Search Results - "Lleres, David"

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex by Baird, Liam, Llères, David, Swift, Sam, Dinkova-Kostova, Albena T.

“…The transcription factor NF-E2 p45-related factor 2 (Nrf2), a master regulator of cytoprotective genes, is controlled by dimeric Kelch-like ECH associated…”
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Monitoring Keap1–Nrf2 interactions in single live cells by Baird, Liam, Swift, Sam, Llères, David, Dinkova-Kostova, Albena T.

“…The transcription factor NF-E2 p45-related factor 2 (Nrf2) and its negative regulator Kelch-like ECH associated protein 1 (Keap1) control the expression of…”
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Exploring chromatin structural roles of non-coding RNAs at imprinted domains by Llères, David, Imaizumi, Yui, Feil, Robert

“…Different classes of non-coding RNA (ncRNA) influence the organization of chromatin. Imprinted gene domains constitute a paradigm for exploring functional long…”
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CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains by Llères, David, Moindrot, Benoît, Pathak, Rakesh, Piras, Vincent, Matelot, Mélody, Pignard, Benoît, Marchand, Alice, Poncelet, Mallory, Perrin, Aurélien, Tellier, Virgile, Feil, Robert, Noordermeer, Daan

“…Genomic imprinting is essential for mammalian development and provides a unique paradigm to explore intra-cellular differences in chromatin configuration. So…”
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Evidence for low nanocompaction of heterochromatin in living embryonic stem cells by Dupont, Claire, Chahar, Dhanvantri, Trullo, Antonio, Gostan, Thierry, Surcis, Caroline, Grimaud, Charlotte, Fisher, Daniel, Feil, Robert, Llères, David

“…Despite advances in the identification of chromatin regulators and genome interactions, the principles of higher‐order chromatin structure have remained…”
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Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing by Shoaib, Muhammad, Walter, David, Gillespie, Peter J., Izard, Fanny, Fahrenkrog, Birthe, Lleres, David, Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, Klaus, Julien, Eric, Blow, J. Julian, Sørensen, Claus S.

“…The decompaction and re-establishment of chromatin organization immediately after mitosis is essential for genome regulation. Mechanisms underlying chromatin…”
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Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis by Sanli, Ildem, Lalevée, Sébastien, Cammisa, Marco, Perrin, Aurélien, Rage, Florence, Llères, David, Riccio, Andrea, Bertrand, Edouard, Feil, Robert

“…Although many long non-coding RNAs (lncRNAs) are imprinted, their roles often remain unknown. The Dlk1-Dio3 domain expresses the lncRNA Meg3 and multiple…”
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Quantitative analysis of chromatin compaction in living cells using FLIM-FRET by Llères, David, James, John, Swift, Sam, Norman, David G, Lamond, Angus I

“…We present a quantitative Förster resonance energy transfer (FRET)-based assay using multiphoton fluorescence lifetime imaging microscopy (FLIM) to measure…”
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ICR Noncoding RNA Expression Controls Imprinting and DNA Replication at the Dlk1-Dio3 Domain by Kota, Satya K., Llères, David, Bouschet, Tristan, Hirasawa, Ryutaro, Marchand, Alice, Begon-Pescia, Christina, Sanli, Ildem, Arnaud, Philippe, Journot, Laurent, Girardot, Michael, Feil, Robert

“…Imprinted genes play essential roles in development, and their allelic expression is mediated by imprinting control regions (ICRs). The Dlk1-Dio3 locus is…”
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Modulation of Higher Order Chromatin Conformation in Mammalian Cell Nuclei Can Be Mediated by Polyamines and Divalent Cations by Visvanathan, Ashwat, Ahmed, Kashif, Even-Faitelson, Liron, Lleres, David, Bazett-Jones, David P, Lamond, Angus I

“…The organisation of the large volume of mammalian genomic DNA within cell nuclei requires mechanisms to regulate chromatin compaction involving the reversible…”
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Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes by Llères, David, Bailly, Aymeric P., Perrin, Aurélien, Norman, David G., Xirodimas, Dimitris P., Feil, Robert

“…How metazoan genomes are structured at the nanoscale in living cells and tissues remains unknown. Here, we adapted a quantitative FRET (Förster resonance…”
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The 20S proteasome activator PA28γ controls the compaction of chromatin by Fesquet, Didier, Llères, David, Grimaud, Charlotte, Viganò, Cristina, Méchali, Francisca, Boulon, Séverine, Coux, Olivier, Bonne-Andrea, Catherine, Baldin, Véronique

“…PA28γ (also known as PSME3), a nuclear activator of the 20S proteasome, is involved in the degradation of several proteins regulating cell growth and…”
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Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice by Llères, David, Denegri, Marco, Biggiogera, Marco, Ajuh, Paul, Lamond, Angus I

“…Heterogeneous nuclear ribonucleoprotein‐M (hnRNP‐M) is an abundant nuclear protein that binds to pre‐mRNA and is a component of the spliceosome complex. A…”
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Epigenetic deregulation of genomic imprinting in humans: causal mechanisms and clinical implications by Girardot, Michael, Feil, Robert, Llères, David

“…Mammalian genes controlled by genomic imprinting play important roles in development and diverse postnatal processes. A growing number of congenital disorders…”
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Spatial mapping of splicing factor complexes involved in exon and intron definition by Ellis, Jonathan D, Llères, David, Denegri, Marco, Lamond, Angus I, Cáceres, Javier F

“…We have analyzed the interaction between serine/arginine-rich (SR) proteins and splicing components that recognize either the 5' or 3' splice site. Previously,…”
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Perturbation of chromatin structure globally affects localization and recruitment of splicing factors by Schor, Ignacio E, Llères, David, Risso, Guillermo J, Pawellek, Andrea, Ule, Jernej, Lamond, Angus I, Kornblihtt, Alberto R

“…Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing…”
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A Role for Caenorhabditis elegans COMPASS in Germline Chromatin Organization by Herbette, Marion, Robert, Valérie, Bailly, Aymeric, Gely, Loïc, Feil, Robert, Llères, David, Palladino, Francesca

“…Deposition of histone H3 lysine 4 (H3K4) methylation at promoters is catalyzed by the SET1/COMPASS complex and is associated with context-dependent effects on…”
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Quantitative Kinetic Analysis of Nucleolar Breakdown and Reassembly during Mitosis in Live Human Cells by Anthony Kar Lun Leung, Gerlich, Daniel, Miller, Gail, Lyon, Carol, Lam, Yun Wah, Lleres, David, Daigle, Nathalie, Zomerdijk, Joost, Ellenberg, Jan, Lamond, Angus I.

“…One of the great mysteries of the nucleolus surrounds its disappearance during mitosis and subsequent reassembly at late mitosis. Here, the relative dynamics…”
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The cell proliferation antigen Ki-67 organises heterochromatin by Sobecki, Michal, Mrouj, Karim, Camasses, Alain, Parisis, Nikolaos, Nicolas, Emilien, Llères, David, Gerbe, François, Prieto, Susana, Krasinska, Liliana, David, Alexandre, Eguren, Manuel, Birling, Marie-Christine, Urbach, Serge, Hem, Sonia, Déjardin, Jérôme, Malumbres, Marcos, Jay, Philippe, Dulic, Vjekoslav, Lafontaine, Denis Lj, Feil, Robert, Fisher, Daniel

“…Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear…”
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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients by Quinti, Luisa, Naidu, Sharadha Dayalan, Träger, Ulrike, Chen, Xiqun, Kegel-Gleason, Kimberly, Llères, David, Connolly, Colúm, Chopra, Vanita, Low, Cho, Moniot, Sébastien, Sapp, Ellen, Tousley, Adelaide R., Vodicka, Petr, Van Kanegan, Michael J., Kaltenbach, Linda S., Crawford, Lisa A., Fuszard, Matthew, Higgins, Maureen, Miller, James R. C., Farmer, Ruth E., Potluri, Vijay, Samajdar, Susanta, Meisel, Lisa, Zhang, Ningzhe, Snyder, Andrew, Stein, Ross, Hersch, Steven M., Ellerby, Lisa M., Weerapana, Eranthie, Schwarzschild, Michael A., Steegborn, Clemens, Leavitt, Blair R., Degterev, Alexei, Tabrizi, Sarah J., Lo, Donald C., DiFiglia, Marian, Thompson, Leslie M., Dinkova-Kostova, Albena T., Kazantsev, Aleksey G.

“…The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of…”
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