Search Results - "Lo, Michael M.‐C."

A Library of Spirooxindoles Based on a Stereoselective Three-Component Coupling Reaction by Lo, Michael M.-C, Neumann, Christopher S, Nagayama, Satoshi, Perlstein, Ethan O, Schreiber, Stuart L

“…A collection of structurally complex and chemically diverse small molecules is a useful tool to explore cell circuitry. In this article, we report the…”
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Stereodivergent Synthesis of 3‐Hydroxyprolines and 3‐Hydroxypipecolic Acids via Ketoreductase‐Catalyzed Dynamic Kinetic Reduction by Prier, Christopher K., Lo, Michael M.‐C., Li, Hongming, Yasuda, Nobuyoshi

“…We report a practical enzymatic approach for the stereoselective synthesis of hydroxylated cyclic amino acids. Using ketoreductases, cyclic ketoesters are…”
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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity by Sebhat, Iyassu K, Franklin, Christopher, Lo, Michael M.-C, Chen, David, Jewell, James P, Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M, Guan, Xiao-Ming, Marsh, Donald J, Kosinski, Jennifer A, Metzger, Joseph M, Lyons, Kathryn, Dragovic, Jasminka, Guzzo, Peter R, Henderson, Alan J, Reitman, Marc L, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S

“…We report the development and characterization of compound 22 (MK-5046), a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3). In…”
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Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists by Lo, Michael M.-C., Chobanian, Harry R., Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M., Guan, Xiao-Ming, Reitman, Marc L., Dragovic, Jasminka, Lyons, Kathryn A., Nargund, Ravi P., Lin, Linus S.

“…Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein coupled receptor belonging to the subfamily of bombesin-like receptors. BRS-3 is implicated in the…”
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Imidazopyridyl compounds as aldosterone synthase inhibitors by Whitehead, Brent R., Lo, Michael M.-C., Ali, Amjad, Park, Min K., Hoyt, Scott B., Xiong, Yusheng, Cai, Jiaqiang, Carswell, Emma, Cooke, Andrew, MacLean, John, Ratcliffe, Paul, Robinson, John, Bennett, D. Jonathan, Clemas, Joseph A., Wisniewski, Tom, Struthers, Mary, Cully, Doris, MacNeil, Douglas J.

“…[Display omitted] The inhibition of aldosterone synthase (CYP11B2) may be an effective treatment of hypertension and heart failure, among other ailments…”
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Effect of 2,6-Disubstituted Aryl Groups on Acyclic Conformation:  Preference for an Antiperiplanar Orientation of the Geminal and Vicinal Hydrogens by Carlier, Paul R, Zhang, Yiqun, Slebodnick, Carla, Lo, Michael M.-C, Williams, Ian D

“…Multiple X-ray crystallographic and 1H NMR spectroscopic studies demonstrate that 2,6-disubstituted aryl groups exert a strong effect on acyclic conformation,…”
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Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids by Chen, Chuo, Li, Xiaodong, Neumann, Christopher S., Lo, Michael M.-C., Schreiber, Stuart L.

“…Complex small‐molecule libraries were constructed by a convergent approach with a short linear sequence: a 480‐membered bridged‐piperidine/fused‐pyrrolidine…”
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Cu(I)/Bis(azaferrocene)-Catalyzed Enantioselective Synthesis of β-Lactams via Couplings of Alkynes with Nitrones by Lo, Michael M.-C, Fu, Gregory C

“…As a consequence of the wide-ranging significance of β-lactams (e.g., use as drugs and as chiral building blocks), a great deal of effort has been dedicated to…”
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Synthesis and Application of Planar-Chiral Phosphaferrocene-Oxazolines, a New Class of P,N-Ligands by Shintani, Ryo, Lo, Michael M.-C, Fu, Gregory C

“…The synthesis of several phosphaferrocene-oxazolines, members of a new family of planar-chiral ligands, is described. These bidentate P,N-ligands are applied…”
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Enantioselective Isomerization of Allylic Alcohols Catalyzed by a Rhodium/Phosphaferrocene Complex by Tanaka, Ken, Qiao, Shuang, Tobisu, Mamoru, Lo, Michael M.-C, Fu, Gregory C

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1,2-Azaborolyls, Isoelectronic Analogues of the Ubiquitous Cyclopentadienyl Ligand: Synthesis of B-Heteroatom-Substituted 1,2-Azaborolyl Complexes and an Assessment of Their Electronic Features by Liu, Shih-Yuan, Lo, Michael M.-C., Fu, Gregory C.

“…The substituent on boron allows the electronic nature of the heterocycle of B‐heteroatom‐substituted (R=H, O, S, N, P, and F) 1,2‐azaborolyl complexes to be…”
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A New Class of Planar−Chiral Ligands:  Synthesis of a C 2-Symmetric Bisazaferrocene and Its Application in the Enantioselective Cu(I)-Catalyzed Cyclopropanation of Olefins by Lo, Michael M.-C, Fu, Gregory C

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The synthesis of an enantiopure planar-chiral Lewis acid complex via kinetic resolution and its application in stereoselective additions to imines by Liu, Shih-Yuan, Lo, Michael M.-C., Fu, Gregory C.

“…This report describes the synthesis and an application of a new planar-chiral Lewis acid based on a 1,2-azaborolyl framework. The enantiopure complex is…”
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Applications of planar-chiral heterocycles in enantioselective catalysis: Cu(I)/bisazaferrocene-catalyzed asymmetric ring expansion of oxetanes to tetrahydrofurans by Lo, Michael M.-C., Fu, Gregory C.

“…A planar-chiral, C 2-symmetric bisazaferrocene ligand is shown to control the stereochemistry of Cu(I)-catalyzed ring expansions of oxetanes to…”
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Planar-Chiral Pyridine N-Oxides, a New Family of Asymmetric Catalysts:  Exploiting an η5-C5Ar5 Ligand to Achieve High Enantioselectivity1 by Tao, Beata, Lo, Michael M.-C, Fu, Gregory C

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A New Class of Planar−Chiral Ligands:  Synthesis of a C2-Symmetric Bisazaferrocene and Its Application in the Enantioselective Cu(I)-Catalyzed Cyclopropanation of Olefins by LO, Michael M.-C., FU, Gregory C.

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Synthesis, Structure, and Reactivity of C 2-Symmetric Bis(phospholyl)zirconium and Bis(phospholyl)hafnium Complexes by Bellemin-Laponnaz, Stéphane, Lo, Michael M.-C, Peterson, Thomas H, Allen, Jerry M, Fu, Gregory C

“…Several C 2-symmetric bis(phospholyl) adducts of group 4 metals, including the first example of an η5-phospholyl complex of hafnium, have been synthesized and…”
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HMPA Promotes Retro-Aldol Reaction, Resulting in Syn-Selective Addition of Lithiated 1-Naphthylacetonitrile to Aromatic Aldehydes by Carlier, Paul R, Lo, Cedric W.-S, Lo, Michael M.-C, Wan, Nan Chi, Williams, Ian D

“…In HMPA−THF solution, lithiated 1-naphthylacetonitrile undergoes highly syn-selective addition to aromatic aldehydes, providing the first access to such…”
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Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids by Chen, Chuo, Li, Xiaodong, Neumann, Christopher S., Lo, Michael M.-C., Schreiber, Stuart L.

“…Komplexe Bibliotheken kleiner Moleküle wurden durch einen konvergenten Ansatz mit kurzer linearer Sequenz erhalten: die Hybridbibliothek IV und die…”
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1,2-Azaborolyls, Isoelectronic Analogues of the Ubiquitous Cyclopentadienyl Ligand: Synthesis of B-Heteroatom-Substituted 1,2-Azaborolyl Complexes and an Assessment of Their Electronic Features by Liu, Shih-Yuan, Lo, Michael M.-C., Fu, Gregory C.

“…Der Substituent am Bor ermöglicht die feine Abstimmung der elektronischen Natur des Heterocyclus in B‐Heteroatom‐substituierten 1,2‐Azaborolylkomplexen (R=H,…”
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