Antipostmenopausal effects of Stauntonia hexaphylla and Vaccinium bracteatum fruit combination in estrogen-deficient rats

Antipostmenopausal effects of Stauntonia hexaphylla and Vaccinium bracteatum fruit combination in estrogen-deficient rats

Climacterium is a series of physical and mental symptoms occurring in women and men due to decreased levels of sex hormones. Women lose the ability to become pregnant due to decreased ovarian estrogen production; the initial symptom being hot flushes. In addition, urogenital atrophy, sexual dysfunct...

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Bibliographic Details
Published in:Food & nutrition research Vol. 64; pp. 1 - 12
Main Authors: Lee, Gyuok, Shin, Jawon, Jo, Ara, Lm, Sojeong, Kim, Mi-Ri, Shoi, Yunhee, Yun, Hyojeong, Bae, Donghyuck, Kim, Jaeyong, Choi, Chul-Yung
Format: Journal Article
Language:English
Published: Sweden Open Academia 15-10-2020
Swedish Nutrition Foundation
Subjects:
estrogen
hot flushes
menopause
Original
osteoporosis
ovariectomy
hot flushes
estrogen
menopause
osteoporosis
ovariectomy
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Summary:Climacterium is a series of physical and mental symptoms occurring in women and men due to decreased levels of sex hormones. Women lose the ability to become pregnant due to decreased ovarian estrogen production; the initial symptom being hot flushes. In addition, urogenital atrophy, sexual dysfunction, mood changes, and osteoporosis occur. Extracts of (SH) and (VB) fruits, with a wide range of biological activities, are widely used in traditional herbal medicine. The purpose of this study was to investigate the mitigation of menopausal symptoms, such as hot flushes and postmenopausal osteoporosis after combinatorial treatment with SH and VB (SHVB) of ovariectomized (OVX) rats. We measured the bone regenerative effect of SHVB on receptor activator of nuclear factor-κB (NF-κB) ligand-induced osteoclast differentiation and on ovariectomy-induced osteoporosis . We investigated the effect of SHVB in a rat model of menopausal hot flushes, in which the tail skin temperature increases following ovariectomy-induced rapid decline in estrogen levels. SHVB inhibited osteoclast formation and tartrate-resistant acid phosphatase activity in primary mouse bone marrow-derived cells. In an estrogen deficiency-induced rat model, measurement of serum bone turnover factors showed that treatment with SHVB lowered the increased bone turnover. Additionally, SHVB decreased OVX-induced bone loss of the total femur. SHVB inhibited osteoclast differentiation, prevented bone mass reduction, and improved trabecular bone structure and biochemical markers in OVX-induced osteoporosis. In addition, administration of SHVB significantly ameliorated the changes in skin temperature in OVX rats. SHVB improved the symptoms of menopause. These results provide the foundation for developing SHVB as a natural substance to replace hormones in the future.
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ISSN:1654-661X
1654-661X
DOI:10.29219/fnr.v64.5233