Search Results - "LoTurco, J J"

The multipolar stage and disruptions in neuronal migration by LOTURCO, Joseph J, JILIN BAI

“…The genetic basis is now known for several disorders of neuronal migration in the developing cerebral cortex. Identification of the cellular processes mediated…”
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Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability by Soh, Heun, Pant, Rima, LoTurco, Joseph J, Tzingounis, Anastasios V

“…KCNQ2 and KCNQ3 potassium channels have emerged as central regulators of pyramidal neuron excitability and spiking behavior. However, despite an abundance of…”
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Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes by Glasgow, Stacey M, Zhu, Wenyi, Stolt, C Claus, Huang, Teng-Wei, Chen, Fuyi, LoTurco, Joseph J, Neul, Jeffrey L, Wegner, Michael, Mohila, Carrie, Deneen, Benjamin

“…Sox10 and Nuclear Factor I-A (NFIA) are transcriptional regulators of oligodendrocyte and astrocyte generation in the mammalian brain, respectively. This study…”
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Electrophysiological Differentiation of New Neurons in the Olfactory Bulb by Belluzzi, Ottorino, Benedusi, Mascia, Ackman, James, LoTurco, Joseph J

“…The subventricular zone produces neuroblasts that migrate to the olfactory bulb (OB) and differentiate into interneurons throughout postnatal life (Altman and…”
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Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses by Maher, Brady J, LoTurco, Joseph J

“…The pathophysiology of schizophrenia is believed to involve defects in synaptic transmission, and the function of many schizophrenia-associated genes,…”
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RNAi reveals doublecortin is required for radial migration in rat neocortex by LoTurco, Joseph J, Bai, Jilin, Ramos, Raddy L, Ackman, James B, Thomas, Ankur M, Lee, Richard V

“…Mutations in the doublecortin gene (DCX) in humans cause malformation of the cerebral neocortex. Paradoxically, genetic deletion of Dcx in mice does not cause…”
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Mechanistic studies of the genetically encoded fluorescent protein voltage probe ArcLight by Han, Zhou, Jin, Lei, Chen, Fuyi, Loturco, Joseph J, Cohen, Lawrence B, Bondar, Alexey, Lazar, Josef, Pieribone, Vincent A

“…ArcLight, a genetically encoded fluorescent protein voltage probe with a large ΔF/ΔV, is a fusion between the voltage sensing domain of the Ciona instestinalis…”
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ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2 by Girgenti, Matthew J, LoTurco, Joseph J, Maher, Brady J

“…ZNF804a was identified by a genome-wide association study (GWAS) in which a single nucleotide polymorphism (SNP rs1344706) in ZNF804a reached genome-wide…”
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Olig2-dependent developmental fate switch of NG2 cells by Zhu, Xiaoqin, Zuo, Hao, Maher, Brady J, Serwanski, David R, LoTurco, Joseph J, Lu, Q Richard, Nishiyama, Akiko

“…NG2-expressing cells (NG2 cells or polydendrocytes) generate oligodendrocytes throughout the CNS and a subpopulation of protoplasmic astrocytes in the gray…”
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Disruption of Neuronal Migration by RNAi of Dyx1c1 Results in Neocortical and Hippocampal Malformations by Rosen, Glenn D., Bai, Jilin, Wang, Yu, Fiondella, Christopher G., Threlkeld, Steven W., LoTurco, Joseph J., Galaburda, Albert M.

“…The brains of individuals with developmental dyslexia have neocortical neuronal migration abnormalities including molecular layer heterotopias, laminar…”
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DCDC2 Mutations Cause a Renal-Hepatic Ciliopathy by Disrupting Wnt Signaling by Schueler, Markus, Braun, Daniela A., Chandrasekar, Gayathri, Gee, Heon Yung, Klasson, Timothy D., Halbritter, Jan, Bieder, Andrea, Porath, Jonathan D., Airik, Rannar, Zhou, Weibin, LoTurco, Joseph J., Che, Alicia, Otto, Edgar A., Böckenhauer, Detlef, Sebire, Neil J., Honzik, Tomas, Harris, Peter C., Koon, Sarah J., Gunay-Aygun, Meral, Saunier, Sophie, Zerres, Klaus, Bruechle, Nadina Ortiz, Drenth, Joost P.H., Pelletier, Laurence, Tapia-Páez, Isabel, Lifton, Richard P., Giles, Rachel H., Kere, Juha, Hildebrandt, Friedhelm

“…Nephronophthisis-related ciliopathies (NPHP-RC) are recessive diseases characterized by renal dysplasia or degeneration. We here identify mutations of DCDC2 as…”
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Disordered breathing in a mouse model of Dravet syndrome by Kuo, Fu-Shan, Cleary, Colin M, LoTurco, Joseph J, Chen, Xinnian, Mulkey, Daniel K

“…Dravet syndrome (DS) is a form of epilepsy with a high incidence of sudden unexpected death in epilepsy (SUDEP). Respiratory failure is a leading cause of…”
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Knockdown of the dyslexia-associated gene Kiaa0319 impairs temporal responses to speech stimuli in rat primary auditory cortex by Centanni, T M, Booker, A B, Sloan, A M, Chen, F, Maher, B J, Carraway, R S, Khodaparast, N, Rennaker, R, LoTurco, J J, Kilgard, M P

“…One in 15 school age children have dyslexia, which is characterized by phoneme-processing problems and difficulty learning to read. Dyslexia is associated with…”
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Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder by LoTurco, Joseph J, Manent, Jean-Bernard, Wang, Yu, Chang, YoonJeung, Paramasivam, Murugan

“…Aberrant neuronal migration during development leads to defects in cortical development and to an increased seizure susceptibility. Now, Joseph LoTurco and his…”
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New and Improved Tools for In Utero Electroporation Studies of Developing Cerebral Cortex by LoTurco, Joseph, Manent, Jean-Bernard, Sidiqi, Faez

“…In utero electroporation (IUE) has become a method of choice for rapid gain and loss of function studies in embryonic cerebral cortex. In this review we…”
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Fate mapping by piggyBac transposase reveals that neocortical GLAST+ progenitors generate more astrocytes than Nestin+ progenitors in rat neocortex by Siddiqi, Faez, Chen, Fuyi, Aron, Abraham W, Fiondella, Christopher G, Patel, Komal, LoTurco, Joseph J

“…Progenitors within the neocortical ventricular zone (VZ) first generate pyramidal neurons and then astrocytes. We applied novel piggyBac transposase lineage…”
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DYX1C1 functions in neuronal migration in developing neocortex by Wang, Y., Paramasivam, M., Thomas, A., Bai, J., Kaminen-Ahola, N., Kere, J., Voskuil, J., Rosen, G.D., Galaburda, A.M., Loturco, J.J.

“…Rodent homologues of two candidate dyslexia susceptibility genes, Kiaa0319 and Dcdc2, have been shown to play roles in neuronal migration in developing…”
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DCDC2 Is Associated with Reading Disability and Modulates Neuronal Development in the Brain by Haiying Meng, Smith, Shelley D., Karl Hager, Held, Matthew, Jonathan Liu, Olson, Richard K., Pennington, Bruce F., DeFries, John C., Gelernter, Joel, Thomas O'Reilly-Pol, Somlo, Stefan, Skudlarski, Pawel, Shaywitz, Sally E., Shaywitz, Bennett A., Karen Marchione, Wang, Yu, Murugan Paramasivam, LoTurco, Joseph J., Page, Grier P., Jeffrey R. Gruen

“…DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide…”
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Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding by Malyshev, Aleksey, Goz, Roman, LoTurco, Joseph J, Volgushev, Maxim

“…Understanding single-neuron computations and encoding performed by spike-generation mechanisms of cortical neurons is one of the central challenges for cell…”
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Evaluation of visual motion perception ability in mice with knockout of the dyslexia candidate susceptibility gene Dcdc2 by Rendall, A. R., Perrino, P. A., LoTurco, J. J., Fitch, R. H.

“…Developmental dyslexia is a heritable disability characterized by difficulties in learning to read and write. The neurobiological and genetic mechanisms…”
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