Search Results - "Livneh, Zvi"

Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis by Livneh, Zvi, Z, Omer, Shachar, Sigal

“…The encounter of replication forks with DNA lesions may lead to fork arrest and/or the formation of single-stranded gaps. A major strategy to cope with these…”
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Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining by Feldman, Tzah, Bercovich, Akhiad, Moskovitz, Yoni, Chapal-Ilani, Noa, Mitchell, Amanda, Medeiros, Jessie J. F., Biezuner, Tamir, Kaushansky, Nathali, Minden, Mark D., Gupta, Vikas, Milyavsky, Michael, Livneh, Zvi, Tanay, Amos, Shlush, Liran I.

“…The mutational mechanisms underlying recurrent deletions in clonal hematopoiesis are not entirely clear. In the current study we inspect the genomic regions…”
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Keeping Mammalian Mutation Load in Check: Regulation of the Activity of Error-Prone DNA Polymerases by p53 and p21 by Livneh, Zvi

“…To overcome DNA lesions that block replication the cell employs translesion DNA synthesis (TLS) polymerases, a group of low fidelity DNA polymerases that have…”
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Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals by Shachar, Sigal, Ziv, Omer, Avkin, Sharon, Adar, Sheera, Wittschieben, John, Reißner, Thomas, Chaney, Stephen, Friedberg, Errol C, Wang, Zhigang, Carell, Thomas, Geacintov, Nicholas, Livneh, Zvi

“…DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect…”
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Multi-center nationwide comparison of seven serology assays reveals a SARS-CoV-2 non-responding seronegative subpopulation by Oved, Kfir, Olmer, Liraz, Shemer-Avni, Yonat, Wolf, Tamar, Supino-Rosin, Lia, Prajgrod, George, Shenhar, Yotam, Payorsky, Irina, Cohen, Yuval, Kohn, Yishai, Indenbaum, Victoria, Lazar, Rachel, Geylis, Valeria, Oikawa, Michal Tepperberg, Shinar, Eilat, Stoyanov, Evgeniy, Keinan-Boker, Lital, Bassal, Ravit, Reicher, Shay, Yishai, Ruti, Bar-Chaim, Adina, Doolman, Ram, Reiter, Yoram, Mendelson, Ella, Livneh, Zvi, Freedman, Laurence S., Lustig, Yaniv

“…An Israeli national taskforce performed a multi-center clinical and analytical validation of seven serology assays to determine their utility and limitations…”
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DNA polymerase ζ cooperates with polymerases κ and ι in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients by Ziv, Omer, Geacintov, Nicholas, Nakajima, Satoshi, Yasui, Akira, Livneh, Zvi

“…Human cells tolerate UV-induced cyclobutane pyrimidine dimers (CPD) by translesion DNA synthesis (TLS), carried out by DNA polymerase η, the POLH gene product…”
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability by Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Giakoumakis, Nickolaos N, Glytsou, Christina, Pateras, Ioannis S, Swain, Umakanta, Souliotis, Vassilis L, Georgakilas, Alexandros G, Geacintov, Nicholas, Scorrano, Luca, Lukas, Claudia, Lukas, Jiri, Livneh, Zvi, Lygerou, Zoi, Chowdhury, Dipanjan, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G

“…Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic…”
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Improved sensitivity, safety, and rapidity of COVID-19 tests by replacing viral storage solution with lysis buffer by Erster, Oran, Shkedi, Omer, Benedek, Gil, Zilber, Eyal, Varkovitzky, Itay, Shirazi, Rachel, Oriya Shorka, Dorit, Cohen, Yuval, Bar, Tzahi, Yechieli, Rafi, Tepperberg Oikawa, Michal, Venkert, Dana, Linial, Michal, Oiknine-Djian, Esther, Mandelboim, Michal, Livneh, Zvi, Shenhav-Saltzman, Gilat, Mendelson, Ella, Wolf, Dana, Szwarcwort-Cohen, Moran, Mor, Orna, Lewis, Yair, Zeevi, Danny

“…Conducting numerous, rapid, and reliable PCR tests for SARS-CoV-2 is essential for our ability to monitor and control the current COVID-19 pandemic. Here, we…”
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DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention by Paz-Elizur, Tamar, Sevilya, Ziv, Leitner-Dagan, Yael, Elinger, Dalia, Roisman, Laila C, Livneh, Zvi

“…Abstract Efficient DNA repair mechanisms comprise a critical component in the protection against human cancer, as indicated by the high predisposition to…”
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TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer by Swain, Umakanta, Friedlander, Gilgi, Sehrawat, Urmila, Sarusi-Portuguez, Avital, Rotkopf, Ron, Ebert, Charlotte, Paz-Elizur, Tamar, Dikstein, Rivka, Carell, Thomas, Geacintov, Nicholas E., Livneh, Zvi

“…TENT4A (PAPD7) is a non-canonical poly(A) polymerase, of which little is known. Here, we show that TENT4A regulates multiple biological pathways and focuses on…”
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PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells by Hendel, Ayal, Krijger, Peter H L, Diamant, Noam, Goren, Zohar, Langerak, Petra, Kim, Jungmin, Reissner, Thomas, Lee, Kyoo-young, Geacintov, Nicholas E, Carell, Thomas, Myung, Kyungjae, Tateishi, Satoshi, D'Andrea, Alan, Jacobs, Heinz, Livneh, Zvi

“…Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and…”
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Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells by Izhar, Lior, Ziv, Omer, Cohen, Isadora S, Geacintov, Nicholas E, Livneh, Zvi

“…DNA lesions can block replication forks and lead to the formation of single-stranded gaps. These replication complications are mitigated by DNA damage…”
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Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin by Ziv, Omer, Zeisel, Amit, Mirlas-Neisberg, Nataly, Swain, Umakanta, Nevo, Reinat, Ben-Chetrit, Nir, Martelli, Maria Paola, Rossi, Roberta, Schiesser, Stefan, Canman, Christine E., Carell, Thomas, Geacintov, Nicholas E., Falini, Brunangelo, Domany, Eytan, Livneh, Zvi

“…Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across…”
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Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability by Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Giakoumakis, Nickolaos N, Glytsou, Christina, Pateras, Ioannis S, Swain, Umakanta, Souliotis, Vassilis L, Georgakilas, Alexandros G, Geacintov, Nicholas, Scorrano, Luca, Lukas, Claudia, Lukas, Jiri, Livneh, Zvi, Lygerou, Zoi, Chowdhury, Dipanjan, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G

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DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes by Cohen, Isadora S, Bar, Carmit, Paz-Elizur, Tamar, Ainbinder, Elena, Leopold, Karoline, de Wind, Niels, Geacintov, Nicholas, Livneh, Zvi

“…DNA-damage tolerance (DDT) via translesion DNA synthesis (TLS) or homology-dependent repair (HDR) functions to bypass DNA lesions encountered during…”
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p53 and p21 Regulate Error-Prone DNA Repair to Yield a Lower Mutation Load by Avkin, Sharon, Sevilya, Ziv, Toube, Leanne, Geacintov, Nicholas, Chaney, Stephen G., Oren, Moshe, Livneh, Zvi

“…Regulation of mutation rates is critical for maintaining genome stability and controlling cancer risk. A special challenge to this regulation is the presence…”
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Separate Domains of Rev1 Mediate Two Modes of DNA Damage Bypass in Mammalian Cells by Jansen, Jacob G., Tsaalbi-Shtylik, Anastasia, Hendriks, Giel, Gali, Himabindu, Hendel, Ayal, Johansson, Fredrik, Erixon, Klaus, Livneh, Zvi, Mullenders, Leon H. F., Haracska, Lajos, de Wind, Niels

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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DNA Molecule Provides a Computing Machine with Both Data and Fuel by Benenson, Yaakov, Adar, Rivka, Paz-Elizur, Tamar, Livneh, Zvi, Shapiro, Ehud

“…The unique properties of DNA make it a fundamental building block in the fields of supramolecular chemistry, nanotechnology, nano-circuits, molecular switches,…”
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The Mutagenesis Protein UmuC Is a DNA Polymerase Activated by UmuD′, RecA, and SSB and Is Specialized for Translesion Replication by Reuven, Nina Bacher, Arad, Gali, Maor-Shoshani, Ayelet, Livneh, Zvi

“…Replication of DNA lesions leads to the formation of mutations. In Escherichia coli this process is regulated by the SOS stress response, and requires the…”
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Single-stranded DNA-binding Protein Recruits DNA Polymerase V to Primer Termini on RecA-coated DNA by Arad, Gali, Hendel, Ayal, Urbanke, Claus, Curth, Ute, Livneh, Zvi

“…Translesion DNA synthesis (TLS) by DNA polymerase V (polV) in Escherichia coli involves accessory proteins, including RecA and single-stranded DNA-binding…”
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