Search Results - "LoPresti, J"

Molecular imaging of microglia/macrophages in the brain by Venneti, Sriram, Lopresti, Brian J., Wiley, Clayton A.

“…Neuroinflammation perpetuates neuronal damage in many neurological disorders. Activation of resident microglia and infiltration of monocytes/macrophages…”
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The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging by Venneti, Sriram, Lopresti, Brian J, Wiley, Clayton A

“…Microglia constitute the primary resident immune surveillance cell in the brain and are thought to play a significant role in the pathogenesis of several…”
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Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach by Royse, Sarah K, Minhas, Davneet S, Lopresti, Brian J, Murphy, Alice, Ward, Tyler, Koeppe, Robert A, Bullich, Santiago, DeSanti, Susan, Jagust, William J, Landau, Susan M

“…Inconsistent positivity thresholds, image analysis pipelines, and quantitative outcomes are key challenges of multisite studies using more than one β-amyloid…”
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Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials by Cui, Chendi, Birru, Rahel L, Snitz, Beth E, Ihara, Masafumi, Kakuta, Chikage, Lopresti, Brian J, Aizenstein, Howard J, Lopez, Oscar L, Mathis, Chester A, Miyamoto, Yoshihiro, Kuller, Lewis H, Sekikawa, Akira

“…Abstract Context The results of preclinical and observational studies support the beneficial effect of soy isoflavones on cognition. Objective This review…”
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Clinical Impact of Thyroglobulin (Tg) and Tg Autoantibody Method Differences on the Management of Patients with Differentiated Thyroid Carcinomas by Spencer, C. A., Bergoglio, L. M., Kazarosyan, M., Fatemi, S., LoPresti, J. S.

“…Context: Changes in thyroglobulin (Tg) and/or Tg antibody (TgAb) methods can disrupt the serial monitoring of differentiated thyroid carcinoma (DTC) patients…”
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Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease by Ikonomovic, Milos D., Klunk, William E., Abrahamson, Eric E., Mathis, Chester A., Price, Julie C., Tsopelas, Nicholas D., Lopresti, Brian J., Ziolko, Scott, Bi, Wenzhu, Paljug, William R., Debnath, Manik L., Hope, Caroline E., Isanski, Barbara A., Hamilton, Ronald L., DeKosky, Steven T.

“…The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ)…”
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Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens by LING LIN, Philana, COLEMAN, Teresa, KLEIN, Edwin, BARRY, Clifton E, FLYNN, Joanne L, CARNEY, Jonathan P. J, LOPRESTI, Brian J, TOMKO, Jaime, FILLMORE, Dan, DARTOIS, Veronique, SCANGA, Charles, FRYE, L. James, JANSSEN, Christopher

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia by BOHNEN, Nicolaas I, KAUFER, Daniel I, HENDRICKSON, Rick, IVANCO, Larry S, LOPRESTI, Brian J, CONSTANTINE, Gregory M, MATHIS, Chester A, DAVIS, James G, MOORE, Robert Y, DEKOSKY, Steven T

“…We recently reported findings that loss of cortical acetylcholinesterase (AChE) activity is greater in parkinsonian dementia than in Alzheimer's disease (AD)…”
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Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B by Price, Julie C, Klunk, William E, Lopresti, Brian J, Lu, Xueling, Hoge, Jessica A, Ziolko, Scott K, Holt, Daniel P, Meltzer, Carolyn C, DeKosky, Steven T, Mathis, Chester A

“…A valid quantitative imaging method for the measurement of amyloid deposition in humans could improve Alzheimer's disease (AD) diagnosis and antiamyloid…”
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Amyloid Deposition Begins in the Striatum of Presenilin-1 Mutation Carriers from Two Unrelated Pedigrees by Klunk, William E, Price, Julie C, Mathis, Chester A, Tsopelas, Nicholas D, Lopresti, Brian J, Ziolko, Scott K, Bi, Wenzhu, Hoge, Jessica A, Cohen, Ann D, Ikonomovic, Milos D, Saxton, Judith A, Snitz, Beth E, Pollen, Daniel A, Moonis, Majaz, Lippa, Carol F, Swearer, Joan M, Johnson, Keith A, Rentz, Dorene M, Fischman, Alan J, Aizenstein, Howard J, DeKosky, Steven T

“…The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-beta protein is an initiating event in Alzheimer's disease (AD). Using…”
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Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET by Chen, Yin J, Rosario, Bedda L, Mowrey, Wenzhu, Laymon, Charles M, Lu, Xueling, Lopez, Oscar L, Klunk, William E, Lopresti, Brian J, Mathis, Chester A, Price, Julie C

“…The primary goal of this study was to assess the suitability of (11)C-Pittsburgh compound B ((11)C-PiB) blood-brain barrier delivery (K1) and relative delivery…”
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First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis by Villemagne, Victor L, Harada, Ryuichi, Doré, Vincent, Furumoto, Shozo, Mulligan, Rachel, Kudo, Yukitsuka, Burnham, Samantha, Krishnadas, Natasha, Bozinovski, Svetlana, Huang, Kun, Lopresti, Brian J, Yanai, Kazuhiko, Rowe, Christopher C, Okamura, Nobuyuki

“…Reactive gliosis, characterized by reactive astrocytes and activated microglia, contributes greatly to neurodegeneration throughout the course of Alzheimer…”
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Development of Positron Emission Tomography β-Amyloid Plaque Imaging Agents by Mathis, Chester A., PhD, Mason, N. Scott, PhD, Lopresti, Brian J., BS, Klunk, William E., MD, PhD

“…For 100 years, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) have been recognized as the neuropathological hallmarks of Alzheimer's disease (AD),…”
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Association between lower body temperature and increased tau pathology in cognitively normal older adults by Blessing, Esther M., Parekh, Ankit, Betensky, Rebecca A., Babb, James, Saba, Natalie, Debure, Ludovic, Varga, Andrew W., Ayappa, Indu, Rapoport, David M., Butler, Tracy A., de Leon, Mony J., Wisniewski, Thomas, Lopresti, Brian J., Osorio, Ricardo S.

“…Preclinical studies suggest body temperature (Tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in…”
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Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories by Lopresti, Brian J., Campbell, Elizabeth M., Yu, Zheming, Anderson, Stewart J., Cohen, Ann D., Minhas, Davneet S., Snitz, Beth E., Royse, Sarah K., Becker, Carl R., Aizenstein, Howard J., Mathis, Chester A., Lopez, Oscar L., Klunk, William E., Tudorascu, Dana L.

“…To characterize the influence of apolipoprotein-E (APOE) genotype on cerebral Aβ load and longitudinal Aβ trajectories, [11C]Pittsburgh compound-B (PiB)…”
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Radiosynthesis, In Vitro and In Vivo Evaluation of [18F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies by Lindberg, Anton, Knight, Ashley C, Sohn, Daniel, Rakos, Laszlo, Tong, Junchao, Radelet, April, Mason, N. Scott, Stehouwer, Jeffrey S, Lopresti, Brian J, Klunk, William E, Sandell, Johan, Sandberg, Alexander, Hammarström, Per, Svensson, Samuel, Mathis, Chester A, Vasdev, Neil

“…CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays…”
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Imaging dopamine transmission in the frontal cortex: a simultaneous microdialysis and [11C]FLB 457 PET study by Narendran, R, Jedema, H P, Lopresti, B J, Mason, N S, Gurnsey, K, Ruszkiewicz, J, Chen, C-M, Deuitch, L, Frankle, W G, Bradberry, C W

“…In a recent human positron emission tomography (PET) study we demonstrated the ability to detect amphetamine-induced dopamine (DA) release in the prefrontal…”
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Cocaine abuse in humans is not associated with increased microglial activation: an 18-kDa translocator protein positron emission tomography imaging study with [11C]PBR28 by Narendran, Rajesh, Lopresti, Brian J, Mason, Neale Scott, Deuitch, Lora, Paris, Jennifer, Himes, Michael L, Kodavali, Chowdari V, Nimgaonkar, Vishwajit L

“…Basic science investigations have consistently shown that repeated exposure to psychostimulant drugs, such as cocaine, activate the immune response and lead to…”
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PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET by Venneti, Sriram, Lopresti, Brian J, Wang, Guoji, Hamilton, Ronald L, Mathis, Chester A, Klunk, William E, Apte, Udayan M, Wiley, Clayton A

“…Abstract Activated microglia may promote neurodegeneration in Alzheimer's disease (AD) and may also help in amyloid clearance in immunization therapies. In…”
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Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline by Mizuno, Akiko, Karim, Helmet Talib, Ly, Maria J, Lopresti, Brian J, Cohen, Ann D, Ali, Areej A, Mathis, Chester A, Klunk, William E, Aizenstein, Howard J, Snitz, Beth E

“…Subjective cognitive decline (SCD) may represent the earliest preclinical stage of Alzheimer's Disease (AD) for some older adults. However, the underlying…”
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