Search Results - "Lobatto, Mark E."

Perspectives and opportunities for nanomedicine in the management of atherosclerosis by Mulder, Willem J. M, Lobatto, Mark E, Fuster, Valentin, Fayad, Zahi A

“…Key Points Nanomedicine — the use of nanotechnology for medical purposes — is a fast-growing field that has had numerous applications in cancer and is now…”
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A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation by Duivenvoorden, Raphaël, Tang, Jun, Cormode, David P., Mieszawska, Aneta J., Izquierdo-Garcia, David, Ozcan, Canturk, Otten, Maarten J., Zaidi, Neeha, Lobatto, Mark E., van Rijs, Sarian M., Priem, Bram, Kuan, Emma L., Martel, Catherine, Hewing, Bernd, Sager, Hendrik, Nahrendorf, Matthias, Randolph, Gwendalyn J., Stroes, Erik S. G., Fuster, Valentin, Fisher, Edward A., Fayad, Zahi A., Mulder, Willem J. M.

“…Inflammation is a key feature of atherosclerosis and a target for therapy. Statins have potent anti-inflammatory properties but these cannot be fully exploited…”
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Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis by Kim, YongTae, Lobatto, Mark E., Kawahara, Tomohiro, Chung, Bomy Lee, Mieszawska, Aneta J., Sanchez-Gaytan, Brenda L., Fay, Francois, Senders, Max L., Calcagno, Claudia, Becraft, Jacob, Saung, May Tun, Gordon, Ronald E., Stroes, Erik S. G., Ma, Mingming, Farokhzad, Omid C., Fayad, Zahi A., Mulder, Willem J. M., Langer, Robert

“…Therapeutic and diagnostic nanomaterials are being intensely studied for several diseases, including cancer and atherosclerosis. However, the exact mechanism…”
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Nonpharmacological Lipoprotein Apheresis Reduces Arterial Inflammation in Familial Hypercholesterolemia by van Wijk, Diederik F., MD, Sjouke, Barbara, MD, Figueroa, Amparo, MD, Emami, Hamed, MD, van der Valk, Fleur M., MD, MacNabb, Megan H., BA, Hemphill, Linda C., MD, Schulte, Dominik M., MD, PhD, Koopman, Marion G., MD, PhD, Lobatto, Mark E., MD, Verberne, Hein J., MD, PhD, Fayad, Zahi A., MD, PhD, Kastelein, John J.P., MD, PhD, Mulder, Willem J.M., PhD, Hovingh, G. Kees, MD, PhD, Tawakol, Ahmed, MD, Stroes, Erik S.G., MD, PhD

“…Abstract Background Patients with familial hypercholesterolemia (FH) are characterized by elevated atherogenic lipoprotein particles, predominantly low-density…”
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Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform by Cormode, David P, Skajaa, Torjus, van Schooneveld, Matti M, Koole, Rolf, Jarzyna, Peter, Lobatto, Mark E, Calcagno, Claudia, Barazza, Alessandra, Gordon, Ronald E, Zanzonico, Pat, Fisher, Edward A, Fayad, Zahi A, Mulder, Willem J. M

“…High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique…”
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Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging by Lobatto, Mark E, Calcagno, Claudia, Millon, Antoine, Senders, Max L, Fay, Francois, Robson, Philip M, Ramachandran, Sarayu, Binderup, Tina, Paridaans, Maarten P.M, Sensarn, Steven, Rogalla, Stephan, Gordon, Ronald E, Cardoso, Luis, Storm, Gert, Metselaar, Josbert M, Contag, Christopher H, Stroes, Erik S. G, Fayad, Zahi A, Mulder, Willem J.M

“…Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and…”
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Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation by Tang, Jun, Lobatto, Mark E, Hassing, Laurien, van der Staay, Susanne, van Rijs, Sarian M, Calcagno, Claudia, Braza, Mounia S, Baxter, Samantha, Fay, Francois, Sanchez-Gaytan, Brenda L, Duivenvoorden, Raphaël, Sager, Hendrik, Astudillo, Yaritzy M, Leong, Wei, Ramachandran, Sarayu, Storm, Gert, Pérez-Medina, Carlos, Reiner, Thomas, Cormode, David P, Strijkers, Gustav J, Stroes, Erik S G, Swirski, Filip K, Nahrendorf, Matthias, Fisher, Edward A, Fayad, Zahi A, Mulder, Willem J M

“…Inflammation drives atherosclerotic plaque progression and rupture, and is a compelling therapeutic target. Consequently, attenuating inflammation by reducing…”
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In Vivo Characterization of a New Abdominal Aortic Aneurysm Mouse Model With Conventional and Molecular Magnetic Resonance Imaging by Klink, Ahmed, Heynens, Joeri, Herranz, Beatriz, PhD, Lobatto, Mark E., MD, Arias, Teresa, PhD, Sanders, Honorius M.H.F., PhD, Strijkers, Gustav J., PhD, Merkx, Maarten, PhD, Nicolay, Klaas, PhD, Fuster, Valentin, MD, PhD, Tedgui, Alain, PhD, Mallat, Ziad, MD, PhD, Mulder, Willem J.M., PhD, Fayad, Zahi A., PhD

“…Objectives The goal of this study was to use noninvasive conventional and molecular magnetic resonance imaging (MRI) to detect and characterize abdominal…”
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Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques by Calcagno, Claudia, Lobatto, Mark E., Dyvorne, Hadrien, Robson, Philip M., Millon, Antoine, Senders, Max L., Lairez, Olivier, Ramachandran, Sarayu, Coolen, Bram F., Black, Alexandra, Mulder, Willem J. M., Fayad, Zahi A.

“…Atherosclerotic plaques that cause stroke and myocardial infarction are characterized by increased microvascular permeability and inflammation. Dynamic…”
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Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall by Lobatto, Mark E, Binderup, Tina, Robson, Philip M, Giesen, Luuk F. P, Calcagno, Claudia, Witjes, Julia, Fay, Francois, Baxter, Samantha, Wessel, Chang Ho, Eldib, Mootaz, Bini, Jason, Carlin, Sean D, Stroes, Erik S. G, Storm, Gert, Kjaer, Andreas, Lewis, Jason S, Reiner, Thomas, Fayad, Zahi A, Mulder, Willem J. M, Pérez-Medina, Carlos

“…Nanotherapy has recently emerged as an experimental treatment option for atherosclerosis. To fulfill its promise, robust noninvasive imaging approaches for…”
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Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy by Lobatto, Mark E., MD, Calcagno, Claudia, MD, PhD, Otten, Maarten J., MD, Millon, Antoine, MD, PhD, Ramachandran, Sarayu, MS, Paridaans, Maarten P.M., MD, van der Valk, Fleur M., MD, Storm, Gert, PhD, Stroes, Erik S.G., MD PhD, Fayad, Zahi A., PhD, Mulder, Willem J.M., PhD, Metselaar, Josbert M., PhD

“…Abstract The present study describes the development of a good manufacturing practice (GMP)-grade liposomal nanotherapy containing prednisolone phosphate for…”
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Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis by Senders, Max L., Hernot, Sophie, Carlucci, Giuseppe, van de Voort, Jan C., Fay, Francois, Calcagno, Claudia, Tang, Jun, Alaarg, Amr, Zhao, Yiming, Ishino, Seigo, Palmisano, Anna, Boeykens, Gilles, Meerwaldt, Anu E., Sanchez-Gaytan, Brenda L., Baxter, Samantha, Zendman, Laura, Lobatto, Mark E., Karakatsanis, Nicolas A., Robson, Philip M., Broisat, Alexis, Raes, Geert, Lewis, Jason S., Tsimikas, Sotirios, Reiner, Thomas, Fayad, Zahi A., Devoogdt, Nick, Mulder, Willem J.M., Pérez-Medina, Carlos

“…This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic…”
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HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages by Sanchez-Gaytan, Brenda L, Fay, Francois, Lobatto, Mark E, Tang, Jun, Ouimet, Mireille, Kim, YongTae, van der Staay, Susanne E. M, van Rijs, Sarian M, Priem, Bram, Zhang, Liangfang, Fisher, Edward A, Moore, Kathryn J, Langer, Robert, Fayad, Zahi A, Mulder, Willem J. M

“…High-density lipoprotein (HDL) is a natural nanoparticle that exhibits an intrinsic affinity for atherosclerotic plaque macrophages. Its natural targeting…”
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Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species by Binderup, Tina, Duivenvoorden, Raphaël, Fay, Francois, van Leent, Mandy M T, Malkus, Joost, Baxter, Samantha, Ishino, Seigo, Zhao, Yiming, Sanchez-Gaytan, Brenda, Teunissen, Abraham J P, Frederico, Yohana C A, Tang, Jun, Carlucci, Giuseppe, Lyashchenko, Serge, Calcagno, Claudia, Karakatsanis, Nicolas, Soultanidis, Georgios, Senders, Max L, Robson, Philip M, Mani, Venkatesh, Ramachandran, Sarayu, Lobatto, Mark E, Hutten, Barbara A, Granada, Juan F, Reiner, Thomas, Swirski, Filip K, Nahrendorf, Matthias, Kjaer, Andreas, Fisher, Edward A, Fayad, Zahi A, Pérez-Medina, Carlos, Mulder, Willem J M

“…Nanomedicine research produces hundreds of studies every year, yet very few formulations have been approved for clinical use. This is due in part to a reliance…”
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PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis by Senders, Max L., Que, Xuchu, Cho, Young Seok, Yeang, Calvin, Groenen, Hannah, Fay, Francois, Calcagno, Claudia, Meerwaldt, Anu E., Green, Simone, Miu, Phuong, Lobatto, Mark E., Reiner, Thomas, Fayad, Zahi A., Witztum, Joseph L., Mulder, Willem J.M., Pérez-Medina, Carlos, Tsimikas, Sotirios

“…Oxidation-specific epitopes (OSEs) are proinflammatory, and elevated levels in plasma predict cardiovascular events. The purpose of this study was to develop…”
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Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration by van der Valk, Fleur M., M.D, van Wijk, Diederik F, Lobatto, Mark E, Verberne, Hein J, Storm, Gert, Willems, Martine C.M, Legemate, Dink A, Nederveen, Aart J, Calcagno, Claudia, Mani, Venkatesh, Ramachandran, Sarayu, Paridaans, Maarten P.M, Otten, Maarten J, Dallinga-Thie, Geesje M, Fayad, Zahi A, Nieuwdorp, Max, Schulte, Dominik M, Metselaar, Josbert M, Mulder, Willem J.M, Stroes, Erik S., M.D., Ph.D

“…Abstract Drug delivery to atherosclerotic plaques via liposomal nanoparticles may improve therapeutic agents’ risk–benefit ratios. Our paper details the first…”
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Yield of Screening for COVID-19 in Asymptomatic Patients Before Elective or Emergency Surgery Using Chest CT and RT-PCR (SCOUT): Multicenter Study by Puylaert, Carl A. J., Scheijmans, Jochem C. G., Borgstein, Alexander B. J., Andeweg, Caroline S., Bartels-Rutten, Annemarieke, Beets, Geerard L., van Berge Henegouwen, Mark I., Braak, Sicco J., Couvreur, Roy, Daams, Freek, van Es, Hendrik W., Franken, Lotte C., Grotenhuis, Brechtje A., Hendriks, Eduard R., de Hingh, Ignace H. J. T., Hoeijmakers, Fieke, ten Holder, Joris T., Huisman, Peter M., Kazemier, Geert, van Kesteren, Floortje, van Kesteren, Jurre, Keywani, Kammy, Kuiper, Sara Z., Lange, Maurits D. J., Lobatto, Mark E., du Mée, Arthur W. F., Poeze, Martijn, van Praag, Elise M., van Rossen, Jorit, van Santvoort, Hjalmar C., Sedee, Wouter J. A., Seelen, Leonard W. F., Sharabiany, Sarah, Sosef, Nico L., Quanjel, Marian J. R., Veltman, Jeroen, Verhagen, Tim, van de Vlasakker, Vincent C. J., Weeder, Pepijn D., van Werven, Jochem R., Wesdorp, Nina J., van Dieren, Susan, Han, Alvin X., Russell, Colin A., de Jong, Menno D., Bossuyt, Patrick M. M., Quarles van Ufford, Jet M. E., Prokop, Mathias W., Gisbertz, Suzanne S., Prins, Jan M., Besselink, Marc G., Boermeester, Marja A., Gietema, Hester A., Stoker, Jaap

“…OBJECTIVE:To determine the yield of preoperative screening for COVID-19 with chest CT and RT-PCR in patients without COVID-19 symptoms. SUMMARY OF BACKGROUND…”
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In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models by Pérez-Medina, Carlos, PhD, Binderup, Tina, PhD, Lobatto, Mark E., MD, PhD, Tang, Jun, PhD, Calcagno, Claudia, MD, PhD, Giesen, Luuk, BSc, Wessel, Chang Ho, MD, Witjes, Julia, MD, Ishino, Seigo, PhD, Baxter, Samantha, MHS, Zhao, Yiming, PhD, Ramachandran, Sarayu, PhD, Eldib, Mootaz, MSc, Sánchez-Gaytán, Brenda L., PhD, Robson, Philip M., PhD, Bini, Jason, PhD, Granada, Juan F., MD, Fish, Kenneth M., PhD, Stroes, Erik S.G., MD, PhD, Duivenvoorden, Raphaël, MD, PhD, Tsimikas, Sotirios, MD, Lewis, Jason S., PhD, Reiner, Thomas, PhD, Fuster, Valentín, MD, PhD, Kjær, Andreas, MD, PhD, Fisher, Edward A., MD, PhD, Fayad, Zahi A., PhD, Mulder, Willem J.M., PhD

“…Abstract Objectives The goal of this study was to develop and validate a noninvasive imaging tool to visualize the in vivo behavior of high-density lipoprotein…”
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Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis by Lobatto, Mark E, Fayad, Zahi A, Silvera, Stephane, Vucic, Esad, Calcagno, Claudia, Mani, Venkatesh, Dickson, Stephen D, Nicolay, Klaas, Banciu, Manuela, Schiffelers, Raymond M, Metselaar, Josbert M, van Bloois, Louis, Wu, Hai-Shan, Fallon, John T, Rudd, James H, Fuster, Valentin, Fisher, Edward A, Storm, Gert, Mulder, Willem J. M

“…Atherosclerosis is an inflammatory disease causing great morbidity and mortality in the Western world. To increase the anti-inflammatory action and decrease…”
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A Late Complication in a Surgically Corrected ALCAPA Patient by Visser, Pascal C., Keijzers, Mitran, Delewi, Ronak, Lobatto, Mark E., Bot, Pieter T.

“…Late complications in surgically corrected ALCAPA patients are rare. We describe an interesting case of a patient with a thrombosed giant right coronary artery…”
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