Search Results - "Ljungstrom, Viktor"

Prognostic and Predictive Implications of Cytogenetics and Genomics by Ljungström, Viktor, Baliakas, Panagiotis

“…Chronic lymphocytic leukemia (CLL) is characterized by extreme genomic heterogeneity. Numerous recurrent genetic abnormalities are associated with dismal…”
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Not so lost in translation: RPS15 mutations in CLL by Ljungström, Viktor, Rosenquist, Richard

“…In this issue of Blood, Bretones et al expand knowledge of the functional consequences of recurrent mutations in RPS15, a gene that encodes a ribosomal protein…”
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Accurate and sensitive mutational signature analysis with MuSiCal by Jin, Hu, Gulhan, Doga C., Geiger, Benedikt, Ben-Isvy, Daniel, Geng, David, Ljungström, Viktor, Park, Peter J.

“…Mutational signature analysis is a recent computational approach for interpreting somatic mutations in the genome. Its application to cancer data has enhanced…”
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Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers by Kiflemariam, Sara, Ljungström, Viktor, Pontén, Fredrik, Sjöblom, Tobias

“…The tyrosine kinome and phosphatome harbor oncogenes and tumor suppressor genes and important regulators of angiogenesis and tumor stroma formation. To provide…”
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Five Percent Variant Allele Frequency Is a Reliable Reporting Threshold for TP53 Variants Detected by Next Generation Sequencing in Chronic Lymphocytic Leukemia in the Clinical Setting by Pandzic, Tatjana, Ladenvall, Claes, Engvall, Marie, Mattsson, Mattias, Hermanson, Monica, Cavelier, Lucia, Ljungström, Viktor, Baliakas, Panagiotis

“…The clinical significance of small TP53 clones detected with next generation sequencing (NGS) in chronic lymphocytic leukemia is an issue of active debate…”
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Bioinformatic Challenges in Clinical Diagnostic Application of Targeted Next Generation Sequencing: Experience from Pheochromocytoma by Crona, Joakim, Ljungström, Viktor, Welin, Staffan, Walz, Martin K, Hellman, Per, Björklund, Peyman

“…Recent studies have demonstrated equal quality of targeted next generation sequencing (NGS) compared to Sanger Sequencing. Whereas these novel sequencing…”
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Clonal hematopoiesis in patients with high‐grade B‐cell lymphoma is associated with inferior outcome by Amini, Rose‐Marie, Ljungström, Viktor, Abdulla, Maysaa, Cavelier, Lucia, Pandzic, Tatjana, Hollander, Peter, Enblad, Gunilla, Baliakas, Panagiotis

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BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib by Bonfiglio, Silvia, Sutton, Lesley-Ann, Ljungström, Viktor, Capasso, Antonella, Pandzic, Tatjana, Weström, Simone, Foroughi-Asl, Hassan, Skaftason, Aron, Gellerbring, Anna, Lyander, Anna, Gandini, Francesca, Gaidano, Gianluca, Trentin, Livio, Bonello, Lisa, Reda, Gianluigi, Bödör, Csaba, Stavroyianni, Niki, Tam, Constantine S., Marasca, Roberto, Forconi, Francesco, Panayiotidis, Panayiotis, Ringshausen, Ingo, Jaksic, Ozren, Frustaci, Anna Maria, Iyengar, Sunil, Coscia, Marta, Mulligan, Stephen P., Ysebaert, Loïc, Strugov, Vladimir, Pavlovsky, Carolina, Walewska, Renata, Österborg, Anders, Cortese, Diego, Ranghetti, Pamela, Baliakas, Panagiotis, Stamatopoulos, Kostas, Scarfò, Lydia, Rosenquist, Richard, Ghia, Paolo

“…•One-third of patients with CLL relapsing on ibrutinib do not carry BTK/PLCG2 mutations, even with a 0.1% sensitivity.•Additional mechanisms, such as del(8p),…”
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Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2 by Bhoi, Sujata, Ljungström, Viktor, Baliakas, Panagiotis, Mattsson, Mattias, Smedby, Karin E., Juliusson, Gunnar, Rosenquist, Richard, Mansouri, Larry

“…Based on the methylation status of 5 single CpG sites, a novel epigenetic classification of chronic lymphocytic leukemia (CLL) was recently proposed,…”
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Loss of Y and clonal hematopoiesis in blood—two sides of the same coin? by Ljungström, Viktor, Mattisson, Jonas, Halvardson, Jonatan, Pandzic, Tatjana, Davies, Hanna, Rychlicka-Buniowska, Edyta, Danielsson, Marcus, Lacaze, Paul, Cavelier, Lucia, Dumanski, Jan P., Baliakas, Panagiotis, Forsberg, Lars A.

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Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations by Ljungström, Viktor, Cortese, Diego, Young, Emma, Pandzic, Tatjana, Mansouri, Larry, Plevova, Karla, Ntoufa, Stavroula, Baliakas, Panagiotis, Clifford, Ruth, Sutton, Lesley-Ann, Blakemore, Stuart J., Stavroyianni, Niki, Agathangelidis, Andreas, Rossi, Davide, Höglund, Martin, Kotaskova, Jana, Juliusson, Gunnar, Belessi, Chrysoula, Chiorazzi, Nicholas, Panagiotidis, Panagiotis, Langerak, Anton W., Smedby, Karin E., Oscier, David, Gaidano, Gianluca, Schuh, Anna, Davi, Frederic, Pott, Christiane, Strefford, Jonathan C., Trentin, Livio, Pospisilova, Sarka, Ghia, Paolo, Stamatopoulos, Kostas, Sjöblom, Tobias, Rosenquist, Richard

“…Fludarabine, cyclophosphamide, and rituximab (FCR) is first-line treatment of medically fit chronic lymphocytic leukemia (CLL) patients; however, despite good…”
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Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing by Parry, Marina, Rose-Zerilli, Matthew Jj, Ljungström, Viktor, Gibson, Jane, Wang, Jun, Walewska, Renata, Parker, Helen, Parker, Anton, Davis, Zadie, Gardiner, Anne, McIver-Brown, Neil, Kalpadakis, Christina, Xochelli, Aliki, Anagnostopoulos, Achilles, Fazi, Claudia, de Castro, David Gonzalez, Dearden, Claire, Pratt, Guy, Rosenquist, Richard, Ashton-Key, Margaret, Forconi, Francesco, Collins, Andrew, Ghia, Paolo, Matutes, Estella, Pangalis, Gerassimos, Stamatopoulos, Kostas, Oscier, David, Strefford, Jonathan C

“…Mounting evidence supports the clinical significance of gene mutations and immunogenetic features in common mature B-cell malignancies. We undertook a detailed…”
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SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts by Malcovati, Luca, Karimi, Mohsen, Papaemmanuil, Elli, Ambaglio, Ilaria, Jädersten, Martin, Jansson, Monika, Elena, Chiara, Gallì, Anna, Walldin, Gunilla, Della Porta, Matteo G., Raaschou-Jensen, Klas, Travaglino, Erica, Kallenbach, Klaus, Pietra, Daniela, Ljungström, Viktor, Conte, Simona, Boveri, Emanuela, Invernizzi, Rosangela, Rosenquist, Richard, Campbell, Peter J., Cazzola, Mario, Hellström Lindberg, Eva

“…Refractory anemia with ring sideroblasts (RARS) is a myelodysplastic syndrome (MDS) characterized by isolated erythroid dysplasia and 15% or more bone marrow…”
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Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations by Agathangelidis, Andreas, Ljungström, Viktor, Scarfò, Lydia, Fazi, Claudia, Gounari, Maria, Pandzic, Tatjana, Sutton, Lesley-Ann, Stamatopoulos, Kostas, Tonon, Giovanni, Rosenquist, Richard, Ghia, Paolo

“…Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely…”
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Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer by Rendo, Veronica, Kundu, Snehangshu, Rameika, Natallia, Ljungström, Viktor, Svensson, Richard, Palin, Kimmo, Aaltonen, Lauri, Stoimenov, Ivaylo, Sjöblom, Tobias

“…Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC)…”
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ERα-associated translocations underlie oncogene amplifications in breast cancer by Lee, Jake June-Koo, Jung, Youngsook Lucy, Cheong, Taek-Chin, Espejo Valle-Inclan, Jose, Chu, Chong, Gulhan, Doga C., Ljungström, Viktor, Jin, Hu, Viswanadham, Vinayak V., Watson, Emma V., Cortés-Ciriano, Isidro, Elledge, Stephen J., Chiarle, Roberto, Pellman, David, Park, Peter J.

“…Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure 1 – 3 and the evolutionary trajectories 4 of…”
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Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort by Mathioudaki, Argyri, Ljungström, Viktor, Melin, Malin, Arendt, Maja Louise, Nordin, Jessika, Karlsson, Åsa, Murén, Eva, Saksena, Pushpa, Meadows, Jennifer R. S., Marinescu, Voichita D., Sjöblom, Tobias, Lindblad-Toh, Kerstin

“…Breast cancer (BC) is a genetically heterogeneous disease with high prevalence in Northern Europe. However, there has been no detailed investigation into the…”
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Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis by Nunes, Luís, Aasebø, Kristine, Mathot, Lucy, Ljungström, Viktor, Edqvist, Per-Henrik, Sundström, Magnus, Dragomir, Anca, Pfeiffer, Per, Ameur, Adam, Ponten, Fredrik, Mezheyeuski, Artur, Sorbye, Halfdan, Sjöblom, Tobias, Glimelius, Bengt

“…We have reported that V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal…”
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Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study by Sutton, Lesley-Ann, Ljungström, Viktor, Enjuanes, Anna, Cortese, Diego, Skaftason, Aron, Tausch, Eugen, Stano Kozubik, Katerina, Nadeu, Ferran, Armand, Marine, Malcikova, Jikta, Pandzic, Tatjana, Forster, Jade, Davis, Zadie, Oscier, David, Rossi, Davide, Ghia, Paolo, Strefford, Jonathan C, Pospisilova, Sarka, Stilgenbauer, Stephan, Davi, Frederic, Campo, Elias, Stamatopoulos, Kostas, Rosenquist, Richard, On Behalf Of The European Research Initiative On Cll Eric

“…Next-generation sequencing (NGS) has transitioned from research to clinical routine, yet the comparability of different technologies for mutation profiling…”
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Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer by Mathot, Lucy, Kundu, Snehangshu, Ljungström, Viktor, Svedlund, Jessica, Moens, Lotte, Adlerteg, Tom, Falk-Sörqvist, Elin, Rendo, Verónica, Bellomo, Claudia, Mayrhofer, Markus, Cortina, Carme, Sundström, Magnus, Micke, Patrick, Botling, Johan, Isaksson, Anders, Moustakas, Aristidis, Batlle, Eduard, Birgisson, Helgi, Glimelius, Bengt, Nilsson, Mats, Sjöblom, Tobias

“…The contribution of somatic mutations to metastasis of colorectal cancers is currently unknown. To find mutations involved in the colorectal cancer metastatic…”
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