Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy

The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and s...

Full description

Saved in:

Bibliographic Details
Published in:	Anais da Academia Brasileira de Ciências Vol. 91; no. 2; p. e20170652
Main Authors:	Lobão, Walder J M, Carvalho, Rosana C C DE, Leite, Sandra A M, Rodrigues, Vandilson P, Batista, José Eduardo, Gomes-Filho, Isaac S, Pereira, Antonio L A
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Ciências 01-01-2019
Subjects:	C-reactive protein Chronic periodontitis Inflammation mediators Interleukin-6 Leukocytes MULTIDISCIPLINARY SCIENCES C-reactive protein Leukocytes Chronic periodontitis Inflammation mediators Interleukin-6
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and serum biomarkers (CRP, IL-6, albumin and percentage of leukocytes) after non-surgical periodontal therapy in systemically healthy adults. An interventional study was conducted with a sample of 29 individuals without CP (control group) and 33 with CP (CP group). Periodontal clinical variables were recorded, and the serum levels of inflammatory markers were measured. Statistical analysis included the chi-square and Student's t-tests and Pearson's correlation analysis. After 90 days of non-surgical periodontal treatment, a reduction of periodontal parameters and IL-6 in both groups could be observed (P < 0.001). The correlation analysis revealed a directly proportional correlation between changes in the probing depth (r = 0.349, P = 0.049) and clinical attachment level (r = 0.374, P = 0.034) with CRP in the CP group. The findings suggest a reduction of IL-6 serum concentration and periodontal clinical measures 90 days after periodontal therapy in both groups.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-3765 1678-2690 1678-2690
DOI:	10.1590/0001-3765201920170652