Search Results - "Liverton, N J"

Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway by Ayala, Julia M., Goyal, Shefali, Liverton, Nigel J., Claremon, Dave A., O'Keefe, Stephen J., Hanlon, William A.

“…Regulation by the p38 mitogen‐activated protein (MAP) kinase signaling pathway of monocytic inflammatory functions was evaluated using L‐790,070, a potent and…”
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Nonpeptide glycoprotein IIb/IIIa inhibitors: Substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists by Liverton, Nigel J., Armstrong, Donna J., Claremon, David A., Remy, David C., Baldvin, John J., Lynch, Robert J., Zhang, Guixiang, Gould, Robert J.

“…The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds…”
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Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase by Liverton, Nigel J, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Libby, Brian E, Nguyen, Kevin T, Pitzenberger, Steven M, Selnick, Harold G, Smith, Garry R, Tebben, Andrew, Vacca, Joseph P, Varga, Sandor L, Agarwal, Lily, Dancheck, Kim, Forsyth, Amy J, Fletcher, Daniel S, Frantz, Betsy, Hanlon, William A, Harper, Coral F, Hofsess, Scott J, Kostura, Matthew, Lin, Jiunn, Luell, Sylvie, O'Neill, Edward A, Orevillo, Chad J, Pang, Margaret, Parsons, Janey, Rolando, Anna, Sahly, Yousif, Visco, Denise M, O'Keefe, Stephen J

“…Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays…”
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Total synthesis of (+)-latrunculin B by Zibuck, Regina, Liverton, Nigel J, Smith, Amos B

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Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation by Trotter, B. Wesley, Nanda, Kausik K, Kett, Nathan R, Regan, Christopher P, Lynch, Joseph J, Stump, Gary L, Kiss, Laszlo, Wang, Jixin, Spencer, Robert H, Kane, Stefanie A, White, Rebecca B, Zhang, Rena, Anderson, Kenneth D, Liverton, Nigel J, McIntyre, Charles J, Beshore, Douglas C, Hartman, George D, Dinsmore, Christopher J

“…Novel 3-cyanoisoquinoline Kv1.5 antagonists have been prepared and evaluated in in vitro and in vivo assays for inhibition of the Kv1.5 potassium channel and…”
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Total synthesis of (+)-latrunculin A by Smith, Amos B., Noda, Ichio, Remiszewski, Stacy W., Liverton, Nigel J., Zibuck, Regina

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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide by SELNICK, Harold G., LIVERTON, Nigel J., BALDWIN, John J., BUTCHER, John W., CLAREMON, David A., ELLIOTT, Jason M., FREIDINGER, Roger M., KING, Stella A., LIBBY, Brian E., MCINTYRE, Charles J., PRIBUSH, David A., REMY, David C., SMITH, Garry R., TEBBEN, Andrew J., JURKIEWICZ, Nancy K., LYNCH, Joseph J., SALATA, Joseph J., SANGUINETTI, Michael C., SIEGL, Peter K. S., SLAUGHTER, Donald E., VYAS, Kamlesh

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An efficient photochemical approach to the trans-bicyclo[5.1.0]octene ring system by Wood, John L, Liverton, Nigel J, Visnick, Melean, Smith, Amos B

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Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia by Lynch, Jr, J J, Houle, M S, Stump, G L, Wallace, A A, Gilberto, D B, Jahansouz, H, Smith, G R, Tebben, A J, Liverton, N J, Selnick, H G, Claremon, D A, Billman, G E

“…To date, the lack of potent and selective inhibitors has hampered the physiological assessment of modulation of the cardiac slowly activating delayed rectifier…”
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An efficient synthesis of tetrasubstituted imidazoles from N-(2-Oxo)-amides by Claiborne, Christopher F., Liverton, Nigel J., Nguyen, Kevin T.

“…N-(2-Oxo)-amides were efficiently converted to tri- and tetra- substituted imidazoles under neutral reaction conditions upon treatment with neat ammonium…”
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NR2B-Selective N-Methyl-d-aspartate Antagonists:  Synthesis and Evaluation of 5-Substituted Benzimidazoles by McCauley, John A., Theberge, Cory R., Romano, Joseph J., Billings, Susan B., Anderson, Kenneth D., Claremon, David A., Freidinger, Roger M., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Connolly, Thomas M., Condra, Cindra L., Xia, Menghang, Cunningham, Michael E., Bednar, Bohumil, Stump, Gary L., Lynch, Joseph J., Macaulay, Alison, Wafford, Keith A., Koblan, Kenneth S., Liverton, Nigel J.

“…Two classes of 5-substituted benzimidazoles were identified as potent antagonists of the NR2B subtype of the N-methyl-d-aspartate (NMDA) receptor. Selected…”
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Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, IKs, in canine models of malignant ischemic ventricular arrhythmia by LYNCH, J. J, HOULE, M. S, CLAREMON, D. A, BILLMAN, G. E, STUMP, G. L, WALLACE, A. A, GILBERTO, D. B, JAHANSOUZ, H, SMITH, G. R, TEBBEN, A. J, LIVERTON, N. J, SELNICK, H. G

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Orally Efficacious NR2B-Selective NMDA Receptor Antagonists by Claiborne, Christopher F, McCauley, John A, Libby, Brian E, Curtis, Neil R, Diggle, Helen J, Kulagowski, Janusz J, Michelson, Stuart R, Anderson, Kenneth D, Claremon, David A, Freidinger, Roger M, Bednar, Rodney A, Mosser, Scott D, Gaul, Stanley L, Connolly, Thomas M, Condra, Cindra L, Bednar, Bohumil, Stump, Gary L, Lynch, Joseph J, Macaulay, Alison, Wafford, Keith A, Koblan, Kenneth S, Liverton, Nigel J

“…A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a…”
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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide by Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh

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Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux by Bednar, Bohumil, Cunningham, Michael E, Kiss, Laszlo, Cheng, Gong, McCauley, John A, Liverton, Nigel J, Koblan, Kenneth S

“…To facilitate the discovery of novel N-methyl- d-aspartate (NMDA) receptor antagonists, we have developed a high-throughput functional assay based on…”
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Pyridazine based inhibitors of p38 MAPK by McIntyre, Charles J, Ponticello, Gerald S, Liverton, Nigel J, O’Keefe, Stephen J, O’Neill, Edward A, Pang, Margaret, Schwartz, Cheryl D, Claremon, David A

“…Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38 MAPK. The most active isomers were those possessing an aryl group α and…”
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Antiarrhythmic Efficacy of Selective Blockade of the Cardiac Slowly Activating Delayed Rectifier Current, I Ks , in Canine Models of Malignant Ischemic Ventricular Arrhythmia by Lynch, Joseph J., Houle, Melanie S., Stump, Gary L., Wallace, Audrey A., Gilberto, David B., Jahansouz, Hossain, Smith, Garry R., Tebben, Andrew J., Liverton, Nigel J., Selnick, Harold G., Claremon, David A., Billman, George E.

“…Background —To date, the lack of potent and selective inhibitors has hampered the physiological assessment of modulation of the cardiac slowly activating…”
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Total synthesis of the latrunulins by SMITH, A. B, LEAHY, J. W, NODA, I, REMISZEWSKI, S. W, LIVERTON, N. J, ZIBUCK, R

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I Ks-blocking class III antiarrhythmic agents by Butcher, John W, Liverton, Nigel J, Claremon, David A, Freidinger, Roger M, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Wang, Jixin, Dieckhaus, Christine M, Slaughter, Donald E, Vyas, Kamlesh

“…Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones having various N-l substituents were identified as potent and selective blockers of the slowly activating cardiac…”
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Chemoselective Reactions of Amidines:  Selective Formation of Iminopyrimidine Regioisomers by McCauley, John A, Theberge, Cory R, Liverton, Nigel J

“…The dramatic effect of base on the chemoselectivity of the reaction of amidines with substituted 3-phenyl-2-propynylnitriles is demonstrated. Amidine 1 can be…”
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