Search Results - "Lloyd, Matthew G."

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays by Pierrat, Olivier A., Liu, Manjuan, Collie, Gavin W., Shetty, Kartika, Rodrigues, Matthew J., Le Bihan, Yann-Vaï, Gunnell, Emma A., McAndrew, P. Craig, Stubbs, Mark, Rowlands, Martin G., Yahya, Norhakim, Shehu, Erald, Talbot, Rachel, Pickard, Lisa, Bellenie, Benjamin R., Cheung, Kwai-Ming J., Drouin, Ludovic, Innocenti, Paolo, Woodward, Hannah, Davis, Owen A., Lloyd, Matthew G., Varela, Ana, Huckvale, Rosemary, Broccatelli, Fabio, Carter, Michael, Galiwango, David, Hayes, Angela, Raynaud, Florence I., Bryant, Christopher, Whittaker, Steven, Rossanese, Olivia W., Hoelder, Swen, Burke, Rosemary, van Montfort, Rob L. M.

“…By suppressing gene transcription through the recruitment of corepressor proteins, B-cell lymphoma 6 (BCL6) protein controls a transcriptional network required…”
Get full text

A Longitudinal Study of the Association of Clinical Indices of Cardiovascular Autonomic Function with Breast Cancer Treatment and Exercise Training by Kirkham, Amy A., Lloyd, Matthew G., Claydon, Victoria E., Gelmon, Karen A., McKenzie, Donald C., Campbell, Kristin L.

“…Background Cardiovascular autonomic dysfunction is an early marker for cardiovascular disease. Anthracycline chemotherapy and left‐sided radiation for breast…”
Get full text

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders by Bellenie, Benjamin R, Cheung, Kwai-Ming J, Varela, Ana, Pierrat, Olivier A, Collie, Gavin W, Box, Gary M, Bright, Michael D, Gowan, Sharon, Hayes, Angela, Rodrigues, Matthew J, Shetty, Kartika N, Carter, Michael, Davis, Owen A, Henley, Alan T, Innocenti, Paolo, Johnson, Louise D, Liu, Manjuan, de Klerk, Selby, Le Bihan, Yann-Vaï, Lloyd, Matthew G, McAndrew, P. Craig, Shehu, Erald, Talbot, Rachel, Woodward, Hannah L, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M, Raynaud, Florence I, Rossanese, Olivia W, Hoelder, Swen

“…Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target…”
Get full text

Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19 by Hira, Rashmin, Baker, Jacquie R., Siddiqui, Tanya, Ranada, Shaun I., Soroush, Ateyeh, Karalasingham, Kavithra, Ahmad, Hyeqa, Mavai, Vibhuti, Ayala Valani, Luciano Martin, Ambreen, Sakina, Bourne, Kate M., Lloyd, Matthew G., Morillo, Carlos A., Sheldon, Robert S., Raj, Satish R., Ahmad, Hyeqa, Ambreen, Sakina, Ayala Valani, Luciano M., Baker, Jacquie R., Bourne, Kate M., Dunn, Jeff F., Hira, Rashmin, Karalasingham, Kavithra, Lloyd, Matthew G., Mavai, Vibhuti, Morillo, Carlos A., Raj, Satish R., Ranada, Shaun I., Sheldon, Robert S., Siddiqui, Tanya, Soroush, Ateyeh, Guzman, Juan C., Claydon, Victoria, Ayala-Paredes, Felix A., Floras, John, Harvey, Paula, Osuntokun, Oluwatosin

“…Many COVID-19 patients are left with symptoms several months after resolution of the acute illness; this syndrome is known as post-acute sequalae of COVID-19…”
Get full text

Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors by Davis, Owen A., Cheung, Kwai-Ming J., Brennan, Alfie, Lloyd, Matthew G., Rodrigues, Matthew J., Pierrat, Olivier A., Collie, Gavin W., Le Bihan, Yann-Vaï, Huckvale, Rosemary, Harnden, Alice C., Varela, Ana, Bright, Michael D., Eve, Paul, Hayes, Angela, Henley, Alan T., Carter, Michael D., McAndrew, P. Craig, Talbot, Rachel, Burke, Rosemary, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Meniconi, Mirco, Bellenie, Benjamin R., Hoelder, Swen

“…To identify new chemical series with enhanced binding affinity to the BTB domain of B-cell lymphoma 6 protein, we targeted a subpocket adjacent to Val18. With…”
Get full text

Erratum to "Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19" [Can J Cardiol 39 (2023):767-775] by Hira, Rashmin, Baker, Jacquie R, Siddiqui, Tanya, Ranada, Shaun I, Soroush, Ateyeh, Karalasingham, Kavithra, Ahmad, Hyeqa, Mavai, Vibhuti, Valani, Luciano Martin Ayala, Ambreen, Sakina, Bourne, Kate M, Lloyd, Matthew G, Morillo, Carlos A, Sheldon, Robert S, Raj, Satish R

Get full text

Forearm vascular resistance responses to the Valsalva maneuver in healthy young and older adults by Hockin, Brooke C. D., Tang, Eileen Z., Lloyd, Matthew G., Claydon, Victoria E.

“…Purpose Effective end-organ peripheral vascular resistance responses are critical to blood pressure control while upright, and prevention of syncope…”
Get full text

Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket by Lloyd, Matthew G, Huckvale, Rosemary, Cheung, Kwai-Ming J, Rodrigues, Matthew J, Collie, Gavin W, Pierrat, Olivier A, Gatti Iou, Mahad, Carter, Michael, Davis, Owen A, McAndrew, P. Craig, Gunnell, Emma, Le Bihan, Yann-Vaï, Talbot, Rachel, Henley, Alan T, Johnson, Louise D, Hayes, Angela, Bright, Michael D, Raynaud, Florence I, Meniconi, Mirco, Burke, Rosemary, van Montfort, Rob L. M, Rossanese, Olivia W, Bellenie, Benjamin R, Hoelder, Swen

“…We describe the optimization of modestly active starting points to potent inhibitors of BCL6 by growing into a subpocket, which was occupied by a network of…”
Get full text

A One-Pot C–H Insertion/Olefination Sequence for the Formation of α‑Alkylidene-γ-butyrolactones by Lloyd, Matthew G, Taylor, Richard J. K, Unsworth, William P

“…A one-pot C–H insertion/olefination sequence for the conversion of α-diazo-α-(dialkoxy­phos­phoryl)­acetates into α-alkyli­dene-γ-butyro­lactones is reported…”
Get full text

A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products by Lloyd, Matthew G, D'Acunto, Mariantonietta, Taylor, Richard J K, Unsworth, William P

“…A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into…”
Get more information

Abnormal Valsalva: Not Always Due to Heart Failure by Lloyd, Matthew G., Raj, Satish R.

Get full text

Phosphorylated cyclopropanes in the synthesis of α-alkylidene-γ-butyrolactones: total synthesis of (±)-savinin, (±)-gadain and (±)-peperomin E by Lloyd, Matthew G, Taylor, Richard J K, Unsworth, William P

“…Phosphorylated cyclopropanes, generated via the Rh(ii)-catalysed intramolecular cyclopropanation of α-(diethoxyphosphoryl)acetates, have been found to be…”
Get more information

New indices from microneurography to investigate the arterial baroreflex by Laurin, Alexandre, Lloyd, Matthew G., Hachiya, Tesshin, Saito, Mitsuru, Claydon, Victoria E., Blaber, Andrew

“…Baroreflex‐mediated changes in heart rate and vascular resistance in response to variations in blood pressure are critical to maintain homeostasis. We aimed to…”
Get full text

Carotid sinus hypersensitivity: block of the sternocleidomastoid muscle does not affect responses to carotid sinus massage in healthy young adults by Lloyd, Matthew G., Wakeling, James M., Koehle, Michael S., Drapala, Robert J., Claydon, Victoria E.

“…The arterial baroreflex is crucial for short‐term blood pressure control – abnormal baroreflex function predisposes to syncope and falling. Hypersensitive…”
Get full text

α-Alkylidene-γ-butyrolactone synthesis via one-pot C–H insertion/olefination: substrate scope and the total synthesis of (±)-cedarmycins A and B by Lloyd, Matthew G., D'Acunto, Mariantonietta, Taylor, Richard J.K., Unsworth, William P.

“…A system for the synthesis of α-alkylidene-γ-butyrolactones via a one-pot C–H insertion/olefination sequence is described. The process is based on the rhodium…”
Get full text

Abnormal Valsalva by Lloyd, Matthew G., Raj, Satish R.

Get full text