Search Results - "LoBuglio, A"

Treatment of Patients With Low-Grade B-Cell Lymphoma With the Combination of Chimeric Anti-CD20 Monoclonal Antibody and CHOP Chemotherapy by CZUCZMAN, M. S, GRILLA-LOPEZ, A. J, WHITE, C. A, SALEH, M, GORDON, L, LOBUGLIO, A. F, JONAS, C, KLIPPENSTEIN, D, DALLAIRE, B, VARNS, C

“…To determine the safety and efficacy of the combination of the chimeric anti-CD20 antibody, Rituxan (Rituximab, IDEC-C2B8; IDEC Pharmaceuticals Corporation,…”
Get full text

Phase I Study of Anti–Epidermal Growth Factor Receptor Antibody Cetuximab in Combination With Radiation Therapy in Patients With Advanced Head and Neck Cancer by ROBERT, Francisco, EZEKIEL, Mark P, COOPER, Michael R, WAKSAL, Harlan W, SPENCER, Sharon A, MEREDITH, Ruby F, BONNER, James A, KHAZAELI, M. B, SALEH, Mansoor N, CAREY, Delicia, LOBUGLIO, Albert F, WHEELER, Richard H

“…To evaluate the safety, pharmacokinetics, and efficacy of a chimeric anti-epidermal growth factor receptor monoclonal antibody, cetuximab, in combination with…”
Get full text

PO-487 Prognosis of triple negative breast cancer is associated with MHC II genes by Li, Y, Zhao, A, Bond, GB, Varley, K, Forero, A, Lobuglio, A

“…IntroductionTriple negative breast cancer (TNBC) is clinically to denote women with invasive breast cancer whose tumours lack expression of oestrogen receptor…”
Get full text

A pilot study of the anti-CD20 monoclonal antibody rituximab in patients with refractory immune thrombocytopenia by Saleh, M N, Gutheil, J, Moore, M, Bunch, P W, Butler, J, Kunkel, L, Grillo-López, A J, LoBuglio, A F

“…We conducted a prospective pilot phase I/II clinical trial to evaluate the toxicity and response rate of the chimeric anti-CD20 monoclonal antibody, rituximab…”
Get more information

Clearing of cells bearing the bcl-2 [t(14;18)] translocation from blood and marrow of patients treated with rituximab alone or in combination with CHOP chemotherapy by Czuczman, M. S., Grillo-López, A. J., McLaughlin, P., White, C. A., Saleh, M., Gordon, L., LoBuglio, A. F., Rosenberg, J., Alkuzweny, B., Maloney, D.

“…Purpose Patients who were PCR-positive for B-cell leukemialymphoma 2 (bcl-2) gene rearrangement [t(14,18)] were evaluated for responses to rituximab alone or…”
Get full text

Characterization of a messenger RNA polynucleotide vaccine vector by CONRY, R. M, LOBUGLIO, A. F, WRIGHT, M, SUMEREL, L, PIKE, M. J, JOHANNING, F, BEJAMIN, R, DAN LU, CURIEL, D. T

“…We have constructed mRNA transcripts encoding luciferase and human carcinoembryonic antigen (CEA) which are capped, polyadenylated, and stabilized by human…”
Get full text

Mouse/Human Chimeric Monoclonal Antibody in Man: Kinetics and Immune Response by LoBuglio, Albert F., Wheeler, Richard H., Trang, John, Haynes, Amy, Rogers, Kim, Harvey, Elizabeth B., Sun, Lee, Ghrayeb, John, Khazaeli, M. B.

“…A mouse/human chimeric monoclonal antibody (mAb) composed of the variable regions of murine 17-1A mAb and the constant regions of human IgG-1K immunoglobulin…”
Get full text

Long Term Outcome of Intraperitoneal Radioimmunotherapy for Ovarian Cancer by Meredith, R.F, Alvarez, R, Huh, W, Partridge, E, Grizzle, W, LoBuglio, A

Get full text

Human Autoantibodies to Carcinoembryonic Antigen (CEA) Induced by a Vaccinia-CEA Vaccine by CONRY, R. M, ALLEN, K. O, LEE, S.-W, MOORE, S. E, SHAW, D. R, LOBUGLIO, A. F

“…Carcinoembryonic antigen (CEA) is a well-characterized oncofetal glycoprotein whose overexpression by human adenocarcinomas has been a target for cancer…”
Get full text

Phase I Trial of a Recombinant Vaccinia Virus Encoding Carcinoembryonic Antigen in Metastatic Adenocarcinoma: Comparison of Intradermal versus Subcutaneous Administration by CONRY, R. M, KHAZAELI, M. B, SALEH, M. N, ALLEN, K. O, BARLOW, D. L, MOORE, S. E, CRAIG, D, ARANI, R. B, SCHLOM, J, LOBUGLIO, A. F

“…The principal objectives of this trial were twofold: ( a ) to examine the safety and relative efficacy of intradermal needle injection versus s.c. jet…”
Get full text

Expression of Human Endogenous Retrovirus K Envelope Transcripts in Human Breast Cancer by Wang-Johanning, F, Frost, A R, Johanning, G L, Khazaeli, M B, LoBuglio, A F, Shaw, D R, Strong, T V

“…Purpose: We investigated the expression of human endogenous retroviral (HERV) sequences in breast cancer. Experimental Design: Reverse transcription-PCR…”
Get full text

Enhanced Apoptosis With Combination C225/Radiation Treatment Serves as the Impetus for Clinical Investigation in Head and Neck Cancers by BONNER, James A, RAISCH, Kevin P, PETERS, Glenn E, CARROLL, William R, WAKSAL, Harlan W, TRUMMELL, Hoa Q, ROBERT, Francisco, MEREDITH, Ruby F, SPENCER, Sharon A, BUCHSBAUM, Donald J, SALEH, Mansoor N, STACKHOUSE, Murray A, LOBUGLIO, Albert F

“…Epidermal growth factor receptor (EGFr) is overexpressed in a majority of head and neck squamous cell carcinomas, and this overexpression is associated with a…”
Get full text

CD16+ Monocytes in Patients With Cancer: Spontaneous Elevation and Pharmacologic Induction by Recombinant Human Macrophage Colony-Stimulating Factor by Saleh, Mansoor N., Goldman, Samuel J., LoBuglio, Albert F., Beall, Arthur C., Sabio, Hernan, McCord, Melissa C., Minasian, Lori, Alpaugh, R.Katherine, Weiner, Louis M., Munn, David H.

“…The small subset of circulating monocytes that express the maturation-associated CD 16 antigen has recently been reported to be elevated in patients with…”
Get full text

Phase I Trial of the Anti–Lewis Y Drug Immunoconjugate BR96-Doxorubicin in Patients With Lewis Y–Expressing Epithelial Tumors by Saleh, M N, Sugarman, S, Murray, J, Ostroff, J B, Healey, D, Jones, D, Daniel, C R, LeBherz, D, Brewer, H, Onetto, N, LoBuglio, A F

“…We conducted a phase I clinical trial of BR96-Doxorubicin (BR96-Dox), a chimeric anti-Lewis Y (Le(Y)) monoclonal antibody conjugated to doxorubicin, in…”
Get full text

Selected strategies to augment polynucleotide immunization by Conry, R M, Widera, G, LoBuglio, A F, Fuller, J T, Moore, S E, Barlow, D L, Turner, J, Yang, N S, Curiel, D T

“…We sought to amplify the immune response to polynucleotide immunization through co-delivery of complementary DNA (cDNA) encoding a cytokine or co-stimulatory…”
Get more information

Immune response to a carcinoembryonic antigen polynucleotide vaccine by CONRY, R. M, LOBUGLIO, A. F, KANTOR, J, SCHLOM, J, LOECHEL, F, MOORE, S. E, SUMEREL, L. A, BARLOW, D. L, ABRAMS, S, CURIEL, D. T

“…We have constructed a DNA plasmid encoding the full length complementary DNA for human carcinoembryonic antigen (CEA) driven by the cytomegalovirus early…”
Get full text

Treatment of Metastatic Prostate Carcinoma with Radiolabeled Antibody CC49 by Meredith, Ruby F, Bueschen, Anton J, Khazaeli, M.B, Plott, Walter E, Grizzle, William E, Wheeler, Richard H, Schlom, Jeffrey, Russell, Charles D, Liu, Tiepu, LoBuglio, Albert F

“…A Phase II trial of 75 mCi/m2 131I-anti-TAG-72 high-affinity antibody CC49 was studied in 15 patients with hormone-resistant metastatic prostate cancer…”
Get full text

A sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo by Johanning, F. W., Conry, R. M., LoBuglio, A. F., Wright, M., Sumerel, L. A., Pike, M. J., Curiel, D. T.

“…The direct Intramuscular delivery of naked plasmld DNA has been demonstrated to allow expression of encoded heterologous genes in the target myocytes. The…”
Get full text

Phagocyte-generated oxygen metabolites and cellular injury by Weiss, S J, LoBuglio, A F

“…Phagocytic leukocytes are motile cells capable of inducing damage and lysis of a wide variety of biologic targets. Recent insights into the mechanisms of…”
Get more information

Human immune response to monoclonal antibodies by Khazaeli, M B, Conry, R M, LoBuglio, A F

“…Monoclonal antibodies either of mouse, mouse/human chimeric, or human origin have been used safely in human trials for a decade. Considerable effort has been…”
Get more information