Search Results - "Lo, April"

Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer by Lo, April, McSharry, Maria, Berger, Alice H

“…Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic…”
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Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer by Vichas, Athea, Riley, Amanda K., Nkinsi, Naomi T., Kamlapurkar, Shriya, Parrish, Phoebe C. R., Lo, April, Duke, Fujiko, Chen, Jennifer, Fung, Iris, Watson, Jacqueline, Rees, Matthew, Gabel, Austin M., Thomas, James D., Bradley, Robert K., Lee, John K., Hatch, Emily M., Baine, Marina K., Rekhtman, Natasha, Ladanyi, Marc, Piccioni, Federica, Berger, Alice H.

“…CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common…”
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eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants by Thornton, Alexis M, Fang, Lishan, Lo, April, McSharry, Maria, Haan, David, O'Brien, Casey, Berger, Alice H, Giannakis, Marios, Brooks, Angela N

“…While advancements in genome sequencing have identified millions of somatic mutations in cancer, their functional impact is poorly understood. We previously…”
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Characterization of genetic subclonal evolution in pancreatic cancer mouse models by Niknafs, Noushin, Zhong, Yi, Moral, John Alec, Zhang, Lance, Shao, Melody Xiaoshan, Lo, April, Makohon-Moore, Alvin, Iacobuzio-Donahue, Christine A., Karchin, Rachel

“…The KPC mouse model, driven by the Kras and Trp53 transgenes, is well regarded for faithful recapitulation of human pancreatic cancer biology. However, the…”
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Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1 by Lo, April, Holmes, Kristin, Kamlapurkar, Shriya, Mundt, Filip, Moorthi, Sitapriya, Fung, Iris, Fereshetian, Shaunt, Watson, Jacqueline, Carr, Steven A, Mertins, Philipp, Berger, Alice H

“…Aberrant activation of the RAS family of guanosine triphosphatases (GTPases) is prevalent in lung adenocarcinoma, with somatic mutation of occurring in ~30% of…”
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Abstract 4345: A large-scale RNA-seq screen to identify regulators of alternative splicing in cancer by Lo, April, McSharry, Maria, Berger, Alice

“…Abstract RNA splicing is dysregulated in a widespread manner in cancers including lung adenocarcinoma. In some cases, splicing changes can be attributed to…”
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Impact of Sequence Uniqueness on MRD Monitoring in NGS Immunoglobulin Sequencing: An Analysis of Ig Loci Among >1200 Diffuse Large B-Cell Lymphoma Patients Tested By Clonoseq by Simmons, Heidi, Lee, Lik Wee, Lo, April, Akers, Kipp, Kirsch, Ilan M., Jacob, Allison P.

“…Introduction Diffuse Large B-Cell Lymphoma (DLBCL) is an aggressive form of non-Hodgkin lymphoma that most commonly affects older adults. While ~80% of…”
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Oncogene-Driven Post-Transcriptional Regulation in Lung Cancer by Lo, April

“…Lung cancer is often caused by genetic mutations which alter the activity of proteins in the RAS family, with somatic mutation of the KRAS gene occurring in…”
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Abstract 778: Dysregulation of alternative mRNA splicing by oncogenic KRAS in lung adenocarcinoma by Lo, April, McSharry, Maria, Berger, Alice H.

“…Abstract Alternative mRNA splicing is dysregulated in many cancers including lung adenocarcinoma. These aberrant splicing events can sometimes be explained by…”
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Massively parallel phenotyping of coding variants in cancer with Perturb-seq by Ursu, Oana, Neal, James T., Shea, Emily, Thakore, Pratiksha I., Jerby-Arnon, Livnat, Nguyen, Lan, Dionne, Danielle, Diaz, Celeste, Bauman, Julia, Mosaad, Mariam Mounir, Fagre, Christian, Lo, April, McSharry, Maria, Giacomelli, Andrew O., Ly, Seav Huong, Rozenblatt-Rosen, Orit, Hahn, William C., Aguirre, Andrew J., Berger, Alice H., Regev, Aviv, Boehm, Jesse S.

“…Genome sequencing studies have identified millions of somatic variants in cancer, but it remains challenging to predict the phenotypic impact of most…”
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Author Correction: Massively parallel phenotyping of coding variants in cancer with Perturb-seq by Ursu, Oana, Neal, James T., Shea, Emily, Thakore, Pratiksha I., Jerby-Arnon, Livnat, Nguyen, Lan, Dionne, Danielle, Diaz, Celeste, Bauman, Julia, Mosaad, Mariam Mounir, Fagre, Christian, Lo, April, McSharry, Maria, Giacomelli, Andrew O., Ly, Seav Huong, Rozenblatt-Rosen, Orit, Hahn, William C., Aguirre, Andrew J., Berger, Alice H., Regev, Aviv, Boehm, Jesse S.

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