 Proteins Are Induced in Inflammatory Skin Conditions and Bind to a Novel Tumor Necrosis Factor Receptor Family Member, IGFLR1 by Lobito, Adrian A., Ramani, Sree R., Tom, Irene, Bazan, J. Fernando, Luis, Elizabeth, Fairbrother, Wayne J., Ouyang, Wenjun, Gonzalez, Lino C.

“…Psoriasis is a human skin condition characterized by epidermal hyperproliferation and infiltration of multiple leukocyte populations. In characterizing a novel…”
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Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID) by Garibyan, Lilit, Lobito, Adrian A, Siegel, Richard M, Call, Matthew E, Wucherpfennig, Kai W, Geha, Raif S

“…B cells from patients with common variable immunodeficiency (CVID) who are heterozygous for transmembrane activator and CAML interactor (TACI) mutation C104R,…”
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Recent advances in the molecular pathogenesis of hereditary recurrent fevers by Masters, Seth L, Lobito, Adrian A, Chae, JaeJin, Kastner, Daniel L

“…PURPOSE OF REVIEWTo discuss recent developments in the molecular basis of several hereditary recurrent fever syndromes, specifically the cryopyrin-associated…”
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Falling into TRAPS--receptor misfolding in the TNF receptor 1-associated periodic fever syndrome by Kimberley, Fiona C, Lobito, Adrian A, Siegel, Richard M, Screaton, Gavin R

“…TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients…”
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Ectopic T cell receptor expression causes B cell immunodeficiency in transgenic mice by Lobito, Adrian A., Lopes, Marcela F., Lenardo, Michael J.

“…Mice expressing transgenic T cell receptors (TCR) are used to explore important questions in immunity. However, transgene expression may have unexpected…”
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Determinant Spreading Associated with Demyelination in a Nonhuman Primate Model of Multiple Sclerosis by McFarland, Hugh I, Lobito, Adrian A, Johnson, Michele M, Nyswaner, Jeffrey T, Frank, Joseph A, Palardy, Gregory R, Tresser, Nancy, Genain, Claude P, Mueller, John P, Matis, Louis A, Lenardo, Michael J

“…Definition of the immune process that causes demyelination in multiple sclerosis is essential to determine the feasibility of Ag-directed immunotherapy. Using…”
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Effective Antigen-Specific Immunotherapy in the Marmoset Model of Multiple Sclerosis by McFarland, Hugh I, Lobito, Adrian A, Johnson, Michele M, Palardy, Gregory R, Yee, Christina S. K, Jordan, E. Kay, Frank, Joseph A, Tresser, Nancy, Genain, Claude P, Mueller, John P, Matis, Louis A, Lenardo, Michael J

“…Mature T cells initially respond to Ag by activation and expansion, but high and repeated doses of Ag cause programmed cell death and can suppress T…”
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T cell receptor transgenic mice recognizing the immunodominant epitope of the Torpedo californica acetylcholine receptor by Lobito, Adrian A., Yang, Bingzhi, Lopes, Marcela F., Miagkov, Alexei, Adams, Robert N., Palardy, Gregory R., Johnson, Michele M., McFarland, Hugh I., Recher, Michael, Drachman, Daniel B., Lenardo, Michael J.

“…Myasthenia gravis (MG) is an autoimmune disease caused by T cell‐dependent antibody‐mediated reduction of acetylcholine receptors (AChR) at the neuromuscular…”
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Inhibition of Fas‐mediated apoptosis by the B cell antigen receptor through c‐FLIP by Wang, Jin, Lobito, Adrian A., Shen, Fan, Hornung, Felicita, Winoto, Astar, Lenardo, Michael J.

“…Cross‐linking of the B cell antigen receptor (BCR) induces resistance to Fas (APO‐1 / CD95)‐dependent apoptosis and thereby regulates one mechanism of B cell…”
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Production and Characterization of a T Cell Receptor Transgenic Mouse Recognizing the Immunodominant Epitope of the Torpedo californica Acetylcholine Receptor by MIAGKOV, ALEXEI, LOBITO, ADRIAN A., YANG, BINGZHI, LOPES, MARCELA F., ADAMS, ROBERT N., PALARDY, GREGORY R., JOHNSON, MICHELE M., McFARLAND, HUGH I., LENARDO, MICHAEL J., DRACHMAN, DANIEL B.

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