Search Results - "Lobanenkov, V. V."

CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention by Pugacheva, Elena M., Kubo, Naoki, Loukinov, Dmitri, Tajmul, Md, Kang, Sungyun, Kovalchuk, Alexander L., Strunnikov, Alexander V., Zentner, Gabriel E., Ren, Bing, Lobanenkov, Victor V.

“…The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the…”
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A map of the cis-regulatory sequences in the mouse genome by Shen, Yin, Yue, Feng, McCleary, David F., Ye, Zhen, Edsall, Lee, Kuan, Samantha, Wagner, Ulrich, Dixon, Jesse, Lee, Leonard, Lobanenkov, Victor V., Ren, Bing

“…A genomic map of nearly 300,000 potential cis -regulatory sequences determined from diverse mouse tissues and cell types reveals active promoters, enhancers…”
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Chromatin architecture reorganization during stem cell differentiation by Dixon, Jesse R., Jung, Inkyung, Selvaraj, Siddarth, Shen, Yin, Antosiewicz-Bourget, Jessica E., Lee, Ah Young, Ye, Zhen, Kim, Audrey, Rajagopal, Nisha, Xie, Wei, Diao, Yarui, Liang, Jing, Zhao, Huimin, Lobanenkov, Victor V., Ecker, Joseph R., Thomson, James A., Ren, Bing

“…Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the…”
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Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome by Kim, Tae Hoon, Abdullaev, Ziedulla K., Smith, Andrew D., Ching, Keith A., Loukinov, Dmitri I., Green, Roland D., Zhang, Michael Q., Lobanenkov, Victor V., Ren, Bing

“…Insulator elements affect gene expression by preventing the spread of heterochromatin and restricting transcriptional enhancers from activation of unrelated…”
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Histone modifications at human enhancers reflect global cell-type-specific gene expression by Ren, Bing, Heintzman, Nathaniel D, Hon, Gary C, Hawkins, R. David, Kheradpour, Pouya, Stark, Alexander, Harp, Lindsey F, Ye, Zhen, Lee, Leonard K, Stuart, Rhona K, Ching, Christina W, Ching, Keith A, Antosiewicz-Bourget, Jessica E, Liu, Hui, Zhang, Xinmin, Green, Roland D, Lobanenkov, Victor V, Stewart, Ron, Thomson, James A, Crawford, Gregory E, Kellis, Manolis

“…The human body is composed of diverse cell types with distinct functions. Although it is known that lineage specification depends on cell-specific gene…”
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CTCF Haploinsufficiency Destabilizes DNA Methylation and Predisposes to Cancer by Kemp, Christopher J., Moore, James M., Moser, Russell, Bernard, Brady, Teater, Matt, Smith, Leslie E., Rabaia, Natalia A., Gurley, Kay E., Guinney, Justin, Busch, Stephanie E., Shaknovich, Rita, Lobanenkov, Victor V., Liggitt, Denny, Shmulevich, Ilya, Melnick, Ari, Filippova, Galina N.

“…Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are…”
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BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites by Pugacheva, Elena M, Bhatt, Dharmendra Nath, Rivero-Hinojosa, Samuel, Tajmul, Md, Fedida, Liron, Price, Emma, Ji, Yon, Loukinov, Dmitri, Strunnikov, Alexander V, Ren, Bing, Lobanenkov, Victor V

“…Pervasive usage of alternative promoters leads to the deregulation of gene expression in carcinogenesis and may drive the emergence of new genes in…”
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The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis by Rivero-Hinojosa, Samuel, Pugacheva, Elena M., Kang, Sungyun, Méndez-Catalá, Claudia Fabiola, Kovalchuk, Alexander L., Strunnikov, Alexander V., Loukinov, Dmitri, Lee, Jeannie T., Lobanenkov, Victor V.

“…CTCF is a key organizer of the 3D genome. Its specialized paralog, BORIS, heterodimerizes with CTCF but is expressed only in male germ cells and in cancer…”
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Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos by Moore, James M, Rabaia, Natalia A, Smith, Leslie E, Fagerlie, Sara, Gurley, Kay, Loukinov, Dmitry, Disteche, Christine M, Collins, Steven J, Kemp, Christopher J, Lobanenkov, Victor V, Filippova, Galina N

“…CTCF is a highly conserved, multifunctional zinc finger protein involved in critical aspects of gene regulation including transcription regulation, chromatin…”
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Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene by Renaud, S, Loukinov, D, Abdullaev, Z, Guilleret, I, Bosman, F.T, Lobanenkov, V, Benhattar, J

“…Expression of hTERT is the major limiting factor for telomerase activity. We previously showed that methylation of the hTERT promoter is necessary for its…”
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The novel BORIS+CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer by Klenova, Elena M, Morse, Herbert C, Ohlsson, Rolf, Lobanenkov, Victor V

“…CTCF is a ubiquitous 11 zinc finger (ZF) protein with highly versatile functions: in addition to transcriptional silencing or activating in a context-dependent…”
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An updated catalog of CTCF variants associated with neurodevelopmental disorder phenotypes by Price, Emma, Fedida, Liron M, Pugacheva, Elena M, Ji, Yon J, Loukinov, Dmitri, Lobanenkov, Victor V

“…-related disorder (CRD) is a neurodevelopmental disorder (NDD) caused by monoallelic pathogenic variants in . The first variants in CRD cases were documented…”
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CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer by Bailey, Charles G, Metierre, Cynthia, Feng, Yue, Baidya, Kinsha, Filippova, Galina N, Loukinov, Dmitri I, Lobanenkov, Victor V, Semaan, Crystal, Rasko, John Ej

“…CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. Cancer…”
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An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes by Filippova, Galina N., Fagerlie, Sara, Klenova, Elena M., Myers, Cena, Dehner, Yvonne, Goodwin, Graham, Neiman, Paul E., Collins, Steve J., Lobanenkov, Victor V.

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CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus by Lobanenkov, Victor V, Tapscott, Stephen J, Filippova, Galina N, Thienes, Cortlandt P, Penn, Bennett H, Cho, Diane H, Hu, Ying Jia, Moore, James M, Klesert, Todd R

“…An expansion of a CTG repeat at the DM1 locus causes myotonic dystrophy (DM) by altering the expression of the two adjacent genes, DMPK and SIX5, and through a…”
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Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes by VATOLIN, Sergei, ABDULLAEV, Ziedulla, RISINGER, John I, BARRETT, J. Carl, LOBANENKOV, Victor V, PACK, Svetlana D, FLANAGAN, Patrick T, CUSTER, Mary, LOUKINOV, Dmitri I, PUGACHEVA, Elena, HONG, Julie A, MORSE, Herbert III, SCHRUMP, David S

“…Brother of the Regulator of Imprinted Sites (BORIS) is a mammalian CTCF paralog with the same central 11Zn fingers (11ZF) that mediate specific interactions…”
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Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency by Hawkins, R David, Hon, Gary C, Yang, Chuhu, Antosiewicz-Bourget, Jessica E, Lee, Leonard K, Ngo, Que-Minh, Klugman, Sarit, Ching, Keith A, Edsall, Lee E, Ye, Zhen, Kuan, Samantha, Yu, Pengzhi, Liu, Hui, Zhang, Xinmin, Green, Roland D, Lobanenkov, Victor V, Stewart, Ron, Thomson, James A, Ren, Bing

“…Pluripotency, the ability of a cell to differentiate and give rise to all embryonic lineages, defines a small number of mammalian cell types such as embryonic…”
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BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells by Renaud, Stéphanie, Loukinov, Dmitri, Alberti, Loredana, Vostrov, Alexander, Kwon, Yoo-Wook, Bosman, Fred T, Lobanenkov, Victor, Benhattar, Jean

“…Telomerase activity, not detectable in somatic cells but frequently activated during carcinogenesis, confers immortality to tumors. Mechanisms governing…”
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Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive by Kanduri, C, Pant, V, Loukinov, D, Pugacheva, E, Qi, C F, Wolffe, A, Ohlsson, R, Lobanenkov, V V

“…In mammals, a subset of genes inherit gametic marks that establish parent of origin-dependent expression patterns in the soma ([1] and references therein). The…”
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Allele-Specific Binding of CTCF to the Multipartite Imprinting Control Region KvDMR1 by Fitzpatrick, Galina V., Pugacheva, Elena M., Shin, Jong-Yeon, Abdullaev, Ziedulla, Yang, Youwen, Khatod, Kavita, Lobanenkov, Victor V., Higgins, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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