Search Results - "Liyanage, Namal P. M."

Evaluation of early innate and adaptive immune responses to the TB vaccine Mycobacterium bovis BCG and vaccine candidate BCGΔBCG1419c by Gunasena, Manuja, Shukla, Rajni Kant, Yao, Naiquan, Rosas Mejia, Oscar, Powell, Michael D., Oestreich, Kenneth J., Aceves-Sánchez, Michel de Jesús, Flores-Valdez, Mario Alberto, Liyanage, Namal P. M., Robinson, Richard T.

“…The vaccine Mycobacterium bovis Bacillus Calmette-Guérin (BCG) elicits an immune response that is protective against certain forms of tuberculosis (TB);…”
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Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology by Song, No-Joon, Allen, Carter, Vilgelm, Anna E, Riesenberg, Brian P, Weller, Kevin P, Reynolds, Kelsi, Chakravarthy, Karthik B, Kumar, Amrendra, Khatiwada, Aastha, Sun, Zequn, Ma, Anjun, Chang, Yuzhou, Yusuf, Mohamed, Li, Anqi, Zeng, Cong, Evans, John P, Bucci, Donna, Gunasena, Manuja, Xu, Menglin, Liyanage, Namal P M, Bolyard, Chelsea, Velegraki, Maria, Liu, Shan-Lu, Ma, Qin, Devenport, Martin, Liu, Yang, Zheng, Pan, Malvestutto, Carlos D, Chung, Dongjun, Li, Zihai

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) through direct lysis of infected lung epithelial cells,…”
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Correction: ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type by Schifanella, Luca, Barnett, Susan W, Bissa, Massimiliano, Galli, Veronica, Doster, Melvin N, Vaccari, Monica, Tomaras, Georgia D, Shen, Xiaoying, Phogat, Sanjay, Pal, Ranajit, Montefiori, David C, LaBranche, Celia C, Rao, Mangala, Trinh, Hung V, Washington-Parks, Robyn, Liyanage, Namal P M, Gorini, Giacomo, Brown, Dallas R, Liang, Frank, Loré, Karin, Venzon, David J, Magnanelli, William, Metrinko, Michelle, Kramer, Josh, Breed, Matthew, Alter, Galit, Ruprecht, Ruth M, Franchini, Genoveffa

“…[This corrects the article DOI: 10.1371/journal.ppat.1008121.]…”
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Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity by Kim, Eunsoo, Attia, Zayed, Woodfint, Rachel M., Zeng, Cong, Kim, Sun Hee, Steiner, Haley E., Shukla, Rajni Kant, Liyanage, Namal P. M., Ghimire, Shristi, Li, Jianrong, Renukaradhya, Gourapura J., Satoskar, Abhay R., Amer, Amal O., Liu, Shan-Lu, Cormet-Boyaka, Estelle, Boyaka, Prosper N.

“…Alum, used as an adjuvant in injected vaccines, promotes T helper 2 (Th2) and serum antibody (Ab) responses. However, it fails to induce secretory…”
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HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition by Vaccari, Monica, Fourati, Slim, Gordon, Shari N., Brown, Dallas R., Bissa, Massimilano, Schifanella, Luca, Silva de Castro, Isabela, Doster, Melvin N., Galli, Veronica, Omsland, Maria, Fujikawa, Dai, Gorini, Giacomo, Liyanage, Namal P. M., Trinh, Hung V., McKinnon, Katherine M., Foulds, Kathryn E., Keele, Brandon F., Roederer, Mario, Koup, Richard A., Shen, Xiaoying, Tomaras, Georgia D., Wong, Marcus P., Munoz, Karissa J., Gach, Johannes S., Forthal, Donald N., Montefiori, David C., Venzon, David J., Felber, Barbara K., Rosati, Margherita, Pavlakis, George N., Rao, Mangala, Sekaly, Rafick-Pierre, Franchini, Genoveffa

“…Qualitative differences in the innate and adaptive responses elicited by different HIV vaccine candidates have not been thoroughly investigated. We tested the…”
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Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections by Ahmed-Hassan, Hanaa, Sisson, Brianna, Shukla, Rajni Kant, Wijewantha, Yasasvi, Funderburg, Nicholas T, Li, Zihai, Hayes, Jr, Don, Demberg, Thorsten, Liyanage, Namal P M

“…The new pandemic virus SARS-CoV-2 emerged in China and spread around the world in <3 months, infecting millions of people, and causing countries to shut down…”
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Innate adaptive immune cell dynamics in tonsillar tissues during chronic SIV infection by Shukla, Rajni Kant, Gunasena, Manuja, Reinhold-Larsson, Nicole, Duncan, Michael, Hatharasinghe, Amila, Cray, Samuel, Weragalaarachchi, Krishanthi, Kasturiratna, Dhanuja, Demberg, Thorsten, Liyanage, Namal P. M.

“…HIV-infected patients are at higher risk of developing oral mucosal infection and Epstein–Barr virus (EBV)-associated B cell malignancies. However, the…”
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Estrogen May Enhance Toll-Like Receptor 4-Induced Inflammatory Pathways in People With HIV: Implications for Transgender Women on Hormone Therapy by Kettelhut, Aaren, Bowman, Emily, Gabriel, Janelle, Hand, Brittany, Liyanage, Namal P M, Kulkarni, Manjusha, Avila-Soto, Frances, Lake, Jordan E, Funderburg, Nicholas T

“…Transgender women (TW) are at increased risk for both human immunodeficiency virus (HIV) and cardiovascular disease (CVD). Antiretroviral therapy-treated HIV…”
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Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition by Gorini, Giacomo, Fourati, Slim, Vaccari, Monica, Rahman, Mohammad Arif, Gordon, Shari N, Brown, Dallas R, Law, Lynn, Chang, Jean, Green, Richard, Barrenäs, Fredrik, Liyanage, Namal P M, Doster, Melvin N, Schifanella, Luca, Bissa, Massimiliano, Silva de Castro, Isabela, Washington-Parks, Robyn, Galli, Veronica, Fuller, Deborah H, Santra, Sampa, Agy, Michael, Pal, Ranajit, Palermo, Robert E, Tomaras, Georgia D, Shen, Xiaoying, LaBranche, Celia C, Montefiori, David C, Venzon, David J, Trinh, Hung V, Rao, Mangala, Gale, Jr, Michael, Sekaly, Rafick P, Franchini, Genoveffa

“…The recombinant Canarypox ALVAC-HIV/gp120/alum vaccine regimen was the first to significantly decrease the risk of HIV acquisition in humans, with equal…”
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CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells by Kim, Shihyoung, Shukla, Rajni Kant, Yu, Hannah, Baek, Alice, Cressman, Sophie G., Golconda, Sarah, Lee, Ga-Eun, Choi, Hyewon, Reneau, John C., Wang, Zhirui, Huang, Christene A., Liyanage, Namal P. M., Kim, Sanggu

“…CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows…”
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ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type by Schifanella, Luca, Barnett, Susan W, Bissa, Massimiliano, Galli, Veronica, Doster, Melvin N, Vaccari, Monica, Tomaras, Georgia D, Shen, Xiaoying, Phogat, Sanjay, Pal, Ranajit, Montefiori, David C, LaBranche, Celia C, Rao, Mangala, Trinh, Hung V, Washington-Parks, Robyn, Liyanage, Namal P M, Gorini, Giacomo, Brown, Dallas R, Liang, Frank, Loré, Karin, Venzon, David J, Magnanelli, William, Metrinko, Michelle, Kramer, Josh, Breed, Matthew, Alter, Galit, Ruprecht, Ruth M, Franchini, Genoveffa

“…The ALVAC-HIV clade B/AE and equivalent SIV-based/gp120 + Alum vaccines successfully decreased the risk of virus acquisition in humans and macaques. Here, we…”
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Lung T-Cell Profile Alterations are Associated with Bronchiolitis Obliterans Syndrome in Cystic Fibrosis Lung Transplant Recipients by Hayes, Don, Harhay, Michael O., Nicol, Kathleen K., Liyanage, Namal P. M., Keller, Brian C., Robinson, Richard T.

“…The contribution of T-cells after lung transplant (LTx) remains controversial with no current consensus of their role concerning chronic lung allograft…”
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SARS‐CoV‐2 infection of companion animals in Egypt and its risk of spillover by Hamdy, Mervat E., El‐Deeb, Ayman H., Hagag, Naglaa M., Shahein, Momtaz A., Liyanage, Namal P. M., Shalaan, Mohamed, Hussein, Hussein A.

“…Background Reverse zoonoses occur because of interactions between humans and animals. Homology of ACE‐2 cell receptors in different hosts and high mutation…”
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Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition by Gordon, Shari N, Liyanage, Namal P M, Doster, Melvin N, Vaccari, Monica, Vargas-Inchaustegui, Diego A, Pegu, Poonam, Schifanella, Luca, Shen, Xiaoying, Tomaras, Georgia D, Rao, Mangala, Billings, Erik A, Schwartz, Jennifer, Prado, Ilia, Bobb, Kathryn, Zhang, Wenlei, Montefiori, David C, Foulds, Kathryn E, Ferrari, Guido, Robert-Guroff, Marjorie, Roederer, Mario, Phan, Tran B, Forthal, Donald N, Stablein, Donald M, Phogat, Sanjay, Venzon, David J, Fouts, Timothy, Franchini, Genoveffa

“…The recombinant ALVAC vaccine coupled with the monomeric gp120/alum protein have decreased the risk of HIV and SIV acquisition. Ab responses to the V1/V2…”
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Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia by Gordon, Shari N, Doster, Melvin N, Kines, Rhonda C, Keele, Brandon F, Brocca-Cofano, Egidio, Guan, Yongjun, Pegu, Poonam, Liyanage, Namal P M, Vaccari, Monica, Cuburu, Nicolas, Buck, Christopher B, Ferrari, Guido, Montefiori, David, Piatak, Jr, Michael, Lifson, Jeffrey D, Xenophontos, Anastasia M, Venzon, David, Robert-Guroff, Marjorie, Graham, Barney S, Lowy, Douglas R, Schiller, John T, Franchini, Genoveffa

“…The human papillomavirus pseudovirions (HPV-PsVs) approach is an effective gene-delivery system that can prime or boost an immune response in the vaginal tract…”
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Comparison of CD3e Antibody and CD3e-sZAP Immunotoxin Treatment in Mice Identifies sZAP as the Main Driver of Vascular Leakage by Kim, Shihyoung, Shukla, Rajni Kant, Kim, Eunsoo, Cressman, Sophie G, Yu, Hannah, Baek, Alice, Choi, Hyewon, Kim, Alan, Sharma, Amit, Wang, Zhirui, Huang, Christene A, Reneau, John C, Boyaka, Prosper N, Liyanage, Namal P M, Kim, Sanggu

“…Anti-CD3-epsilon (CD3e) monoclonal antibodies (mAbs) and CD3e immunotoxins (ITs) are promising targeted therapy options for various T-cell disorders. Despite…”
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Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques by Valentin, Antonio, McKinnon, Katherine, Li, Jinyao, Rosati, Margherita, Kulkarni, Viraj, Pilkington, Guy R, Bear, Jenifer, Alicea, Candido, Vargas-Inchaustegui, Diego A, Jean Patterson, L, Pegu, Poonam, Liyanage, Namal P.M, Gordon, Shari N, Vaccari, Monica, Wang, Yichuan, Hogg, Alison E, Frey, Blake, Sui, Yongjun, Reed, Steven G, Sardesai, Niranjan Y, Berzofsky, Jay A, Franchini, Genoveffa, Robert-Guroff, Marjorie, Felber, Barbara K, Pavlakis, George N

“…Abstract To identify the most promising vaccine candidates for combinatorial strategies, we compared five SIV vaccine platforms including recombinant canary…”
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Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir by Moniuszko, Marcin, Liyanage, Namal P M, Doster, Melvin N, Parks, Robyn Washington, Grubczak, Kamil, Lipinska, Danuta, McKinnon, Katherine, Brown, Charles, Hirsch, Vanessa, Vaccari, Monica, Gordon, Shari, Pegu, Poonam, Fenizia, Claudio, Flisiak, Robert, Grzeszczuk, Anna, Dabrowska, Milena, Robert-Guroff, Marjorie, Silvestri, Guido, Stevenson, Mario, McCune, Joseph, Franchini, Genoveffa

“…Subsets of CD16-positive monocytes produce proinflammatory cytokines and expand during chronic infection with the human immunodeficiency virus type 1 (HIV)…”
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BCG immunization induced KLRG1+ NK cells show memory-like responses to mycobacterial and HIV antigens by Gunasena, Manuja, Alles, Mario, Demberg, Thorsten, Mulhern, Will, Liyanage, Namal P.M.

“…•Here, we demonstrate that the BCG vaccine induces memory-like traits in NK cells extending beyond tuberculosis.•BCG expands a subset of KLRG1+ NK cells which…”
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Contribution of Helicobacter hepaticus Cytolethal Distending Toxin Subunits to Human Epithelial Cell Cycle Arrest and Apoptotic Death in vitro by Liyanage, Namal P.M., Dassanayake, Rohana P., Kuszynski, Charles A., Duhamel, Gerald E.

“…Background Cytolethal distending toxin (CDT) is the only known virulence factor found in H. hepaticus, the cause of chronic typhlocolitis and hepatitis leading…”
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