Search Results - "Lo, Kinyui Alice"

De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development by Alvarez-Dominguez, Juan R., Bai, Zhiqiang, Xu, Dan, Yuan, Bingbing, Lo, Kinyui Alice, Yoon, Myeong Jin, Lim, Yen Ching, Knoll, Marko, Slavov, Nikolai, Chen, Shuai, Chen, Peng, Lodish, Harvey F., Sun, Lei

“…Brown adipose tissue (BAT) protects against obesity by promoting energy expenditure via uncoupled respiration. To uncover BAT-specific long non-coding RNAs…”
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Analysis of In Vitro Insulin-Resistance Models and Their Physiological Relevance to In Vivo Diet-Induced Adipose Insulin Resistance by Lo, Kinyui Alice, Labadorf, Adam, Kennedy, Norman J., Han, Myoung Sook, Yap, Yoon Sing, Matthews, Bryan, Xin, Xiaofeng, Sun, Lei, Davis, Roger J., Lodish, Harvey F., Fraenkel, Ernest

“…Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced…”
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Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes by Lo, Kinyui Alice, Sun, Lei

“…Adipose tissue has a central role in the regulation of energy balance and homoeostasis. There are two main types of adipose tissue: WAT (white adipose tissue)…”
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Long noncoding RNAs regulate adipogenesis by Sun, Lei, Goff, Loyal A., Trapnell, Cole, Alexander, Ryan, Lo, Kinyui Alice, Hacisuleyman, Ezgi, Sauvageau, Martin, Tazon-Vega, Barbara, Kelley, David R., Hendrickson, David G., Yuan, Bingbing, Kellis, Manolis, Lodish, Harvey F., Rinn, John L.

“…The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes,…”
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De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis by Ding, Chunming, Lim, Yen Ching, Chia, Sook Yoong, Walet, Arcinas Camille Esther, Xu, Shaohai, Lo, Kinyui Alice, Zhao, Yanling, Zhu, Dewen, Shan, Zhihui, Chen, Qingfeng, Leow, Melvin Khee-Shing, Xu, Dan, Sun, Lei

“…Obesity has emerged as an alarming health crisis due to its association with metabolic risk factors such as diabetes, dyslipidemia, and hypertension. Recent…”
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Adipocyte Long Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-leptin Which Regulates Leptin by Lo, Kinyui Alice, Huang, Shiqi, Esther Walet, Arcinas Camille, Zhang, Zhi-Chun, Khee-Shing Leow, Melvin, Liu, Meihui, Sun, Lei

“…Obesity induces profound transcriptome changes in adipocytes; recent evidence suggests that lncRNAs play key roles in this process. Here, we performed a…”
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Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism by Liu, Qingqing, Yuan, Bingbing, Lo, Kinyui Alice, Patterson, Heide Christine, Sun, Yutong, Lodish, Harvey F

“…The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in…”
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Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators by Bai, Zhiqiang, Chai, Xiao-Ran, Yoon, Myeong Jin, Kim, Hye-Jin, Lo, Kinyui Alice, Zhang, Zhi-Chun, Xu, Dan, Siang, Diana Teh Chee, Walet, Arcinas Camille Esther, Xu, Shao-Hai, Chia, Sook-Yoong, Chen, Peng, Yang, Hongyuan, Ghosh, Sujoy, Sun, Lei

“…Enhancing brown fat activity and promoting white fat browning are attractive therapeutic strategies for treating obesity and associated metabolic disorders. To…”
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Differentiation of hypothalamic-like neurons from human pluripotent stem cells by Wang, Liheng, Meece, Kana, Williams, Damian J, Lo, Kinyui Alice, Zimmer, Matthew, Heinrich, Garrett, Martin Carli, Jayne, Leduc, Charles A, Sun, Lei, Zeltser, Lori M, Freeby, Matthew, Goland, Robin, Tsang, Stephen H, Wardlaw, Sharon L, Egli, Dieter, Leibel, Rudolph L

“…The hypothalamus is the central regulator of systemic energy homeostasis, and its dysfunction can result in extreme body weight alterations. Insights into the…”
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MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes by Kim, Hye-Jin, Cho, Hyunjii, Alexander, Ryan, Patterson, Heide Christine, Gu, Minxia, Lo, Kinyui Alice, Xu, Dan, Goh, Vera J, Nguyen, Long N, Chai, Xiaoran, Huang, Cher X, Kovalik, Jean-Paul, Ghosh, Sujoy, Trajkovski, Mirko, Silver, David L, Lodish, Harvey, Sun, Lei

“…Brown adipose tissue (BAT) is specialized to burn lipids for heat generation as a natural defense against cold and obesity. Previous studies established…”
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Genome-wide profiling of H3K56 acetylation and transcription factor binding sites in human adipocytes by Lo, Kinyui Alice, Bauchmann, Mary K, Baumann, Amy P, Donahue, Christopher J, Thiede, Mark A, Hayes, Lisa S, des Etages, Shelley Ann G, Fraenkel, Ernest

“…The growing epidemic of obesity and metabolic diseases calls for a better understanding of adipocyte biology. The regulation of transcription in adipocytes is…”
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De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development by Alvarez-Dominguez, Juan R., Bai, Zhiqiang, Xu, Dan, Yuan, Bingbing, Lo, Kinyui Alice, Yoon, Myeong Jin, Lim, Yen Ching, Knoll, Marko, Slavov, Nikolai, Chen, Shuai, Chen, Peng, Lodish, Harvey F., Sun, Lei

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Multisystem inflammatory syndrome in children (MIS-C) of a toddler initially presenting with fever and pyuria by Lo, Kinyui Alice, Goh, Lee Gan, Ramachandran, Rajeev

“…We report a case of multisystem inflammatory syndrome in children (MIS-C) in an East Asian toddler. He presented with a 2-day history of fever and pyuria, 5…”
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Wnt inhibition enhances browning of mouse primary white adipocytes by Lo, Kinyui Alice, Ng, Pei Yi, Kabiri, Zahra, Virshup, David, Sun, Lei

“…The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage…”
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De novo Reconstruction of Adipose Tissue Transcriptomes Reveals Novel Long Non-coding RNAs that Regulate Brown Adipocyte Development by Alvarez-Dominguez, Juan R., Bai, Zhiqiang, Xu, Dan, Yuan, Bingbing, Lo, Kinyui Alice, Yoon, Myeong Jin, Lim, Yen Ching, Knoll, Marko, Slavov, Nikolai, Chen, Shuai, Peng, Chen, Lodish, Harvey F., Sun, Lei

“…Brown adipose tissue (BAT) protects against obesity by promoting energy expenditure via uncoupled respiration. To uncover BAT-specific long non-coding RNAs…”
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Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat by Seiler, Sarah E, Xu, Dan, Ho, Jia-Pei, Lo, Kinyui Alice, Buehrer, Benjamin M, Ludlow, Y John W, Kovalik, Jean-Paul, Sun, Lei

“…Brown fat has gained widespread attention as a potential therapeutic target to treat obesity and associated metabolic disorders. Indeed, the anti-obesity…”
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Wnt inhibition enhances browning of mouse primary white adipocytes by Lo, Kinyui Alice, Ng, Pei Yi, Kabiri, Zahra, Virshup, David, Sun, Lei

“…The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage…”
Get full text

Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat by Seiler, Sarah E, Xu, Dan, Ho, Jia-Pei, Lo, Kinyui Alice, Buehrer, Benjamin M, Ludlow, Y John W, Kovalik, Jean-Paul, Sun, Lei

“…Brown fat has gained widespread attention as a potential therapeutic target to treat obesity and associated metabolic disorders. Indeed, the anti-obesity…”
Get full text