Search Results - "Lobatón, Carmen D."

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice by Villa-Pérez, Pablo, Merino, Beatriz, Fernández-Díaz, Cristina M., Cidad, Pilar, Lobatón, Carmen D., Moreno, Alfredo, Muturi, Harrison T., Ghadieh, Hilda E., Najjar, Sonia M., Leissring, Malcolm A., Cózar-Castellano, Irene, Perdomo, Germán

“…The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This…”
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Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice by Merino, Beatriz, Fernández-Díaz, Cristina M., Parrado-Fernández, Cristina, González-Casimiro, Carlos M., Postigo-Casado, Tamara, Lobatón, Carmen D., Leissring, Malcolm A., Cózar-Castellano, Irene, Perdomo, Germán

“…The insulin-degrading enzyme (IDE) is a metalloendopeptidase with a high affinity for insulin. Human genetic polymorphisms in Ide have been linked to increased…”
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Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity by Fernández-Díaz, Cristina M, Merino, Beatriz, López-Acosta, José F, Cidad, Pilar, de la Fuente, Miguel A, Lobatón, Carmen D, Moreno, Alfredo, Leissring, Malcolm A, Perdomo, Germán, Cózar-Castellano, Irene

“…Inhibition of insulin-degrading enzyme (IDE) has been proposed as a possible therapeutic target for type 2 diabetes treatment. However, many aspects of IDE's…”
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Monitoring mitochondrial [Ca2+ ] dynamics with rhod-2, ratiometric pericam and aequorin by Fonteriz, Rosalba I, de la Fuente, Sergio, Moreno, Alfredo, Lobatón, Carmen D, Montero, Mayte, Alvarez, Javier

“…Abstract The dynamics of mitochondrial [Ca2+ ] ([Ca2+ ]M ) plays a key role in a variety of cellular processes. The most important methods available to monitor…”
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Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment by Fernández-Díaz, Cristina M, Escobar-Curbelo, Luis, López-Acosta, J F, Lobatón, Carmen D, Moreno, Alfredo, Sanz-Ortega, Julián, Perdomo, Germán, Cózar-Castellano, Irene

“…Insulin Degrading Enzyme (IDE) is an endopeptidase that degrades insulin and glucagon. Ide gene has been associated with type-2 diabetes mellitus (DM2)…”
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Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids by Montero, Mayte, Lobatón, Carmen D, Hernández-Sanmiguel, Esther, Santodomingo, Jaime, Vay, Laura, Moreno, Alfredo, Alvarez, Javier

“…During cell activation, mitochondria play an important role in Ca2+ homoeostasis due to the presence of a fast and specific Ca2+ channel in its inner membrane,…”
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Germline Genetic Findings Which May Impact Therapeutic Decisions in Families with a Presumed Predisposition for Hereditary Breast and Ovarian Cancer by Velázquez, Carolina, K., De Leeneer, Esteban-Cardeñosa, Eva M., Avila Cobos, Francisco, Lastra, Enrique, Abella, Luis E., de la Cruz, Virginia, Lobatón, Carmen D., Claes, Kathleen B., Durán, Mercedes, Infante, Mar

“…In this study, we aim to gain insight in the germline mutation spectrum of ATM, BARD1, BRIP1, ERCC4, PALB2, RAD51C and RAD51D in breast and ovarian cancer…”
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Leptolide Improves Insulin Resistance in Diet-Induced Obese Mice by Villa-Pérez, Pablo, Cueto, Mercedes, Díaz-Marrero, Ana R, Lobatón, Carmen D, Moreno, Alfredo, Perdomo, Germán, Cózar-Castellano, Irene

“…Type 2 diabetes (T2DM) is a complex disease linked to pancreatic beta-cell failure and insulin resistance. Current antidiabetic treatment regimens for T2DM…”
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Unraveling the molecular effect of a rare missense mutation in BRIP1 associated with inherited breast cancer by Velázquez, Carolina, Esteban‐Cardeñosa, Eva M., Lastra, Enrique, Abella, Luis E., de la Cruz, Virginia, Lobatón, Carmen D., Durán, Mercedes, Infante, Mar

“…BRIP1 is a component of the Fanconi Anemia/BRCA pathway responsible for DNA reparation via helicase activity. Some heterozygous variants in BRIP1 could…”
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A PALB2 truncating mutation: Implication in cancer prevention and therapy of Hereditary Breast and Ovarian Cancer by Velázquez, Carolina, Esteban-Cardeñosa, Eva M., Lastra, Enrique, Abella, Luis E., de la Cruz, Virginia, Lobatón, Carmen D., Durán, Mercedes, Infante, Mar

“…Explaining genetic predisposition in Hereditary Breast and Ovarian Cancer (HBOC) families without BRCA mutations is crucial. Germline PALB2 inactivating…”
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Calcium dynamics in bovine adrenal medulla chromaffin cell secretory granules by SantoDomingo, Jaime, Vay, Laura, Camacho, Marcial, Hernández-SanMiguel, Esther, Fonteriz, Rosalba I., Lobatón, Carmen D., Montero, Mayte, Moreno, Alfredo, Alvarez, Javier

“…The secretory granules constitute one of the less well‐known compartments in terms of Ca2+ dynamics. They contain large amounts of total Ca2+, but the free…”
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Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation by Vay, Laura, Hernández-SanMiguel, Esther, Santo-Domingo, Jaime, Lobatón, Carmen D, Moreno, Alfredo, Montero, Mayte, Alvarez, Javier

“…The recent availability of activators of the mitochondrial Ca 2+ uniporter allows direct testing of the influence of mitochondrial Ca 2+ uptake on the overall…”
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A confocal study on the visualization of chromaffin cell secretory vesicles with fluorescent targeted probes and acidic dyes by Moreno, Alfredo, SantoDomingo, Jaime, Fonteriz, Rosalba I., Lobatón, Carmen D., Montero, Mayte, Alvarez, Javier

“…Secretory vesicles have low pH and have been classically identified as those labelled by a series of acidic fluorescent dyes such as acridine orange or neutral…”
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The mitochondrial Na+/Ca2+ exchanger plays a key role in the control of cytosolic Ca2+ oscillations by Hernández-SanMiguel, Esther, Vay, Laura, Santo-Domingo, Jaime, Lobatón, Carmen D, Moreno, Alfredo, Montero, Mayte, Alvarez, Javier

“…There is increasing evidence that mitochondria play an important role in the control of cytosolic Ca2+ signaling. We show here that the main mitochondrial…”
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The dynamics of mitochondrial Ca2+ fluxes by de la Fuente, Sergio, Montenegro, Pablo, Fonteriz, Rosalba I, Moreno, Alfredo, Lobatón, Carmen D, Montero, Mayte, Alvarez, Javier

“…We have investigated the kinetics of mitochondrial Ca(2+) influx and efflux and their dependence on cytosolic [Ca(2+)] and [Na(+)] using low-Ca(2+)-affinity…”
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A novel regulatory mechanism of the mitochondrial Ca2+ uniporter revealed by the p38 mitogen‐activated protein kinase inhibitor sb202190 by Montero, Mayte, Lobatón, Carmen D., Moreno, Alfredo, Alvarez, Javier

“…ABSTRACT It is widely acknowledged that mitochondrial Ca2+ uptake modulates the cytosolic [Ca2+] ([Ca2+]c) acting as a transient Ca2+ buffer. In addition,…”
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Mitochondrial free [Ca2+ ] levels and the permeability transition by Vay, Laura, Hernández-SanMiguel, Esther, Lobatón, Carmen D, Moreno, Alfredo, Montero, Mayte, Alvarez, Javier

“…Abstract Mitochondrial Ca2+ activates many processes, from mitochondrial metabolism to opening of the permeability transition pore (PTP) and apoptosis…”
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Ca2+ Dynamics in the Secretory Vesicles of Neurosecretory PC12 and INS1 Cells by SantoDomingo, Jaime, Fonteriz, Rosalba I., Lobatón, Carmen D., Montero, Mayte, Moreno, Alfredo, Alvarez, Javier

“…We have investigated the dynamics of the free [Ca 2+ ] inside the secretory granules of neurosecretory PC12 and INS1 cells using a low-Ca 2+ -affinity aequorin…”
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Modulation of Ca(2+) release and Ca(2+) oscillations in HeLa cells and fibroblasts by mitochondrial Ca(2+) uniporter stimulation by Vay, Laura, Hernández-Sanmiguel, Esther, Santo-Domingo, Jaime, Lobatón, Carmen D, Moreno, Alfredo, Montero, Mayte, Alvarez, Javier

“…The recent availability of activators of the mitochondrial Ca(2+) uniporter allows direct testing of the influence of mitochondrial Ca(2+) uptake on the…”
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Modulation of mitochondrial Ca(2+) uptake by estrogen receptor agonists and antagonists by Lobatón, Carmen D, Vay, Laura, Hernández-Sanmiguel, Esther, Santodomingo, Jaime, Moreno, Alfredo, Montero, Mayte, Alvarez, Javier

“…Ca(2+) uptake by mitochondria is a key element in the control of cellular Ca(2+) homeostasis and Ca(2+)-dependent phenomena. It has been known for many years…”
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