Search Results - "Löffek, Stefanie"

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation by Franzke, Claus-Werner, Cobzaru, Cristina, Triantafyllopoulou, Antigoni, Löffek, Stefanie, Horiuchi, Keisuke, Threadgill, David W, Kurz, Thomas, van Rooijen, Nico, Bruckner-Tuderman, Leena, Blobel, Carl P

“…ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR)…”
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Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression by Mittapalli, Venugopal R, Madl, Josef, Löffek, Stefanie, Kiritsi, Dimitra, Kern, Johannes S, Römer, Winfried, Nyström, Alexander, Bruckner-Tuderman, Leena

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven blister formation, progressive…”
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Tension in Cancer by Löffek, Stefanie, Franzke, Claus-Werner, Helfrich, Iris

“…Integrins represent a large family of cell receptors that mediate adhesion to the extracellular matrix (ECM), thereby modulating a variety of cellular…”
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Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer by Moilanen, Jyri M., MD, Kokkonen, Nina, PhD, Löffek, Stefanie, PhD, Väyrynen, Juha P., MD, PhD, Syväniemi, Erkki, MD, Hurskainen, Tiina, PhD, Mäkinen, Markus, MD, PhD, Klintrup, Kai, MD, PhD, Mäkelä, Jyrki, MD, PhD, Sormunen, Raija, PhD, Bruckner-Tuderman, Leena, MD, PhD, Autio-Harmainen, Helena, MD, PhD, Tasanen, Kaisa, MD, PhD

“…Summary Collagen XVII has a well-established role as an adhesion molecule and a cell surface receptor located in the type I hemidesmosome of stratified…”
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Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations by Tholen, Stefan, Wolf, Cristina, Mayer, Bettina, Knopf, Julia D, Löffek, Stefanie, Qian, Yawen, Kizhakkedathu, Jayachandran N, Biniossek, Martin L, Franzke, Claus-Werner, Schilling, Oliver

“…Keratinocyte-specific deletion of ADAM17 in mice impairs terminal differentiation of keratinocytes leading to severe epidermal barrier defects. Mice deficient…”
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Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling by Löffek, Stefanie, Hurskainen, Tiina, Jackow, Joanna, Sigloch, Florian Christoph, Schilling, Oliver, Tasanen, Kaisa, Bruckner-Tuderman, Leena, Franzke, Claus-Werner

“…The hemidesmosomal transmembrane component collagen XVII (ColXVII) plays an important role in the anchorage of the epidermis to the underlying basement…”
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Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells by Moilanen, Jyri M., Löffek, Stefanie, Kokkonen, Nina, Salo, Sirpa, Väyrynen, Juha P., Hurskainen, Tiina, Manninen, Aki, Riihilä, Pilvi, Heljasvaara, Ritva, Franzke, Claus-Werner, Kähäri, Veli-Matti, Salo, Tuula, Mäkinen, Markus J., Tasanen, Kaisa

“…Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are…”
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Targeting of Cell Surface Proteolysis of Collagen XVII Impedes Squamous Cell Carcinoma Progression by Galiger, Célimène, Löffek, Stefanie, Stemmler, Marc P., Kroeger, Jasmin K., Mittapalli, Venugopal R., Fauth, Lisa, Esser, Philipp R., Kern, Johannes S., Meiss, Frank, Laßmann, Silke, Bruckner-Tuderman, Leena, Franzke, Claus-Werner

“…Squamous cell carcinoma (SCC) is one of the most common skin cancers and causes significant morbidity. Although the expression of the epithelial adhesion…”
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Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers by Schöpel, Miriam, Shkura, Oleksandr, Seidel, Jana, Kock, Klaus, Zhong, Xueyin, Löffek, Stefanie, Helfrich, Iris, Bachmann, Hagen S, Scherkenbeck, Jürgen, Herrmann, Christian, Stoll, Raphael

“…The protein family of small GTPases controls cellular processes by acting as a binary switch between an active and an inactive state. The most prominent family…”
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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma by Martins Nascentes Melo, Luiza, Herrera-Rios, Dayana, Hinze, Daniel, Löffek, Stefanie, Oezel, Irem, Turiello, Roberta, Klein, Juliane, Leonardelli, Sonia, Westedt, Isa-Vanessa, Al-Matary, Yahya, Egea-Rodriguez, Sara, Brenzel, Alexandra, Bau, Maja, Sucker, Antje, Hadaschik, Eva, Wirsdörfer, Florian, Hanenberg, Helmut, Uhlenbrock, Niklas, Rauh, Daniel, Poźniak, Joanna, Rambow, Florian, Marine, Jean-Christophe, Effern, Maike, Glodde, Nicole, Schadendorf, Dirk, Jablonska, Jadwiga, Hölzel, Michael, Helfrich, Iris

“…BackgroundImmune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death…”
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Collagen XVII Shedding Suppresses Re-Epithelialization by Directing Keratinocyte Migration and Dampening mTOR Signaling by Jacków, Joanna, Löffek, Stefanie, Nyström, Alexander, Bruckner-Tuderman, Leena, Franzke, Claus-Werner

“…Transmembrane collagen XVII is traditionally viewed as an important hemidesmosomal attachment component that promotes stable dermal-epidermal adhesion in the…”
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ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation by Löffek, Stefanie, Wöll, Stefan, Höhfeld, Jörg, Leube, Rudolf E, Has, Cristina, Bruckner-Tuderman, Leena, Magin, Thomas M

“…Keratin (K) intermediate filament proteins form cytoskeletal scaffolds in epithelia, the disruption of which leads to a large number of human disorders. KRT5…”
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Involvement of the ubiquitin-proteasome system in the stabilization of cell-cell contacts in human keratinocytes by Löffek, Stefanie, Bruckner-Tuderman, Leena, Magin, Thomas M.

“…Desmosomes are highly organized intercellular junctions composed of a number of interacting proteins that provide mechanical integrity to epithelial tissues…”
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MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma by Ullrich, Nico, Löffek, Stefanie, Horn, Susanne, Ennen, Marie, Sánchez-del-Campo, Luis, Zhao, Fang, Breitenbuecher, Frank, Davidson, Irwin, Singer, Bernhard B., Schadendorf, Dirk, Goding, Colin R., Helfrich, Iris

“…Summary The multifunctional Ig‐like carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is neo‐expressed in the majority of malignant melanoma…”
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Transforming of the Tumor Microenvironment: Implications for TGF-β Inhibition in the Context of Immune-Checkpoint Therapy by Löffek, Stefanie

“…Significant breakthroughs have been achieved in the fields of oncogenic signaling inhibition and particularly immune-checkpoint blockade has triggered…”
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Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation by Franzke, Claus-Werner, Cobzaru, Cristina, Triantafyllopoulou, Antigoni, Löffek, Stefanie, Horiuchi, Keisuke, Threadgill, David W., Kurz, Thomas, van Rooijen, Nico, Bruckner-Tuderman, Leena, Blobel, Carl P.

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Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy by Michel, Lars, Helfrich, Iris, Hendgen-Cotta, Ulrike Barbara, Mincu, Raluca-Ileana, Korste, Sebastian, Mrotzek, Simone Maria, Spomer, Armin, Odersky, Andrea, Rischpler, Christoph, Herrmann, Ken, Umutlu, Lale, Coman, Cristina, Ahrends, Robert, Sickmann, Albert, Löffek, Stefanie, Livingstone, Elisabeth, Ugurel, Selma, Zimmer, Lisa, Gunzer, Matthias, Schadendorf, Dirk, Totzeck, Matthias, Rassaf, Tienush

“…Abstract Aims Cardiac immune-related adverse events (irAEs) from immune checkpoint inhibition (ICI) targeting programmed death 1 (PD1) are of growing concern…”
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Treatment with the pure antiestrogen faslodex (ICI 182780) induces tumor necrosis factor receptor 1 (TNFR1) expression in MCF-7 breast cancer cells by SMOLNIKAR, Kai, LOFFEK, Stefanie, SCHULZ, Thorsten, MICHNA, Horst, DIEL, Patrick

“…Apoptosis induction by the pure antiestrogen faslodex, also known as ICI 182780 (ICI), is associated with an effective down-regulation of Bcl-2 expression in…”
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Deletion of the Major Bullous Pemphigoid Epitope Region of Collagen XVII Induces Blistering, Autoimmunization, and Itching in Mice by Hurskainen, Tiina, Kokkonen, Nina, Sormunen, Raija, Jackow, Joanna, Löffek, Stefanie, Soininen, Raija, Franzke, Claus-Werner, Bruckner-Tuderman, Leena, Tasanen, Kaisa

“…Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease with a characteristic of pruritus and blistering. BP patients carry…”
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Transforming of the Tumor Microenvironment: Implications for TGF-[beta] Inhibition in the Context of Immune-Checkpoint Therapy by Loffek, Stefanie

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