Search Results - "Lloyd, Gavin R."

Partial least squares discriminant analysis: taking the magic away by Brereton, Richard G., Lloyd, Gavin R.

“…Partial least squares discriminant analysis (PLS‐DA) has been available for nearly 20 years yet is poorly understood by most users. By simple examples, it is…”
Get full text

Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics by Bowen, Tara J., Southam, Andrew D., Hall, Andrew R., Weber, Ralf J. M., Lloyd, Gavin R., Macdonald, Ruth, Wilson, Amanda, Pointon, Amy, Viant, Mark R.

“…Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the…”
Get full text

Partial least squares discriminant analysis for chemometrics and metabolomics: How scores, loadings, and weights differ according to two common algorithms by Brereton, Richard G., Lloyd, Gavin R.

“…Two common algorithms for partial least squares discriminant analysis developed by Wold (NIPALS) and by Martens are compared. Although their classification…”
Get full text

Re-evaluating the role of the Mahalanobis distance measure by Brereton, Richard G., Lloyd, Gavin R.

“…It is shown that the sum of squares of the standardised scores of all non‐zero principal components (PCs) equals the squared Mahalanobis distance. A new…”
Get full text

Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus by Barranco-Altirriba, Maria, Alonso, Núria, Weber, Ralf J M, Lloyd, Gavin R, Hernandez, Marta, Yanes, Oscar, Capellades, Jordi, Jankevics, Andris, Winder, Catherine, Falguera, Mireia, Franch-Nadal, Josep, Dunn, Warwick B, Perera-Lluna, Alexandre, Castelblanco, Esmeralda, Mauricio, Didac

“…In this study, we evaluated the lipidome alterations caused by type 1 diabetes (T1D) and type 2 diabetes (T2D), by determining lipids significantly associated…”
Get full text

The Lipidomic Profile Is Associated with the Dietary Pattern in Subjects with and without Diabetes Mellitus from a Mediterranean Area by Rojo-López, Marina Idalia, Barranco-Altirriba, Maria, Rossell, Joana, Antentas, Maria, Castelblanco, Esmeralda, Yanes, Oscar, Weber, Ralf J M, Lloyd, Gavin R, Winder, Catherine, Dunn, Warwick B, Julve, Josep, Granado-Casas, Minerva, Mauricio, Dídac

“…Lipid functions can be influenced by genetics, age, disease states, and lifestyle factors, particularly dietary patterns, which are crucial in diabetes…”
Get full text

Mirrored stainless steel substrate provides improved signal for Raman spectroscopy of tissue and cells by Lewis, Aaran T., Gaifulina, Riana, Isabelle, Martin, Dorney, Jennifer, Woods, Mae L., Lloyd, Gavin R., Lau, Katherine, Rodriguez‐Justo, Manuel, Kendall, Catherine, Stone, Nicholas, Thomas, Geraint M.

“…Raman spectroscopy (RS) is a powerful technique that permits the non‐destructive chemical analysis of cells and tissues without the need for expensive and…”
Get full text

Supervised Self Organizing Maps for Classification and Determination of Potentially Discriminatory Variables: Illustrated by Application to Nuclear Magnetic Resonance Metabolomic Profiling by Wongravee, Kanet, Lloyd, Gavin R, Silwood, Christopher J, Grootveld, Martin, Brereton, Richard G

“…The article describes the extension of the self organizing maps discrimination index (SOMDI) for cases where there are more than two classes and more than one…”
Get full text

Automated Sample Preparation and Data Collection Workflow for High-Throughput In Vitro Metabolomics by Malinowska, Julia M, Palosaari, Taina, Sund, Jukka, Carpi, Donatella, Lloyd, Gavin R, Weber, Ralf J M, Whelan, Maurice, Viant, Mark R

“…Regulatory bodies have started to recognise the value of in vitro screening and metabolomics as two types of new approach methodologies (NAMs) for chemical…”
Get full text

Infrared Spectroscopic Analysis in the Differentiation of Epithelial Misplacement From Adenocarcinoma in Sigmoid Colonic Adenomatous Polyps by Nallala, Jayakrupakar, Griggs, Rebecca, Lloyd, Gavin R, Stone, Nick, Shepherd, Neil A

“…Purpose: The differential diagnosis of epithelial misplacement from invasive cancer in the colon is a challenging endeavour, augmented by the introduction of…”
Get full text

An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues by Bowen, Tara J, Hall, Andrew R, Lloyd, Gavin R, Weber, Ralf J M, Wilson, Amanda, Pointon, Amy, Viant, Mark R

“…Discovering modes of action and predictive biomarkers of drug-induced structural cardiotoxicity offers the potential to improve cardiac safety assessment of…”
Get full text

Species-Specific Variations in the Metabolomic Profiles of Acropora hyacinthus and Acropora millepora Mask Acute Temperature Stress Effects in Adult Coral Colonies by Sweet, Michael, Bulling, Mark, Varshavi, Dorsa, Lloyd, Gavin R., Jankevics, Andris, Najdekr, Lukáš, Weber, Ralf J. M., Viant, Mark R., Craggs, Jamie

“…Coral reefs are suffering unprecedented declines in health state on a global scale. Some have suggested that human assisted evolution or assisted gene flow may…”
Get full text

Assessment of a custom-built Raman spectroscopic probe for diagnosis of early oesophageal neoplasia by Almond, L Max, Hutchings, Jo, Kendall, Catherine, Day, John C C, Stevens, Oliver A C, Lloyd, Gavin R, Shepherd, Neil A, Barr, Hugh, Stone, Nick

“…We evaluate the potential of a custom-built fiber-optic Raman probe, suitable for in vivo use, to differentiate between benign, metaplastic (Barrett's…”
Get full text

Suitability of Dried Blood Spots for Accelerating Veterinary Biobank Collections and Identifying Metabolomics Biomarkers With Minimal Resources by Allaway, David, Alexander, Janet E., Carvell-Miller, Laura J., Reynolds, Rhiannon M., Winder, Catherine L., Weber, Ralf J. M., Lloyd, Gavin R., Southam, Andrew D., Dunn, Warwick B.

“…Biomarker discovery using biobank samples collected from veterinary clinics would deliver insights into the diverse population of pets and accelerate…”
Get full text

Multi-Omics Analysis of Diabetic Heart Disease in the db/db Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene by Faulkner, Ashton, Dang, Zexu, Avolio, Elisa, Thomas, Anita C, Batstone, Thomas, Lloyd, Gavin R, Weber, Ralf Jm, Najdekr, Lukáš, Jankevics, Andris, Dunn, Warwick B, Spinetti, Gaia, Vecchione, Carmine, Puca, Annibale A, Madeddu, Paolo

“…Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the…”
Get full text

Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line by Malinowska, Julia M., Palosaari, Taina, Sund, Jukka, Carpi, Donatella, Weber, Ralf J. M., Lloyd, Gavin R., Whelan, Maurice, Viant, Mark R.

“…Amongst omics technologies, metabolomics should have particular value in regulatory toxicology as the measurement of the molecular phenotype is the closest to…”
Get full text

Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached by Wilcock, Daniel J., Badrock, Andrew P., Wong, Chun W., Owen, Rhys, Guerin, Melissa, Southam, Andrew D., Johnston, Hannah, Telfer, Brian A., Fullwood, Paul, Watson, Joanne, Ferguson, Harriet, Ferguson, Jennifer, Lloyd, Gavin R., Jankevics, Andris, Dunn, Warwick B., Wellbrock, Claudia, Lorigan, Paul, Ceol, Craig, Francavilla, Chiara, Smith, Michael P., Hurlstone, Adam F.L.

“…Dysregulated cellular metabolism is a cancer hallmark for which few druggable oncoprotein targets have been identified. Increased fatty acid (FA) acquisition…”
Get full text

Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes by Gruszczynska, Hanna, Barnett, Rosemary E., Lloyd, Gavin R., Weber, Ralf J. M., Lawson, Thomas N., Zhou, Jiarui, Sostare, Elena, Colbourne, John K., Viant, Mark R.

“…Grouping/read-across is widely used for predicting the toxicity of data-poor target substance(s) using data-rich source substance(s). While the chemical…”
Get full text

Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay by Sostare, Elena, Bowen, Tara J., Lawson, Thomas N., Freier, Anne, Li, Xiaojing, Lloyd, Gavin R., Najdekr, Lukáš, Jankevics, Andris, Smith, Thomas, Varshavi, Dorsa, Ludwig, Christian, Colbourne, John K., Weber, Ralf J. M., Crizer, David M., Auerbach, Scott S., Bucher, John R., Viant, Mark R.

“…Benchmark dose (BMD) modeling estimates the dose of a chemical that causes a perturbation from baseline. Transcriptional BMDs have been shown to be relatively…”
Get full text

Rapid identification of human muscle disease with fibre optic Raman spectroscopy by Alix, James J P, Plesia, Maria, Lloyd, Gavin R, Dudgeon, Alexander P, Kendall, Catherine A, Hewamadduma, Channa, Hadjivassiliou, Marios, McDermott, Christopher J, Gorman, Gráinne S, Taylor, Robert W, Shaw, Pamela J, Day, John C C

“…The diagnosis of muscle disorders ("myopathies") can be challenging and new biomarkers of disease are required to enhance clinical practice and research…”
Get more information