Search Results - "Lobb, Collin J"

A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons by Lobb, Collin J, Wilson, Charles J, Paladini, Carlos A

“…Dopaminergic neurons are subject to a significant background GABAergic input in vivo. The presence of this GABAergic background might be expected to inhibit…”
Get full text

Accelerating genomic workflows using NVIDIA Parabricks by O'Connell, Kyle A, Yosufzai, Zelaikha B, Campbell, Ross A, Lobb, Collin J, Engelken, Haley T, Gorrell, Laura M, Carlson, Thad B, Catana, Josh J, Mikdadi, Dina, Bonazzi, Vivien R, Klenk, Juergen A

“…As genome sequencing becomes better integrated into scientific research, government policy, and personalized medicine, the primary challenge for researchers is…”
Get full text

Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior by Zweifel, Larry S, Parker, Jones G, Lobb, Collin J, Rainwater, Aundrea, Wall, Valerie Z, Fadok, Jonathan P, Darvas, Martin, Kim, Min J, Mizumori, Sheri J.Y, Paladini, Carlos A, Phillips, Paul E.M, Palmiter, Richard D

“…Midbrain dopamine (DA) neurons fire in 2 characteristic modes, tonic and phasic, which are thought to modulate distinct aspects of behavior. However, the…”
Get full text

High-frequency, short-latency disinhibition bursting of midbrain dopaminergic neurons by Lobb, Collin J, Wilson, Charles J, Paladini, Carlos A

“…During reinforcement and sequence learning, dopaminergic neurons fire bursts of action potentials. Dopaminergic neurons in vivo receive strong background…”
Get full text

Disinhibition bursting of dopaminergic neurons by Lobb, Collin J, Troyer, Todd W, Wilson, Charles J, Paladini, Carlos A

“…Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr)…”
Get full text

Application of a NMDA receptor conductance in rat midbrain dopaminergic neurons using the dynamic clamp technique by Lobb, Collin J, Paladini, Carlos A

“…Neuroscientists study the function of the brain by investigating how neurons in the brain communicate. Many investigators look at changes in the electrical…”
Get full text

The generation of disinhibition bursts of dopaminergic neurons in the basal ganglia by Lobb, Collin J, Paladini, Carlos A, Wilson, Charles J, Troyer, Todd W

“…[...]in vivo we expect SNpc activity to depend on the neuron’s intrinsic pacemaking currents acting in tandem with tonic NMDA and GABAA-mediated synaptic…”
Get full text

Application of a NMDA Receptor Conductance in Rat Midbrain Dopaminergic Neurons Using the Dynamic Clamp Technique by Lobb, Collin J, Paladini, Carlos A

Get full text

Parallel Event-Driven Neural Network Simulations Using the Hodgkin-Huxley Neuron Model by Lobb, Collin J., Chao, Zenas, Fujimoto, Richard M., Potter, Steve M.

“…Neural systems are composed of a large number of highly-connected neurons and are widely simulated within the neurological community. In this paper, we examine…”
Get full text

GABAergic inhibition and disinhibition of midbrain dopaminergic neurons by Lobb, Collin J

“…Midbrain dopaminergic neurons are strongly implicated in Parkinson's disease, drug addiction, and reinforcement learning. Within reinforcement learning, they…”
Get full text