Search Results - "Llorente, Sergio Ruiz"

CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines by Garcia-Carpizo, Veronica, Ruiz-Llorente, Sergio, Sarmentero, Jacinto, González-Corpas, Ana, Barrero, Maria J

“…Inhibitors that prevent the binding of bromodomains to acetylated histones hold therapeutic potential. However, the effects of targeting most of the 60…”
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NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation by García-Carpizo, Verónica, Sarmentero, Jacinto, Han, Bomie, Graña, Osvaldo, Ruiz-Llorente, Sergio, Pisano, David G., Serrano, Manuel, Brooks, Harold B., Campbell, Robert M., Barrero, Maria J.

“…The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well…”
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CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation by Garcia-Carpizo, Veronica, Ruiz-Llorente, Sergio, Sarmentero, Jacinto, Graña-Castro, Osvaldo, Pisano, David G, Barrero, Maria J

“…The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the…”
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Randomized phase II clinical trial of ruxolitinib plus simvastatin in COVID19 clinical outcome and cytokine evolution by Garcia-Donas, Jesus, Martínez-Urbistondo, Diego, Velázquez Kennedy, Kyra, Villares, Paula, Barquin, Arántzazu, Dominguez, Andrea, Rodriguez-Moreno, Juan Francisco, Caro, Elena, Suarez Del Villar, Rafael, Nistal-Villan, Estanislao, Yagüe, Monica, Ortiz, Maria, Barba, Maria, Ruiz-Llorente, Sergio, Quiralte, Miguel, Zanin, Massimiliano, Rodríguez, Cristina, Navarro, Paloma, Berraondo, Pedro, Madurga, Rodrigo

“…Managing the inflammatory response to SARS-Cov-2 could prevent respiratory insufficiency. Cytokine profiles could identify cases at risk of severe disease. We…”
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Genetic characterization and structural analysis of VHL Spanish families to define genotype-phenotype correlations by Ruiz-Llorente, Sergio, Bravo, Jerónimo, Cebrián, Arancha, Cascón, Alberto, Pollan, Marina, Tellería, Dolores, Letón, Rocío, Urioste, Miguel, Rodríguez-López, Raquel, de Campos, Jose M., Muñoz, María J., Lacambra, Carmen, Benítez, Javier, Robledo, Mercedes

“…Von Hippel‐Lindau (VHL) disease is a hereditary cancer syndrome caused by germline mutations in the VHL gene. This gene, located in the 3p25‐26 chromosome, is…”
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A Resampling Univariate Analysis Approach to Ovarian Cancer From Clinical and Genetic Data by Bote-Curiel, Luis, Ruiz-Llorente, Sergio, Munoz-Romero, Sergio, Yague-Fernandez, Monica, Barquin, Arantzazu, Garcia-Donas, Jesus, Rojo-Alvarez, Jose Luis

“…Ovarian cancer (OC) is the second most common gynecological malignancy and the gynecological tumor with the worst prognosis. To try to improve this situation,…”
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Text Analytics and Mixed Feature Extraction in Ovarian Cancer Clinical and Genetic Data by Bote-Curiel, Luis, Ruiz-Llorente, Sergio, Munoz-Romero, Sergio, Yague-Fernandez, Monica, Barquin, Arantzazu, Garcia-Donas, Jesus, Rojo-Alvarez, Jose Luis

“…Developments of richer integrative analysis methods for oncological studies are needed for efficiently leveraging the amount of clinical and genetic data…”
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Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers by Montero‐Conde, Cristina, Leandro‐García, Luis Javier, Martínez‐Montes, Ángel M., Martínez, Paula, Moya, Francisco J., Letón, Rocío, Gil, Eduardo, Martínez‐Puente, Natalia, Guadalix, Sonsoles, Currás‐Freixes, Maria, García‐Tobar, Laura, Zafon, Carles, Jordà, Mireia, Riesco‐Eizaguirre, Garcilaso, González‐García, Patricia, Monteagudo, María, Torres‐Pérez, Rafael, Mancikova, Veronika, Ruiz‐Llorente, Sergio, Pérez‐Martínez, Manuel, Pita, Guillermo, Galofré, Juan Carlos, Gonzalez‐Neira, Anna, Cascón, Alberto, Rodríguez‐Antona, Cristina, Megías, Diego, Blasco, María A., Caleiras, Eduardo, Rodríguez‐Perales, Sandra, Robledo, Mercedes

“…Background Comprehensive molecular studies on tumours are needed to delineate immortalization process steps and identify sensitive prognostic biomarkers in…”
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Genome-wide analysis of Pax8 binding provides new insights into thyroid functions by Ruiz-Llorente, Sergio, Carrillo Santa de Pau, Enrique, Sastre-Perona, Ana, Montero-Conde, Cristina, Gómez-López, Gonzalo, Fagin, James A, Valencia, Alfonso, Pisano, David G, Santisteban, Pilar

“…The transcription factor Pax8 is essential for the differentiation of thyroid cells. However, there are few data on genes transcriptionally regulated by Pax8…”
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763 Expanded and activated TILs kill tumor cells enabling IO compound assays by Pennacchi, Paula Comune, Navarro, Paloma, Navas, Verónica García, García, Arántzazu Barquín, Fernández, Elena Sevillano, Llorente, Sergio Ruiz, Rodriguez, Juan Francisco, Yagüe, Monica, Ballesteros, Joan, Primo, Daniel, Donas Jimenez, Jesus Garcia

“…BackgroundThe Tumor Microenvironment (TME) has a key role in solid tumor therapy screening. We have developed a 3D ex vivo immunosuppressive assay mimicking…”
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An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility by Landa, Iñigo, Boullosa, Cesar, Inglada-Pérez, Lucía, Sastre-Perona, Ana, Pastor, Susana, Velázquez, Antonia, Mancikova, Veronika, Ruiz-Llorente, Sergio, Schiavi, Francesca, Marcos, Ricard, Malats, Nuria, Opocher, Giuseppe, Diaz-Uriarte, Ramon, Santisteban, Pilar, Valencia, Alfonso, Robledo, Mercedes

“…Papillary Thyroid Cancer (PTC) is a heterogeneous and complex disease; susceptibility to PTC is influenced by the joint effects of multiple common,…”
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Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: A possible hot spot? by Cascón, Alberto, Montero-Conde, Cristina, Ruiz-Llorente, Sergio, Mercadillo, Fátima, Letón, Rocío, Rodríguez-Antona, Cristina, Martínez-Delgado, Beatriz, Delgado, Manuel, Díez, Alberto, Rovira, Adela, Díaz, José Ángel, Robledo, Mercedes

“…Pheochromocytoma and paraganglioma are rare neuroendocrine tumors that arise in the adrenal medulla and the extra‐adrenal paraganglia, respectively…”
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Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients by Cascón, Alberto, Escobar, Beatriz, Montero-Conde, Cristina, Rodríguez-Antona, Cristina, Ruiz-Llorente, Sergio, Osorio, Ana, Mercadillo, Fátima, Letón, Rocío, Campos, José M., García-Sagredo, José M., Benítez, Javier, Malumbres, Marcos, Robledo, Mercedes

“…Clear cell renal cell carcinoma (ccRCC) is the most common malignant neoplasm of the kidney. The majority of hereditary and sporadic ccRCC cases are associated…”
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A novel candidate region linked to development of both pheochromocytoma and head/neck paraganglioma by Cascón, Alberto, Ruiz-Llorente, Sergio, Rodríguez-Perales, Sandra, Honrado, Emiliano, Martínez-Ramírez, Ángel, Letón, Rocío, Montero-Conde, Cristina, Benítez, Javier, Dopazo, Joaquín, Cigudosa, Juan C., Robledo, Mercedes

“…Although the histologic distinction between pheochromocytomas and head and neck paragangliomas is clear, little is known about the genetic differences between…”
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G12S and H50R variations are polymorphisms in the SDHD gene by Cascón, Alberto, Ruiz-Llorente, Sergio, Cebrián, Arancha, Letón, Rocío, Tellería, Dolores, Benítez, Javier, Robledo, Mercedes

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Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas by Montero-Conde, Cristina, Ruiz-Llorente, Sergio, Dominguez, Jose M, Knauf, Jeffrey A, Viale, Agnes, Sherman, Eric J, Ryder, Mabel, Ghossein, Ronald A, Rosen, Neal, Fagin, James A

“…The RAF inhibitor vemurafenib (PLX4032) increases survival in patients with BRAF-mutant metastatic melanoma, but has limited efficacy in patients with…”
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Proteomic profiling of peritoneal fluid-derived exosomes as a tool for the identification of prognostic markers in advanced ovarian carcinomas by Quiralte, Miguel, Barquin, Arantzazu, Yagüe, Monica, Navarro, Paloma, Sevillano, Elena, Rodriguez-Moreno, Juan Francisco, Balarezo, Alejandra, Peinado, Héctor, Izquierdo, Elena, Millan, Carlos, Lopez, Irene, Ruiz-Llorente, Sergio, García-Donas, Jesús

“…e17561 Background: Exosomes have been involved in tumor progression and development of therapeutic resistances in several malignancies. This subtype of…”
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Multivariate feature selection and autoencoder embeddings of ovarian cancer clinical and genetic data by Bote-Curiel, Luis, Ruiz-Llorente, Sergio, Muñoz-Romero, Sergio, Yagüe-Fernández, Mónica, Barquín, Arantzazu, García-Donas, Jesús, Rojo-Álvarez, José Luis

“…Although certain genetic alterations have been defined as predictive and prognostic biomarkers in the context of ovarian cancer (OC), data science methods…”
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Proteomic profiles of peritoneal fluid-derived small extracellular vesicles correlate with patient outcome in ovarian cancer by Quiralte, Miguel, Barquín, Arantzazu, Yagüe-Fernández, Mónica, Navarro, Paloma, Grazioso, Tatiana P, Sevillano-Fernández, Elena, Rodriguez-Moreno, Juan F, Balarezo-Saldivar, Alejandra, Peinado, Héctor, Izquierdo, Elena, Millán, Carlos, López-Carrasco, Irene, Prieto, Mario, Madurga, Rodrigo, Fernández-Miranda, Ismael, Ruiz-Llorente, Sergio, García-Donas, Jesús

“…Cancer-derived small extracellular vesicles (sEVs) are capable of modifying the tumor microenvironment and promoting tumor progression. Ovarian cancer (OvCa)…”
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Comprehensive molecular characterization of muscle-invasive bladder cancer (MIBC) treated with durvalumab plus olaparib in the neoadjuvant setting: Neodurvarib trial by Rodriguez-Moreno, Juan Francisco, Ruiz-Llorente, Sergio, De Velasco, Guillermo, Alvarez-Fernandez, Carlos, Collado Martín, Ricardo, Fernandez, Ricardo, Vazquez-Estevez, Sergio, Virizuela, Juan Antonio, Gajate, Pablo, Font, Albert, Lainez, Nuria, Barquin, Arantzazu, Beltran, Luis, Rodriguez-Antona, Cristina, Berraondo, Pedro, García-Donas, Jesús

“…Abstract only 546 Background: Immune checkpoint inhibitors have been incorporated to early-stage bladder carcinoma treatment recently. Durvalumab is a PD-L1…”
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