Search Results - "Lo, Allen T. Y."
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Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli
Published in Nature communications (27-09-2024)“…Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader…”
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Escherichia coli Single-Stranded DNA-Binding Protein: NanoESI-MS Studies of Salt-Modulated Subunit Exchange and DNA Binding Transactions
Published in Journal of the American Society for Mass Spectrometry (01-02-2013)“…Single-stranded DNA-binding proteins (SSBs) are ubiquitous oligomeric proteins that bind with very high affinity to single-stranded DNA and have a variety of…”
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Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction
Published in Antibiotics (Basel) (22-02-2018)“…In bacteria, the DnaG primase is responsible for synthesis of short RNA primers used to initiate chain extension by replicative DNA polymerase(s) during…”
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A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome
Published in Molecular cell (02-07-2020)“…Recent studies of bacterial DNA replication have led to a picture of the replisome as an entity that freely exchanges DNA polymerases and displays intermittent…”
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