Effects of exercise on irisin in subjects with overweight or obesity. A systematic review of clinical studies

Irisin is an adipomyokine involved in white adipose tissue browning, therefore, could be a key protein in metabolic health. However, exercise effects on irisin in subjects with overweight and/or obesity are conflicting. Therefore, this systematic review aims to search and analyse the literature avai...

Full description

Saved in:

Bibliographic Details
Published in:	Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 39; no. 6; pp. 1389 - 1396
Main Authors:	Bernal Rivas, Camila, Llamunao Tropa, Ángela, Reyes Barría, Andrés, Halabi, Diego, Pavicic, Francisca, Ehrenfeld, Pamela, Martínez Huenchullán, Sergio
Format:	Journal Article
Language:	English
Published:	Spain Grupo Arán 20-12-2022
Subjects:	Exercise - physiology Exercise Therapy Fibronectins Humans Muscle, Skeletal - metabolism Nutrition & Dietetics Obesity - therapy Overweight - metabolism Ejercicio. Proteína 5 que contiene el dominio de fibronectina tipo III. FNDC5. Sobrepeso. Obesidad FNDC5 Obesity Ejercicio Obesidad Exercise Proteína 5 que contiene el dominio de fibronectina tipo III Sobrepeso Fibronectin type III domain-containing protein 5 Overweight
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Irisin is an adipomyokine involved in white adipose tissue browning, therefore, could be a key protein in metabolic health. However, exercise effects on irisin in subjects with overweight and/or obesity are conflicting. Therefore, this systematic review aims to search and analyse the literature available on this topic. From three databases: PubMed, ScienceDirect, and Medline, clinical studies published between 2010 and 2021 were considered. From 134 found, 14 studies were included. Only six reported plasma increases after exercise (~1.2 to 3-fold from pre-exercise levels). In addition, only 1 reported significant increases in skeletal muscle irisin mRNA levels (~2-fold). Also, irisin was measured from subcutaneous adipose tissue and saliva, where a ~2-fold increase in its protein levels was found in the latter. Exercise seems to increase the circulatory concentrations of irisin in subjects with overweight or obesity. However, this response is highly variable, therefore, a more integrative approach is urgently needed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0212-1611 1699-5198 1699-5198
DOI:	10.20960/nh.04202