Physiological expression of pancreatic somatostatin receptors in 99mTc-HYNIC-TOC scintigraphy

Purpose To describe the frequency of head and/or pancreas uncinate process uptake of 99mTc-HYNIC-TOC, to study its nature, and analyze its diagnostic value. Materials and methods Retrospective evaluation of 47 consecutive 99mTc-HYNIC-TOC examinations was conducted. Head and/or pancreas uncinate proc...

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Published in:	Clinical & translational oncology Vol. 19; no. 7; pp. 915 - 920
Main Authors:	de la Cueva, L., Lloro, P., Sangrós, M. J., López Vélez, L., Navarro, P., Sarria, L., Álvarez, S., Abós, D.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-07-2017
Subjects:	Adult Aged Aged, 80 and over Brief Research Article Female Follow-Up Studies Humans Male Medicine Medicine & Public Health Middle Aged Neuroendocrine Tumors - diagnostic imaging Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Octreotide - analogs & derivatives Octreotide - metabolism Oncology Organotechnetium Compounds - metabolism Pancreas - diagnostic imaging Pancreas - metabolism Pancreas - pathology Prognosis Radionuclide Imaging - methods Receptors, Somatostatin - metabolism Retrospective Studies Tomography, X-Ray Computed Somatostatin receptor scintigraphy 99mTc-HYNIC-TOC Pancreas uncinate process Neuroendocrine tumors
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Summary:	Purpose To describe the frequency of head and/or pancreas uncinate process uptake of 99mTc-HYNIC-TOC, to study its nature, and analyze its diagnostic value. Materials and methods Retrospective evaluation of 47 consecutive 99mTc-HYNIC-TOC examinations was conducted. Head and/or pancreas uncinate process uptake was considered to be physiological in patients with normal CT at the same episode and in follow-up. It was analyzed if age or diabetes mellitus was justifying the existence or not of uptake. Results 32.5% patients showed uptake; 73% of them were mild. 84.6% patients with uptake have no pathology and 4% had neuroendocrine pancreatic disease at CT. Neither the age nor the diabetes mellitus established differences in patients without lesion. Conclusions Near one-third of patients show physiological uptake by head and/or pancreas uncinate process at 99mTc-HYNIC-TOC scintigraphy. It seems that neither the diabetes nor the ages are factors that determine this physiological uptake.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1699-048X 1699-3055
DOI:	10.1007/s12094-017-1616-3