Search Results - "Lobanova, Ekaterina"

Methods for In Vivo Characterization of Proteostasis in the Mouse Retina by Wang, Yixiao, Lobanova, Ekaterina S

“…An increasing number of studies connect inherited and age-related retinal degenerations with changes in the regulation of proteostasis. Here, we describe…”
Get more information

Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa by Wang, Yixiao, Punzo, Claudio, Ash, John D, Lobanova, Ekaterina S

“…SignificanceStudies in multiple experimental systems have demonstrated that an increase in proteolytic capacity of post-mitotic cells improves cellular…”
Get full text

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4 by Yeboah, Gyening Kofi, Lobanova, Ekaterina S., Brush, Richard S., Agbaga, Martin-Paul

“…Lipids play essential roles in maintaining cell structure and function by modulating membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4)…”
Get full text

Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration by Lobanova, Ekaterina S., Finkelstein, Stella, Li, Jing, Travis, Amanda M., Hao, Ying, Klingeborn, Mikael, Skiba, Nikolai P., Deshaies, Raymond J., Arshavsky, Vadim Y.

“…Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most…”
Get full text

Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration by Lobanova, Ekaterina S., Finkelstein, Stella, Skiba, Nikolai P., Arshavsky, Vadim Y.

“…Inherited retinal degenerations, caused by mutations in over 100 individual genes, affect approximately 2 million people worldwide. Many of the underlying…”
Get full text

The concept of creativity in the problem field of modern social philosophy by Lobanova, Ekaterina S.

“…This paper speaks of the growing interest in the category of creativity among the scientific community of interdisciplinary discourse, and the place of…”
Get full text

Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction by Lobanova, Ekaterina S, Schuhmann, Kai, Finkelstein, Stella, Lewis, Tylor R, Cady, Martha A, Hao, Ying, Keuthan, Casey, Ash, John D, Burns, Marie E, Shevchenko, Andrej, Arshavsky, Vadim Y

“…Retinal photoreceptor cells contain the highest concentration of docosahexaenoic acid (DHA) in our bodies, and it has been long assumed that this is critical…”
Get full text

Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration by Pearring, Jillian N, San Agustin, Jovenal T, Lobanova, Ekaterina S, Gabriel, Christopher J, Lieu, Eric C, Monis, William J, Stuck, Michael W, Strittmatter, Lara, Jaber, Samer M, Arshavsky, Vadim Y, Pazour, Gregory J

“…Arf4 is proposed to be a critical regulator of membrane protein trafficking in early secretory pathway. More recently, Arf4 was also implicated in regulating…”
Get full text

Systemic Delivery of Genes to Retina Using Adeno-Associated Viruses by Simpson, Chiab P, Bolch, Susan N, Zhu, Ping, Weidert, Frances, Dinculescu, Astra, Lobanova, Ekaterina S

“…Mutations in more than 80 genes lead to photoreceptor degeneration. Although subretinal delivery of genes to photoreceptor neurons using AAV vectors has proven…”
Get more information

Clarin‐1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome by Xu, Lei, Bolch, Susan N, Santiago, Clayton P, Dyka, Frank M, Akil, Omar, Lobanova, Ekaterina S, Wang, Yuchen, Martemyanov, Kirill A, Hauswirth, William W, Smith, W Clay, Handa, James T, Blackshaw, Seth, Ash, John D, Dinculescu, Astra

“…Usher syndrome type 3 (USH3) is an autosomal recessively inherited disorder caused by mutations in the gene clarin‐1 (CLRN1), leading to combined progressive…”
Get full text

C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis by Sharif, Ali S, Yu, Dongmei, Loertscher, Stuart, Austin, Richard, Nguyen, Kevin, Mathur, Pranav D, Clark, Anna M, Zou, Junhuang, Lobanova, Ekaterina S, Arshavsky, Vadim Y, Yang, Jun

“…is a causative gene for three different clinical forms of incurable retinal degeneration. However, the completely unknown function of limits our understanding…”
Get full text

Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness by Wang, Yixiao, Snell, Aaron, Dyka, Frank M, Colvin, Elizabeth R, Ildefonso, Cristhian, Ash, John D, Lobanova, Ekaterina S

“…Proteasomes are the central proteolytic machines that are critical for breaking down most of the damaged and abnormal proteins in human cells. Although…”
Get full text

Acyl-CoA synthetase 6 controls rod photoreceptor function and survival by shaping the phospholipid composition of retinal membranes by Wang, Yixiao, Becker, Silke, Finkelstein, Stella, Dyka, Frank M., Liu, Haitao, Eminhizer, Mark, Hao, Ying, Brush, Richard S., Spencer, William J., Arshavsky, Vadim Y., Ash, John D., Du, Jianhai, Agbaga, Martin-Paul, Vinberg, Frans, Ellis, Jessica M., Lobanova, Ekaterina S.

“…The retina is light-sensitive neuronal tissue in the back of the eye. The phospholipid composition of the retina is unique and highly enriched in…”
Get full text

Phosphoinositide Profile of the Mouse Retina by Finkelstein, Stella, Gospe, 3rd, Sidney M, Schuhmann, Kai, Shevchenko, Andrej, Arshavsky, Vadim Y, Lobanova, Ekaterina S

“…Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported…”
Get full text

Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity by Dexter, Paige M, Lobanova, Ekaterina S, Finkelstein, Stella, Arshavsky, Vadim Y

“…Inherited retinal degenerations originate from mutations in >300 genes, many of which cause the production of misfolded mutant photoreceptor proteins that are…”
Get full text

Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light by Lobanova, Ekaterina S, Herrmann, Rolf, Finkelstein, Stella, Reidel, Boris, Skiba, Nikolai P, Deng, Wen-Tao, Jo, Rebecca, Weiss, Ellen R, Hauswirth, William W, Arshavsky, Vadim Y

“…The remarkable ability of our vision to function under ever-changing conditions of ambient illumination is mediated by multiple molecular mechanisms regulating…”
Get full text

Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa by Shibeko, Alexey M, Lobanova, Ekaterina S, Panteleev, Mikhail A, Ataullakhanov, Fazoil I

“…Blood coagulation is a complex network of biochemical reactions, which is peculiar in that it is time- and space-dependent, and has to function in the presence…”
Get full text

Retinal homeostasis and metformin-induced protection are not affected by retina-specific Pparδ knockout by Xu, Lei, Brown, Emily E., Santiago, Clayton P., Keuthan, Casey J., Lobanova, Ekaterina, Ash, John D.

“…Peroxisome proliferator-activated receptors (PPARs) are a family of three nuclear hormone receptors (PPARα, PPARδ, and PPARγ) that are known to regulate…”
Get full text

Transducin translocation in rods is triggered by saturation of the GTPase-activating complex by Lobanova, Ekaterina S, Finkelstein, Stella, Song, Hongman, Tsang, Stephen H, Chen, Ching-Kang, Sokolov, Maxim, Skiba, Nikolai P, Arshavsky, Vadim Y

“…Light causes massive translocation of G-protein transducin from the light-sensitive outer segment compartment of the rod photoreceptor cell. Remarkably,…”
Get full text

Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability by Lobanova, Ekaterina S, Finkelstein, Stella, Herrmann, Rolf, Chen, Yen-Ming, Kessler, Christopher, Michaud, Norman A, Trieu, Lynn H, Strissel, Katherine J, Burns, Marie E, Arshavsky, Vadim Y

“…Transducin is a prototypic heterotrimeric G-protein mediating visual signaling in vertebrate photoreceptor cells. Despite its central role in…”
Get full text