Search Results - "Lleonart, M"

Insights into new mechanisms and models of cancer stem cell multidrug resistance by Garcia-Mayea, Y., Mir, C., Masson, F., Paciucci, R., LLeonart, M.E.

“…The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment promote cancer progression, metastasis and therapy resistance. These…”
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p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors by Romagosa, C, Simonetti, S, López-Vicente, L, Mazo, A, Lleonart, M E, Castellvi, J, Ramon y Cajal, S

“…p16 Ink4a is a protein involved in regulation of the cell cycle. Currently, p16 Ink4a is considered a tumor suppressor protein because of its physiological…”
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Targeting the “undruggable”: RNA-binding proteins in the spotlight in cancer therapy by Mir, C., Garcia-Mayea, Y., LLeonart, M.E.

“…Tumors refractory to conventional therapy belong to specific subpopulations of cancer cells, which have acquired a higher number of mutations/epigenetic…”
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A new generation of proto-oncogenes: Cold-inducible RNA binding proteins by LLeonart, M.E.

“…This review focuses on the roles of two major cold-inducible RNA binding proteins known in human cells: CIRP and RBM3. Both proteins were discovered when they…”
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The cancer stem-cell signaling network and resistance to therapy by Carnero, A, Garcia-Mayea, Y, Mir, C, Lorente, J, Rubio, I.T, LLeonart, M.E

“…Graphical abstract…”
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p16 overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors by Romagosa, C, Simonetti, S, López-Vicente, L, Mazo, A, Lleonart, M E, Castellvi, J, Ramon y Cajal, S

“…p16(Ink4a) is a protein involved in regulation of the cell cycle. Currently, p16(Ink4a) is considered a tumor suppressor protein because of its physiological…”
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Ribosomal proteins as novel players in tumorigenesis by de las Heras-Rubio, A., Perucho, L., Paciucci, R., Vilardell, J., LLeonart, M. E.

“…Ribosome biogenesis is the most demanding energetic and metabolic expenditure of the cell. The nucleolus, a nuclear compartment, coordinates rRNA…”
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MicroRNAs and cancer stem cells: Therapeutic approaches and future perspectives by Leal, J.A, Lleonart, M.E

“…Abstract Cancer stem cells (CSCs) are a sub-population of cancer cells that possess characteristics associated with normal stem cells but with the peculiarity…”
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Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21 by Borgdorff, V, Lleonart, M E, Bishop, C L, Fessart, D, Bergin, A H, Overhoff, M G, Beach, D H

“…Overexpression of Ras(G12V) in primary cells induces a permanent growth arrest called oncogene-induced senescence (OIS) that serves as a fail-safe mechanism…”
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Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization by Kondoh, H, Lleonart, M E, Bernard, D, Gil, J

“…Reactive oxygen species (ROS) play a crucial role not only in the physiological signal transduction but also in the pathogenesis of several human diseases such…”
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S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis by Leal, J.F., Ferrer, I., Blanco-Aparicio, C., Hernández-Losa, J., Ramón y Cajal, S., Carnero, A., LLeonart, M.E.

“…With the idea to discover novel genes involved in proliferation, we have performed a genome-wide loss-of-function genetic screen to identify additional…”
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RNA-binding proteins: Underestimated contributors in tumorigenesis by Zhao, Y., Mir, C., Garcia-Mayea, Y., Paciucci, R., Kondoh, H., LLeonart, M.E.

“…mRNA export, translation, splicing, cleavage or capping determine mRNA stability, which represents one of the primary aspects regulating gene expression and…”
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New p53 related genes in human tumors : significant downregulation in colon and lung carcinomas by LLEONART, M. E, VIDAL, F, RAMON Y CAJAL, S, GALLARDO, D, DIAZ-FUERTES, M, ROJO, F, CUATRECASAS, M, LOPEZ-VICENTE, L, KONDOH, H, BLANCO, C, CARNERO, A

“…Human epithelial tumors need to accumulate multiple genetic alterations to form invasive carcinomas. These genetic alterations are related with growth factor…”
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Clinical and therapeutic profile and quality of life of patients with seborrheic dermatitis by Peyrí, J, Lleonart, M

“…The clinical characteristics of seborrheic dermatitis (SD), therapeutic strategies employed in current clinical practice and impact on the quality of life in…”
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Spionid mudworm infestation of farmed abalone ( Haliotis spp.) by Lleonart, M., Handlinger, J., Powell, M.

“…Severe spionid infestations of farmed abalone ( Haliotis spp.) were reported from several sea-based culture facilities during 1995–1997. Shell blister coverage…”
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Rplp1 bypasses replicative senescence and contributes to transformation by Artero-Castro, A., Kondoh, H., Fernández-Marcos, P.J., Serrano, M., y Cajal, S. Ramón, LLeonart, M.E.

“…To determine whether genes expressed by embryonic stem cells have a proliferative effect in primary cells, primary mouse embryonic fibroblasts were infected…”
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Cellular senescence bypass screen identifies new putative tumor suppressor genes by Leal, J F M, Fominaya, J, Cascón, A, Guijarro, M V, Blanco-Aparicio, C, Lleonart, M, Castro, M E, Ramon y Cajal, S, Robledo, M, Beach, D H, Carnero, A

“…Senescence is a mechanism that limits cellular lifespan and constitutes a barrier against cellular immortalization. To identify new senescence regulatory genes…”
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MAP17 enhances the malignant behavior of tumor cells through ROS increase by Guijarro, Maria V., Leal, Juan F.M., Blanco-Aparicio, Carmen, Alonso, Soledad, Fominaya, Jesús, Lleonart, Matilde, Castellvi, Josep, Ramon y Cajal, Santiago, Carnero, Amancio

“…Tumorigenesis occurs when the mechanisms involved in the control of tissue homeostasis are disrupted and cells stop responding to physiological signals…”
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Adenovirus E1A orchestrates the urokinase-plasminogen activator system and upregulates PAI-2 expression, supporting a tumor suppressor effect by FERNANDEZ-SORIA, V, LLEONART, M. E, DIAZ-FUERTES, M, VILLUENDAS, R, SANCHEZ-PRIETO, R, FABRA, A, CAJAL, S. Ramon Y

“…Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a…”
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Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1 by Borgdorff, V, Lleonart, M E, Bishop, C L, Fessart, D, Bergin, A H, Overhoff, M G, Beach, D H

“…Overexpression of Ras G12V in primary cells induces a permanent growth arrest called oncogene-induced senescence (OIS) that serves as a fail-safe mechanism…”
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