Search Results - "Lo Bello, Mario"

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1 by De Luca, Anastasia, Parker, Lorien J., Ang, Wee Han, Rodolfo, Carlo, Gabbarini, Valentina, Hancock, Nancy C., Palone, Francesca, Mazzetti, Anna P., Menin, Laure, Morton, Craig J., Parker, Michael W., Lo Bello, Mario, Dyson, Paul J.

“…Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However,…”
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Rational Design of an Organometallic Glutathione Transferase Inhibitor by Ang, Wee Han, Parker, Lorien J, De Luca, Anastasia, Juillerat-Jeanneret, Lucienne, Morton, Craig J, Lo Bello, Mario, Parker, Michael W, Dyson, Paul J

“…Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct…”
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Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation by Parker, Lorien J., Italiano, Louis C., Morton, Craig J., Hancock, Nancy C., Ascher, David B., Aitken, Jade B., Harris, Hugh H., Campomanes, Pablo, Rothlisberger, Ursula, De Luca, Anastasia, Lo Bello, Mario, Ang, Wee Han, Dyson, Paul J., Parker, Michael W.

“…Platinum‐based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their…”
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Organometallic Ruthenium Inhibitors of Glutathione-S-Transferase P1-1 as Anticancer Drugs by Ang, Wee Han, De Luca, Anastasia, Chapuis-Bernasconi, Catherine, Juillerat-Jeanneret, Lucienne, Lo Bello, Mario, Dyson, Paul J.

“…Ruthenium–arene complexes conjugated to ethacrynic acid were prepared as part of a strategy to develop novel glutathione‐S‐transferase (GST) inhibitors with…”
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Nitrosylation of Human Glutathione Transferase P1-1 with Dinitrosyl Diglutathionyl Iron Complex in Vitro and in Vivo by Cesareo, Eleonora, Parker, Lorien J., Pedersen, Jens Z., Nuccetelli, Marzia, Mazzetti, Anna P., Pastore, Anna, Federici, Giorgio, Caccuri, Anna M., Ricci, Giorgio, Adams, Julian J., Parker, Michael W., Bello, Mario Lo

“…We have recently shown that dinitrosyl diglutathionyl iron complex, a possible in vivo nitric oxide (NO) donor, binds with extraordinary affinity to one of the…”
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Glutathione transferases and neurodegenerative diseases by Mazzetti, Anna Paola, Fiorile, Maria Carmela, Primavera, Alessandra, Lo Bello, Mario

“…•Association between glutathione depletion and PD or AD has been proposed.•There is a significant decrease of GST activity in the brain of PD patients.•Some…”
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Glutathione Transferases and Glutathionylated Hemoglobin in Workers Exposed to Low Doses of 1,3-Butadiene by Primavera, Alessandra, Fustinoni, Silvia, Biroccio, Antonino, Ballerini, Sabrina, Urbani, Andrea, Bernardini, Sergio, Federici, Giorgio, Capucci, Enrico, Manno, Maurizio, Lo Bello, Mario

“…We evaluated glutathione transferase (GST) activities and the levels of glutathionylated hemoglobin in the RBC of 42 workers exposed to 1,3-butadiene in a…”
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Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function by Bocedi, Alessio, Fabrini, Raffaele, Lo Bello, Mario, Caccuri, Anna Maria, Federici, Giorgio, Mannervik, Bengt, Cornish-Bowden, Athel, Ricci, Giorgio

“…Negative cooperativity in enzyme reactions, in which the first event makes subsequent events less favorable, is sometimes well understood at the molecular…”
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Glutathione Transferase Superfamily Behaves Like Storage Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in Heterogeneous Systems by Turella, Paola, Pedersen, Jens Z., Caccuri, Anna Maria, De Maria, Francesca, Mastroberardino, Piergiorgio, Bello, Mario Lo, Federici, Giorgio, Ricci, Giorgio

“…Electron paramagnetic resonance and kinetics experiments have been made to determine the formation, stability, and fate of the natural nitric oxide carrier,…”
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Glutathione transferase P1‐1 as an arsenic drug‐sequestering enzyme by Parker, Lorien J., Bocedi, Alessio, Ascher, David B., Aitken, Jade B., Harris, Hugh H., Lo Bello, Mario, Ricci, Giorgio, Morton, Craig J., Parker, Michael W.

“…Arsenic‐based compounds are paradoxically both poisons and drugs. Glutathione transferase (GSTP1‐1) is a major factor in resistance to such drugs. Here we…”
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Monomer−Dimer Equilibrium in Glutathione Transferases: A Critical Re-Examination by Fabrini, Raffaele, De Luca, Anastasia, Stella, Lorenzo, Mei, Giampiero, Orioni, Barbara, Ciccone, Sarah, Federici, Giorgio, Lo Bello, Mario, Ricci, Giorgio

“…Glutathione transferases (GSTs) are dimeric enzymes involved in cell detoxification versus many endogenous toxic compounds and xenobiotics. In addition, single…”
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Thermodynamic Description of the Effect of the Mutation Y49F on Human Glutathione Transferase P1-1 in Binding with Glutathione and the Inhibitor S-Hexylglutathione by Ortiz-Salmerón, Emilia, Nuccetelli, Marzia, Oakley, Aaron J., Parker, Michael W., Bello, Mario Lo, García-Fuentes, Luis

“…The thermodynamics of binding of both the substrate glutathione (GSH) and the competitive inhibitor S-hexylglutathione to the mutant Y49F of human glutathione…”
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The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force by Bocedi, Alessio, Fabrini, Raffaele, Farrotti, Andrea, Stella, Lorenzo, Ketterman, Albert J, Pedersen, Jens Z, Allocati, Nerino, Lau, Peter C K, Grosse, Stephan, Eltis, Lindsay D, Ruzzini, Antonio, Edwards, Thomas E, Morici, Laura, Del Grosso, Erica, Guidoni, Leonardo, Bovi, Daniele, Lo Bello, Mario, Federici, Giorgio, Parker, Michael W, Board, Philip G, Ricci, Giorgio

“…Glutathione transferases (GSTs) are protection enzymes capable of conjugating glutathione (GSH) to toxic compounds. During evolution an important catalytic…”
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Glutathione S-transferase alpha 1 risk polymorphism and increased bilateral thalamus mean diffusivity in schizophrenia by Spalletta, Gianfranco, Piras, Fabrizio, Gravina, Paolo, Bello, Mario Lo, Bernardini, Sergio, Caltagirone, Carlo

“…Abstract Oxidative damage in brain cells is one of the factors hypothesized to be involved in the pathogenesis of schizophrenia. Glutathione S-transferase…”
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The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants by Parker, Lorien J., Ciccone, Sarah, Italiano, Louis C., Primavera, Alessandra, Oakley, Aaron J., Morton, Craig J., Hancock, Nancy C., Bello, Mario Lo, Parker, Michael W.

“…The commonly used anti-cancer drug chlorambucil is the primary treatment for patients with chronic lymphocytic leukaemia. Chlorambucil has been shown to be…”
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Human Glutathione Transferase T2-2 Discloses Some Evolutionary Strategies for Optimization of Substrate Binding to the Active Site of Glutathione Transferases by Caccuri, Anna Maria, Antonini, Giovanni, Board, Philip G., Flanagan, Jack, Parker, Michael W., Paolesse, Roberto, Turella, Paola, Federici, Giorgio, Bello, Mario Lo, Ricci, Giorgio

“…Rapid kinetic, spectroscopic, and potentiometric studies have been performed on human Theta class glutathione transferase T2-2 to dissect the mechanism of…”
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Electrostatic Association of Glutathione Transferase to the Nuclear Membrane: EVIDENCE OF AN ENZYME DEFENSE BARRIER AT THE NUCLEAR ENVELOPE by Stella, Lorenzo, Pallottini, Valentina, Moreno, Sandra, Leoni, Silvia, De Maria, Francesca, Turella, Paola, Federici, Giorgio, Fabrini, Raffaele, Dawood, Kutayba F, Bello, Mario Lo, Pedersen, Jens Z, Ricci, Giorgio

“…The possible nuclear compartmentalization of glutathione S-transferase (GST) isoenzymes has been the subject of contradictory reports. The discovery that the…”
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Identification of ‘tissue’ transglutaminase binding proteins in neural cells committed to apoptosis by PIREDDA, LUCIA, FARRACE, MARIA GRAZIA, LO BELLO, MARIO, MALORNI, WALTER, MELINO, GENNARO, PETRUZZELLI, RAFFAELE, PIACENTINI, MAURO

“…ABSTRACT Overexpression of ‘tissue’ transglutaminase (tTG) in the human neuroblastoma cells increases spontaneous apoptosis and renders these cells highly…”
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Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V by Quesada-Soriano, Indalecio, Parker, Lorien J., Primavera, Alessandra, Wielens, Jerome, Holien, Jessica K., Casas-Solvas, Juan M., Vargas-Berenguel, Antonio, Aguilera, Ana M., Nuccetelli, Marzia, Mazzetti, Anna P., Bello, Mario Lo, Parker, Michael W., García-Fuentes, Luis

“…The diuretic drug ethacrynic acid (EA), both an inhibitor and substrate of pi class glutathione S‐transferase (GST P1‐1), has been tested in clinical trials as…”
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The ligandin (non-substrate) binding site of human pi class glutathione transferase is located in the electrophile binding site (H-site) by Oakley, Aaron J, Lo Bello, Mario, Nuccetelli, Marzia, Mazzetti, Anna P, Parker, Michael W

“…Glutathione S-transferases (GSTs) play a pivotal role in the detoxification of foreign chemicals and toxic metabolites. They were originally termed ligandins…”
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