Search Results - "Lobie, Peter E"

Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis by Wu, Mingming, Zhang, Xiao, Zhang, Weijie, Chiou, Yi Shiou, Qian, Wenchang, Liu, Xiangtian, Zhang, Min, Yan, Hong, Li, Shilan, Li, Tao, Han, Xinghua, Qian, Pengxu, Liu, Suling, Pan, Yueyin, Lobie, Peter E., Zhu, Tao

“…Cancer cells display phenotypic equilibrium between the stem-like and differentiated states during neoplastic homeostasis. The functional and mechanistic…”
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Mitochondria: The metabolic switch of cellular oncogenic transformation by Tan, Yan Qin, Zhang, Xi, Zhang, Shuwei, Zhu, Tao, Garg, Manoj, Lobie, Peter E., Pandey, Vijay

“…Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited organelles with bacterial ancestry that play essential roles in a myriad…”
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MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression by Kong, Xiangjun, Li, Gaopeng, Yuan, Yan, He, Yan, Wu, Xiaoli, Zhang, Weijie, Wu, Zhengsheng, Chen, Tingting, Wu, Wenyong, Lobie, Peter E, Zhu, Tao

“…Focal adhesion kinase (FAK) is an important mediator of extracellular matrix integrin signaling, cell motility, cell proliferation and cell survival. Increased…”
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Bad phosphorylation as a target of inhibition in oncology by Bui, Ngoc-Linh-Chi, Pandey, Vijay, Zhu, Tao, Ma, Lan, Basappa, Lobie, Peter E.

“…Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown…”
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Triple negative breast cancer in Asia: An insider’s view by Wang, Chao, Kar, Shreya, Lai, Xianning, Cai, Wanpei, Arfuso, Frank, Sethi, Gautam, Lobie, Peter E., Goh, Boon C., Lim, Lina H.K., Hartman, Mikael, Chan, Ching W., Lee, Soo C., Tan, Sing H., Kumar, Alan P.

“…•A comprehensive introduction on the characteristics of TNBC and its heterogeneity.•A comprehensive comparison of TNBC prevalence in Western and Asian…”
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c-MYC-regulated miR-23a/24-2/27a Cluster Promotes Mammary Carcinoma Cell Invasion and Hepatic Metastasis by Targeting Sprouty2 by Li, Xiaoni, Liu, Xin, Xu, Weiyi, Zhou, Peng, Gao, Ping, Jiang, Songshan, Lobie, Peter E., Zhu, Tao

“…Emerging evidence indicates that the miR-23a/24-2/27a cluster may possess a causal role in mammary tumorigenesis and function as a novel class of oncogenes…”
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Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration by Cao, Yuanxiong, Tan, Jiayi, Zhao, Haoran, Deng, Ting, Hu, Yunxia, Zeng, Junhong, Li, Jiawei, Cheng, Yifan, Tang, Jiyuan, Hu, Zhiwei, Hu, Keer, Xu, Bing, Wang, Zitian, Wu, Yaojiong, Lobie, Peter E., Ma, Shaohua

“…Transplantation of mesenchymal stem cells (MSCs) holds promise to repair severe traumatic injuries. However, current transplantation practices limit the…”
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Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor by Liu, Ying, Chen, Chunying, Qian, Pengxu, Lu, Xuefei, Sun, Baoyun, Zhang, Xiao, Wang, Liming, Gao, Xingfa, Li, Han, Chen, Zhiyun, Tang, Jinglong, Zhang, Weijie, Dong, Jinquan, Bai, Ru, Lobie, Peter E., Wu, Qingfa, Liu, Suling, Zhang, Huafeng, Zhao, Feng, Wicha, Max S., Zhu, Tao, Zhao, Yuliang

“…The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers for existing therapeutic agents. Here, we provide…”
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Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2 by Tan, Sheng, Ding, Keshuo, Li, Rui, Zhang, Weijie, Li, Gaopeng, Kong, Xiangjun, Qian, Pengxu, Lobie, Peter E, Zhu, Tao

“…Estrogen signaling is pivotal in the progression of estrogen receptor positive breast cancer primarily by the regulation of cell survival and proliferation…”
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Amplification of hsa-miR-191/425 locus promotes breast cancer proliferation and metastasis by targeting DICER1 by Zhang, Xiao, Wu, Mingming, Chong, Qing-Yun, Zhang, Weijie, Qian, Pengxu, Yan, Hong, Qian, Wenchang, Zhang, Min, Lobie, Peter E, Zhu, Tao

“…Abstract The dysregulation of micro RNAs (miRNAs) is a crucial characteristic of human cancers. Herein, we observed frequent amplification of the MIR191/425…”
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EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy by Bao, Yi, Oguz, Gokce, Lee, Wee Chyan, Lee, Puay Leng, Ghosh, Kakaly, Li, Jiayao, Wang, Panpan, Lobie, Peter E., Ehmsen, Sidse, Ditzel, Henrik J., Wong, Andrea, Tan, Ern Yu, Lee, Soo Chin, Yu, Qiang

“…HER2-targeted therapy has yielded a significant clinical benefit in patients with HER2+ breast cancer, yet disease relapse due to intrinsic or acquired…”
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Synthesis, characterization and cytotoxicity studies of 1,2,3-triazoles and 1,2,4-triazolo [1,5-a] pyrimidines in human breast cancer cells by Gilandoust, Maryam, Harsha, Kachigere B., Mohan, Chakrabhavi Dhananjaya, Raquib, Ainiah Rushdiana, Rangappa, Shobith, Pandey, Vijay, Lobie, Peter E., Basappa, Rangappa, Kanchugarakoppal S.

“…[Display omitted] •VEGFR signalling is associated with the progression of various malignancies.•1,2,3-Triazoles and 1,2,4-triazolo-pyrimidines were synthesized…”
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Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer by Zhang, Weijie, Qian, Pengxu, Zhang, Xiao, Zhang, Min, Wang, Hong, Wu, Mingming, Kong, Xiangjun, Tan, Sheng, Ding, Keshuo, Perry, Jo K., Wu, Zhengsheng, Cao, Yuan, Lobie, Peter E., Zhu, Tao

“…Human growth hormone (hGH) plays critical roles in pubertal mammary gland growth, development, and sexual maturation. Accumulated studies have reported that…”
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The GDNF Family: A Role in Cancer? by Fielder, Graeme C., Yang, Teresa Wen-Shan, Razdan, Mahalakshmi, Li, Yan, Lu, Jun, Perry, Jo K., Lobie, Peter E., Liu, Dong-Xu

“…The glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, neurturin, artemin, and persephin plays an important role…”
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miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway by Tan, Sheng, Li, Rui, Ding, Keshuo, Lobie, Peter E., Zhu, Tao

“…► miR-198 directly targets c-MET via its 3′UTR. ► miR-198 expression reduced c-MET expression and HGF induced p44/42 MAPK activation. ► miR-198 expression…”
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XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation by Huang, Xing, Wang, Xiao-nan, Yuan, Xiao-dong, Wu, Wen-yong, Lobie, Peter E., Wu, Zhengsheng

“…X-linked inhibitor of apoptosis protein (XIAP) possesses a critical role in promotion of cell survival and maintenance of cellular homeostasis. In cancer,…”
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Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells by Basappa, Basappa, Chumadathil Pookunoth, Baburajeev, Shinduvalli Kempasiddegowda, Mamatha, Knchugarakoppal Subbegowda, Rangappa, Lobie, Peter E, Pandey, Vijay

“…Herein, the activity of adamantanyl-tethered-biphenyl amines (ATBAs) as oestrogen receptor alpha (ERα) modulating ligands is reported. Using an ERα competitor…”
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GSE1 predicts poor survival outcome in gastric cancer patients by SLC7A5 enhancement of tumor growth and metastasis by Ding, Keshuo, Tan, Sheng, Huang, Xing, Wang, Xiaonan, Li, Xiaocan, Fan, Rong, Zhu, Yong, Lobie, Peter E., Wang, Wenbin, Wu, Zhengsheng

“…Gastric cancer remains a malignancy with poor survival outcome. We herein report that GSE1, a proline-rich protein, possesses a role in the progression of…”
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Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer by Kansara, Samarth, Pandey, Vijay, Lobie, Peter E, Sethi, Gautam, Garg, Manoj, Pandey, Amit Kumar

“…Triple-negative breast cancer (TNBC) is one of the most lethal forms of breast cancer (BC), with a significant disease burden worldwide. Chemoresistance and…”
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Machine Learning for Endometrial Cancer Prediction and Prognostication by Bhardwaj, Vipul, Sharma, Arundhiti, Parambath, Snijesh Valiya, Gul, Ijaz, Zhang, Xi, Lobie, Peter E., Qin, Peiwu, Pandey, Vijay

“…Endometrial cancer (EC) is a prevalent uterine cancer that remains a major contributor to cancer-associated morbidity and mortality. EC diagnosed at advanced…”
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