Search Results - "Lo, Yvonne"

The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers by Shi, Jack G., Chen, Xuejun, Lee, Fiona, Emm, Thomas, Scherle, Peggy A., Lo, Yvonne, Punwani, Naresh, Williams, William V., Yeleswaram, Swamy

“…Baricitinib (also known as LY3009104 or INCB028050), a novel and potent small molecule inhibitor of Janus kinase family of enzymes (JAKs) with selectivity for…”
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Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms by Quintás-Cardama, Alfonso, Vaddi, Kris, Liu, Phillip, Manshouri, Taghi, Li, Jun, Scherle, Peggy A, Caulder, Eian, Wen, Xiaoming, Li, Yanlong, Waeltz, Paul, Rupar, Mark, Burn, Timothy, Lo, Yvonne, Kelley, Jennifer, Covington, Maryanne, Shepard, Stacey, Rodgers, James D, Haley, Patrick, Kantarjian, Hagop, Fridman, Jordan S, Verstovsek, Srdan

“…Constitutive JAK2 activation in hematopoietic cells by the JAK2V617F mutation recapitulates myeloproliferative neoplasm (MPN) phenotypes in mice, establishing…”
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A short message service (SMS) intervention to prevent diabetes in Chinese professional drivers with pre-diabetes: A pilot single-blinded randomized controlled trial by Wong, Carlos K.H, Fung, Colman S.C, Siu, S.C, Lo, Yvonne Y.C, Wong, K.W, Fong, Daniel Y.T, Lam, Cindy L.K

“…Abstract Aim To determine the efficacy of delivering short-message service (SMS) to provide diabetes-related information in reducing the risk of developing…”
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The Impact of Work Nature, Lifestyle, and Obesity on Health-Related Quality of Life in Chinese Professional Drivers by Wong, Carlos K.H., Fung, Colman S.C., Siu, Shing-Chung, Wong, Ka-Wai, Lee, Ka-Fai, Lo, Yvonne Y.C., Fong, Daniel Y.T., Lam, Cindy L.K.

“…Objective: To assess the association of work nature, lifestyle and obesity with health-related quality of life (HRQOL) in professional drivers. Methods: A…”
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The Pharmacokinetics, Pharmacodynamics, and Safety of Orally Dosed INCB018424 Phosphate in Healthy Volunteers by Shi, Jack G., Chen, Xuejun, McGee, Ryan F., Landman, Robert R., Emm, Thomas, Lo, Yvonne, Scherle, Peggy A., Punwani, Naresh G., Williams, William V., Yeleswaram, Swamy

“…INCB018424 phosphate, a potent inhibitor of JAK enzymes with selectivity for JAK1&2, is in development for the treatment of myelofibrosis (MF). The oral dose…”
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A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity by Rios-Doria, Jonathan, Favata, Margaret, Lasky, Kerri, Feldman, Patricia, Lo, Yvonne, Yang, Gengjie, Stevens, Christina, Wen, Xiaoming, Sehra, Sarita, Katiyar, Kamna, Liu, Ke, Wynn, Richard, Harris, Jennifer J, Ye, Min, Spitz, Susan, Wang, Xiaozhao, He, Chunhong, Li, Yun-Long, Yao, Wenqing, Covington, Maryanne, Scherle, Peggy, Koblish, Holly

“…TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play important roles in tumor growth, survival, cell adhesion, as well as…”
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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer by Zhou, Bin-Bing S., Peyton, Michael, He, Biao, Liu, Changnian, Girard, Luc, Caudler, Eian, Lo, Yvonne, Baribaud, Frederic, Mikami, Iwao, Reguart, Noemi, Yang, Gengjie, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Gazdar, Adi F., Friedman, Steven M., Jablons, David M., Newton, Robert C., Fridman, Jordan S., Minna, John D., Scherle, Peggy A.

“…We describe here the existence of a heregulin-HER3 autocrine loop, and the contribution of heregulin-dependent, HER2-mediated HER3 activation to gefitinib…”
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The associations of body mass index with physical and mental aspects of health-related quality of life in Chinese patients with type 2 diabetes mellitus: results from a cross-sectional survey by Wong, Carlos K H, Lo, Yvonne Y C, Wong, Winnie H T, Fung, Colman S C

“…This study aimed to determine the associations of various clinical factors with generic health-related quality of life (HRQOL) scores among Hong Kong Chinese…”
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Cost-Effectiveness of a Short Message Service Intervention to Prevent Type 2 Diabetes from Impaired Glucose Tolerance by Lam, Cindy Lo Kuen, Lo, Yvonne Y. C., Wong, Ka-Wai, Fong, Daniel Y. T., Fung, Colman S. C., Siu, Shing-Chung, Jiao, Fang-Fang, Wong, Carlos K. H., Yu, Esther Y. T.

“…Aims. To investigate the costs and cost-effectiveness of a short message service (SMS) intervention to prevent the onset of type 2 diabetes mellitus (T2DM) in…”
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Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer by Fridman, Jordan S, Caulder, Eian, Hansbury, Michael, Liu, Xiangdong, Yang, Genjie, Wang, Qian, Lo, Yvonne, Zhou, Bin-Bing, Pan, Maxwell, Thomas, Sufi M, Grandis, Jennifer R, Zhuo, Jincong, Yao, Wenqing, Newton, Robert C, Friedman, Steven M, Scherle, Peggy A, Vaddi, Kris

“…Purpose: ErbB receptor signaling pathways are important regulators of cell fate, and their dysregulation, through (epi)genetic alterations, plays an etiologic…”
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Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells by Chen, Yaoyu, Favata, Margaret, Pusey, Michelle, Li, Jun, Lo, Yvonne, Ye, Min, Wynn, Richard, Wang, Xiaozhao, Yao, Wenqing, Chen, Yingnan

“…The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest-specific protein 6 (GAS6)-induced MER phosphorylation is…”
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Brief problem-solving treatment in primary care (pst-pc) was not more effective than placebo for elderly patients screened positive of psychological problems by Lam, Cindy L. K., Fong, Daniel Y. T., Chin, Weng-Yee, Lee, Peter W. H., Lam, Elegance T. P., Lo, Yvonne Y. C.

“…Objectives To evaluate whether screening followed by brief problem‐solving treatment by primary care doctors (PST‐PC) could improve health‐related quality of…”
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Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2 by Shin, Niu, Baribaud, Frédéric, Wang, Kathy, Yang, Genjie, Wynn, Rich, Covington, Maryanne B., Feldman, Patricia, Gallagher, Karen B., Leffet, Lynn M., Lo, Yvonne Y., Wang, Anlai, Xue, Chu-Biao, Newton, Robert C., Scherle, Peggy A.

“…The chemokine receptor 2 (CCR2) directs migration of monocytes and has been proposed to be a drug target for chronic inflammatory diseases. INCB3344 was first…”
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Unrecognised psychological problems impair quality of life and increase consultation rates in Chinese elderly patients by Lam, Cindy L. K., Chin, Weng Yee, Lee, Peter W. H., Lo, Yvonne Y. C., Fong, Daniel Y. T., Lam, Tai Pong

“…Objective Studies have shown that psychological problems in elderly patients are often unrecognised in primary care. The aim of this study was to investigate…”
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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists by Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Nelson, David J, Lo, Yvonne C, Yang, Gengjie, Scherle, Peggy A, Mandlekar, Sandhya, Wasserman, Zelda R, Jezak, Heather, Solomon, Kimberly A, Tebben, Andrew J, Carter, Percy H, Decicco, Carl P

“…We describe the design, synthesis, and evaluation of novel disubstituted cyclohexanes as potent CCR2 antagonists. Exploratory SAR studies led to the…”
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Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J., Brogan, John B., Mo, Ruowei, Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Molino, Bruce F., Carter, Percy H., Decicco, Carl P.

“…A series of trisubstituted cyclohexanes was designed, synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the identification…”
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Does vocational training in family medicine have an impact on antibiotic prescribing pattern? by Lo, Yvonne Y C, Lam, C L K, Mercer, S W, Fong, D Y T

“…Antibiotics overuse is common and is the major cause of antibiotic resistance. Rational use of antibiotics by GPs is essential as most health problems are…”
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Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone by Carter, Percy H., Brown, Gregory D., King, Sarah R., Voss, Matthew E., Tebben, Andrew J., Cherney, Robert J., Mandlekar, Sandhya, Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Zhao, Qihong, Decicco, Carl P.

“…We describe an isostere-driven approach to improve upon a previously-described series of capped dipeptide antagonists of CC Chemokine Receptor 2 (CCR2)…”
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Having a Family Doctor is Associated with Some Better Patient-Reported Outcomes of Primary Care Consultations by Lam, Cindy L K, Yu, Esther Y T, Lo, Yvonne Y C, Wong, Carlos K H, Mercer, Stewart M, Fong, Daniel Y T, Lee, Albert, Lam, Tai Pong, Leung, Gabriel M

“…Hong Kong (HK) has pluralistic primary care that is provided by a variety of doctors. The aim of our study was to assess patient-reported outcomes of primary…”
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Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J., Mo, Ruowei, Meyer, Dayton T., Pechulis, Anthony D., Guaciaro, Michael A., Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Zhao, Qihong, Cvijic, Mary Ellen, Barrish, Joel C., Decicco, Carl P., Carter, Percy H.

“…We describe the design, synthesis, and evaluation of benzimidazoles as benzamide replacements within a series of trisubstituted cyclohexane CCR2 antagonists…”
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