Search Results - "Livi, G P"

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity by CAFFERKEY, R, YOUNG, P. R, MCLAUGHLIN, M. M, BERGSMA, D. J, KOLTIN, Y, SATHE, G. M, FAUCETTE, L, WAI-KWONG ENG, JOHNSON, R. K, LIVI, G. P

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Candida albicans ALS1: domains related to a Saccharomyces cerevisiae sexual agglutinin separated by a repeating motif by Hoyer, L L, Scherer, S, Shatzman, A R, Livi, G P

“…Transfer of budding Candida albicans yeast cells from the rich, complex medium YEPD to the defined tissue culture medium RPMI 1640 (RPMI) at 37 degrees C and…”
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Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue by Stan, R, McLaughlin, M M, Cafferkey, R, Johnson, R K, Rosenberg, M, Livi, G P

“…The yeast TOR1 and TOR2 proteins were previously discovered as putative targets of the immunosuppressive drug rapamycin. Although their cellular function is…”
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Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein by KOLTIN, Y, FAUCETTE, L, BERGSMA, D. J, LEVY, M. A, CAFFERKEY, R, KOSER, P. L, JOHNSON, R. K, LIVI, G. P

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis by Lee, John C, Laydon, Jeffrey T, McDonnell, Peter C, Gallagher, Timothy F, Kumar, Sanjay, Green, David, McNulty, Dean, Blumenthal, Mary Jane, Keys, J. Richard, Land vatter, Scott W, Strickler, James E, McLaughlin, Megan M, Siemens, Ivo R, Fisher, Seth M, Livi, George P, White, John R, Adams, Jerry L, Young, Peter R

“…Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using…”
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Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding by Jacobitz, S, McLaughlin, M M, Livi, G P, Burman, M, Torphy, T J

“…To identify functional domains of the 886-amino acid human recombinant cAMP-specific phosphodiesterase (PDE) subtype A (rhPDE4A), we engineered the expression…”
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Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast by Torphy, T J, Stadel, J M, Burman, M, Cieslinski, L B, McLaughlin, M M, White, J R, Livi, G P

“…Studies by various investigators have demonstrated that the low Km, cAMP-specific phosphodiesterase (PDE IV) is selectively inhibited by a group of compounds…”
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A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA by MCLAUGHLIN, M. M, CIESLINSKI, L. B, BURMAN, M, TORPHY, T. J, LIVI, G. P

“…We have isolated cDNA clones from human frontal cortex cDNA libraries that encode a unique subtype of the low-Km, cAMP-specific phosphodiesterases (PDEs IV)…”
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Oligonucleotide-mediated, PCR-independent cloning by homologous recombination by DeMarini, D J, Creasy, C L, Lu, Q, Mao, J, Sheardown, S A, Sathe, G M, Livi, G P

“…We have developed an oligonucleotide-mediated cloning technique based on homologous recombination in Saccharomyces cerevisiae that allows precise DNA sequences…”
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Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B by Manning, C D, McLaughlin, M M, Livi, G P, Cieslinski, L B, Torphy, T J, Barnette, M S

“…Human peripheral blood monocytes were treated for 4 h with a combination of the beta-agonist salbutamol (3 microM) and the low-Km cAMP-specific…”
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Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase by LIVI, G. P, KMETZ, P, MCHALE, M. M, CIESLINSKI, L. B, SATHE, G. M, TAYLOR, D. P, DAVIS, R. L, TORPHY, T. J, BALCAREK, J. M

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A Candida albicans cyclic nucleotide phosphodiesterase: cloning and expression in Saccharomyces cerevisiae and biochemical characterization of the recombinant enzyme by HOYER, L. L, CIESLINSKI, L. B, MCLAUGHLIN, M. M, TORPHY, T. J, SHATZMAN, A. R, LIVI, G. P

“…1 Department of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA 2 Department of Pharmacology, SmithKline…”
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Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor by Truneh, A, Sharma, S, Silverman, C, Khandekar, S, Reddy, M P, Deen, K C, McLaughlin, M M, Srinivasula, S M, Livi, G P, Marshall, L A, Alnemri, E S, Williams, W V, Doyle, M L

“…TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptotic cell death in a variety of tumor cell lines. It mediates its…”
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A G Protein-coupled Receptor for UDP-glucose by Chambers, Jon K., Macdonald, Lynn E., Sarau, Henry M., Ames, Robert S., Freeman, Katie, Foley, James J., Zhu, Yuan, McLaughlin, Megan M., Murdock, Paul, McMillan, Lynette, Trill, John, Swift, Ann, Aiyar, Nambi, Taylor, Paul, Vawter, Lisa, Naheed, Sajda, Szekeres, Philip, Hervieu, Guillaume, Scott, Claire, Watson, Jeanette M., Murphy, Andrew J., Duzic, Emir, Klein, Christine, Bergsma, Derk J., Wilson, Shelagh, Livi, George P.

“…Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is…”
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Secretion of N-glycosylated interleukin-1 beta in Saccharomyces cerevisiae using a leader peptide from Candida albicans. Effect of N-linked glycosylation on biological activity by LIVI, G. P, LILLQUIST, J. S, MILES, L. M, FERRARA, A, SATHE, G. M, SIMON, P. L, MEYERS, C. A, GORMAN, J. A, YOUNG, P. R

“…Human interleukin-1 beta (IL-1 beta) is expressed in activated monocytes as a 31-kDa precursor protein which is processed and secreted as a mature,…”
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Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site by Young, P R, McLaughlin, M M, Kumar, S, Kassis, S, Doyle, M L, McNulty, D, Gallagher, T F, Fisher, S, McDonnell, P C, Carr, S A, Huddleston, M J, Seibel, G, Porter, T G, Livi, G P, Adams, J L, Lee, J C

“…The site of action of a series of pyridinyl imidazole compounds that are selective inhibitors of p38 mitogen-activated protein kinase in vitro and block…”
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Use of polymerase chain reaction for rapid detection of gene insertions in whole yeast cells by Sathe, G.M, O'Brien, S, McLaughlin, M.M, Watson, F, Livi, G.P

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Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase by McLaughlin, M M, Kumar, S, McDonnell, P C, Van Horn, S, Lee, J C, Livi, G P, Young, P R

“…CSBP p38 is a mitogen-activated protein kinase that is activated in response to stress, endotoxin, interleukin 1, and tumor necrosis factor. Using a…”
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Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket by Gum, R J, McLaughlin, M M, Kumar, S, Wang, Z, Bower, M J, Lee, J C, Adams, J L, Livi, G P, Goldsmith, E J, Young, P R

“…Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase compete with ATP for binding. Mutation of 23 residues in the ATP pocket indicated that…”
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Expression of dopamine beta-hydroxylase in Drosophila Schneider 2 cells. Evidence for a mechanism of membrane binding other than uncleaved signal peptide by GIBSON, K. R, VANEK, P. G, KALOSS, W. D, COLLIER, G. B, CONNAUGHTON, J. F, ANGELICHIO, M, LIVI, G. P, FLEMING, P. J

“…To characterize the mechanism of membrane attachment of dopamine beta-hydroxylase, an expression system producing the processed form of this enzyme has been…”
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