Liposomal formulation of a gold(III) metalloantibiotic: a promising strategy against antimicrobial resistance

A novel lipoformulation was developed by encapsulating cationic (S^C)-cyclometallated gold(III) complex [Au(dppta)(N Py-PZ-dtc)] (AuPyPZ) in liposomes. The liposomal form of compound AuPyPZ has a bactericidal action similar to that of the free drug without any appreciable effect on the viability of...

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Bibliographic Details
Published in:	Dalton transactions : an international journal of inorganic chemistry Vol. 53; no. 36; p. 15205
Main Authors:	Llamedo, Alejandro, Rodríguez, Pablo, Gabasa, Yaiza, Soengas, Raquel G, Rodríguez-Solla, Humberto, Elorriaga, David, García-Alonso, Francisco J, Soto, Sara M
Format:	Journal Article
Language:	English
Published:	England 18-09-2024
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Cell Survival - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Drug Resistance, Bacterial - drug effects Gold - chemistry Gold - pharmacology Humans Liposomes - chemistry Microbial Sensitivity Tests Organogold Compounds - chemical synthesis Organogold Compounds - chemistry Organogold Compounds - pharmacology
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Summary:	A novel lipoformulation was developed by encapsulating cationic (S^C)-cyclometallated gold(III) complex [Au(dppta)(N Py-PZ-dtc)] (AuPyPZ) in liposomes. The liposomal form of compound AuPyPZ has a bactericidal action similar to that of the free drug without any appreciable effect on the viability of mammalian cells. Furthermore, the nanoformulation reduces metalloantibiotic-induced inhibition of hERG and the inhibition of cytochromes, significantly decreasing the potential liabilities of the metallodrug. The obtained metalloantibiotic liposomal formulation shows high stability and suitable properties for drug delivery, representing an effective strategy to fight against drug-resistant bacteria.
ISSN:	1477-9234
DOI:	10.1039/d4dt01867b