Search Results - "Lively, Tracy"

Circulating Tumor DNA Assays in Clinical Cancer Research by Ossandon, Miguel R, Agrawal, Lokesh, Bernhard, Eric J, Conley, Barbara A, Dey, Sumana M, Divi, Rao L, Guan, Ping, Lively, Tracy G, McKee, Tawnya C, Sorg, Brian S, Tricoli, James V

“…The importance of circulating free DNA (cfDNA) in cancer clinical research was recognized in 1994 when a mutated RAS gene fragment was detected in a patient's…”
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Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration by McShane, Lisa M, Cavenagh, Margaret M, Lively, Tracy G, Eberhard, David A, Bigbee, William L, Williams, P Mickey, Mesirov, Jill P, Polley, Mei-Yin C, Kim, Kelly Y, Tricoli, James V, Taylor, Jeremy M G, Shuman, Deborah J, Simon, Richard M, Doroshow, James H, Conley, Barbara A

“…High-throughput 'omics' technologies that generate molecular profiles for biospecimens have been extensively used in preclinical studies to reveal molecular…”
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Criteria for the use of omics-based predictors in clinical trials by McShane, Lisa M., Cavenagh, Margaret M., Lively, Tracy G., Eberhard, David A., Bigbee, William L., Williams, P. Mickey, Mesirov, Jill P., Polley, Mei-Yin C., Kim, Kelly Y., Tricoli, James V., Taylor, Jeremy M. G., Shuman, Deborah J., Simon, Richard M., Doroshow, James H., Conley, Barbara A.

“…A checklist of criteria to determine the readiness of high-throughput ‘omics’-based tests for guiding patient therapy in clinical trials is discussed; the…”
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Biomarkers in early-phase trials: fundamental issues by Yee, Laura M, Lively, Tracy G, McShane, Lisa M

“…Biomarkers are frequently being included in early phase clinical trials. This article is meant to introduce clinical investigators to the fundamentals of…”
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A risk-management approach for effective integration of biomarkers in clinical trials: perspectives of an NCI, NCRI, and EORTC working group by Hall, Jacqueline Anne, Dr, Salgado, Roberto, MD, Lively, Tracy, PhD, Sweep, Fred, Prof, Schuh, Anna, MD

“…Summary Clinical cancer research today often includes testing the value of biomarkers to direct treatment and for drug development. However, the practical…”
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Bridging the Gap: Moving Predictive and Prognostic Assays from Research to Clinical Use by MICHAEL WILLIAMS, P, LIVELY, Tracy G, MILBURN JESSUP, J, CONLEY, Barbara A

“…The development of clinically useful molecular diagnostics requires validation of clinical assay performance and achievement of clinical qualification in…”
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The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution by Rood, Jennifer E., Coffey, Robert J., Demir, Emek, Ghosh, Sharmistha, Iacobuzio-Donahue, Christine A., Jané-Valbuena, Judit, Mazzilli, Sarah A., Pe’er, Dana, Tan, Kai, Aguilar, Ruben A., Babur, Ozgun, Boland, Genevieve, Bosse, Kristopher, Bott, Matthew, Boyden, Ed, Brooks, James, Cerami, Ethan, Chang, Young Hwan, Chaudhary, Ojasvi, Chen, Alyce A., Chen, Feng, Chun, Jaeyoung, Cisneros, Luis, Contrepois, Kevin, Creason, Allison L., Demir, Emek, Diskin, Sharon, Drewes, Julia, Eng, Jennifer, Erwin, Graham, Flaherty, Keith, Gao, Jianjiong, Gao, Vianne R., Giannakis, Marios, Gowers, Kate, Gray, Joe W., Greenleaf, William, Gresham, Jeremy, Hacohen, Nir, Harris, Kathleen A., Hayashi, Akimasa, Herndon, John M., Huh, Won Jae, Ijaz, Heba, Izar, Benjamin, Johnson, Brett E., Kaestner, Klaus, Kim, Albert H., Kopytra, Mateusz, Kundaje, Anshul, Lau, Ken S., Lee, Hayan, Lenburg, Marc, Lim, Kian-Huat, Lin, Yiyun, Lively, Tracy, Longabaugh, William J.R., Ma, Cynthia X., Marks, Jeffrey, Masilionais, Ignas, McKinley, Eliot T., McMichael, Joshua F., Mosse, Yael, Ness, Reid, Nikolov, Milen, Oberdoerffer, Philipp, Offin, Michael, Olson, Anastasiya, Ossandon, Miguel, Polyak, Kornelia, Reid, Mary, Roy, Sudipta, Ryser, Marc D., Schrag, Deborah, Sears, Rosalie C., Shalek, Alex, Sheng, Jeff, Shoghi, Kooresh I., Sibley, Alexander B., Sorger, Peter K., Southard-Smith, Austin, Srivastava, Sudhir, Storm, Phillip, Sullivan, Ryan, Suvà, Mario, Thorsson, Vésteinn, Tran, Linh, Veis, Deborah J., Vossough, Arastoo, Wagle, Nikhil, Wang, Liang-Bo, West, Robert, Wu, Chi-yun, Wyczalkowski, Matthew A., Xie, Yubin, Yang, Xiaolu, Zhang, Mianlei, Zhang, Yantian, Zhou, Daniel Cui, Zhuang, Xiaowei

“…Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and therapeutic resistance—involve complex interactions between cells…”
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Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer by Sparano, Joseph A, Gray, Robert J, Ravdin, Peter M, Makower, Della F, Pritchard, Kathleen I, Albain, Kathy S, Hayes, Daniel F, Geyer, Charles E, Dees, Elizabeth C, Goetz, Matthew P, Olson, John A, Lively, Tracy, Badve, Sunil S, Saphner, Thomas J, Wagner, Lynne I, Whelan, Timothy J, Ellis, Matthew J, Paik, Soonmyung, Wood, William C, Keane, Maccon M, Gomez Moreno, Henry L, Reddy, Pavan S, Goggins, Timothy F, Mayer, Ingrid A, Brufsky, Adam M, Toppmeyer, Deborah L, Kaklamani, Virginia G, Berenberg, Jeffrey L, Abrams, Jeffrey, Sledge, George W

“…TAILORx established the role of the 21-gene predictor of genetic risk in ascertaining treatment for women with hormone-receptor–positive, human epidermal…”
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Prospective Validation of a 21-Gene Expression Assay in Breast Cancer by Sparano, Joseph A, Gray, Robert J, Makower, Della F, Pritchard, Kathleen I, Albain, Kathy S, Hayes, Daniel F, Geyer, Charles E, Dees, Elizabeth C, Perez, Edith A, Olson, John A, Zujewski, JoAnne, Lively, Tracy, Badve, Sunil S, Saphner, Thomas J, Wagner, Lynne I, Whelan, Timothy J, Ellis, Matthew J, Paik, Soonmyung, Wood, William C, Ravdin, Peter, Keane, Maccon M, Gomez Moreno, Henry L, Reddy, Pavan S, Goggins, Timothy F, Mayer, Ingrid A, Brufsky, Adam M, Toppmeyer, Deborah L, Kaklamani, Virginia G, Atkins, James N, Berenberg, Jeffrey L, Sledge, George W

“…Patients with early-stage estrogen-receptor–positive, node-negative breast cancer whose 21-gene Oncotype DX profile suggested a low risk of recurrence were…”
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Program for the Assessment of Clinical Cancer Tests (PACCT): implementing promising assays into clinical practice by Jessup, J Milburn, Lively, Tracy G, Taube, Sheila E

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Race, Ethnicity, and Clinical Outcomes in Hormone Receptor-Positive, HER2-Negative, Node-Negative Breast Cancer in the Randomized TAILORx Trial by Albain, Kathy S, Gray, Robert J, Makower, Della F, Faghih, Amir, Hayes, Daniel F, Geyer, Charles E, Dees, Elizabeth C, Goetz, Matthew P, Olson, John A, Lively, Tracy, Badve, Sunil S, Saphner, Thomas J, Wagner, Lynne I, Whelan, Timothy J, Ellis, Matthew J, Wood, William C, Keane, Maccon M, Gomez, Henry L, Reddy, Pavan S, Goggins, Timothy F, Mayer, Ingrid A, Brufsky, Adam M, Toppmeyer, Deborah L, Kaklamani, Virginia G, Berenberg, Jeffrey L, Abrams, Jeffrey, Sledge, George W, Sparano, Joseph A

“…Abstract Background Black race is associated with worse outcomes in early breast cancer. We evaluated clinicopathologic characteristics, the 21-gene recurrence…”
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Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group by Dowsett, Mitch, Nielsen, Torsten O., A'Hern, Roger, Bartlett, John, Coombes, R. Charles, Cuzick, Jack, Ellis, Matthew, Henry, N. Lynn, Hugh, Judith C., Lively, Tracy, McShane, Lisa, Paik, Soon, Penault-Llorca, Frederique, Prudkin, Ljudmila, Regan, Meredith, Salter, Janine, Sotiriou, Christos, Smith, Ian E., Viale, Giuseppe, Zujewski, Jo Anne, Hayes, Daniel F.

“…Uncontrolled proliferation is a hallmark of cancer. In breast cancer, immunohistochemical assessment of the proportion of cells staining for the nuclear…”
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Cancer diagnostics: decision criteria for marker utilization in the clinic by Taube, Sheila E, Jacobson, James W, Lively, Tracy G

“…A new diagnostic tool must pass three major tests before it is adopted for routine clinical use. First, the tool must be robust and reproducible; second, the…”
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Steps forward for cancer precision medicine by Salgado, Roberto, Moore, Helen, Martens, John W. M., Lively, Tracy, Malik, Shakun, McDermott, Ultan, Michiels, Stefan, Moscow, Jeffrey A., Tejpar, Sabine, McKee, Tawnya, Lacombe, Denis

“…The availability of targeted anticancer drugs and the relative affordability of genomic analyses has led to a growing expectation among patients with cancer…”
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Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study by Jacobson, James W, Beer, David G, Shedden, Kerby, Taylor, Jeremy M G, Enkemann, Steven A, Tsao, Ming-Sound, Yeatman, Timothy J, Gerald, William L, Eschrich, Steven, Jurisica, Igor, Giordano, Thomas J, Misek, David E, Chang, Andrew C, Zhu, Chang Qi, Strumpf, Daniel, Hanash, Samir, Shepherd, Frances A, Ding, Keyue, Seymour, Lesley, Naoki, Katsuhiko, Pennell, Nathan, Weir, Barbara, Verhaak, Roel, Ladd-Acosta, Christine, Golub, Todd, Gruidl, Michael, Sharma, Anupama, Szoke, Janos, Zakowski, Maureen, Rusch, Valerie, Kris, Mark, Viale, Agnes, Motoi, Noriko, Travis, William, Conley, Barbara, Seshan, Venkatraman E, Meyerson, Matthew, Kuick, Rork, Dobbin, Kevin K, Lively, Tracy

“…Studies of gene expression in lung cancer have the potential to affect patient care, but the general applicability of the derived classifiers is unclear. David…”
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Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial by Sparano, Joseph A, Gray, Robert J, Makower, Della F, Albain, Kathy S, Saphner, Thomas J, Badve, Sunil S, Wagner, Lynne I, Kaklamani, Virginia G, Keane, Maccon M, Gomez, Henry L, Reddy, Pavan S, Goggins, Timothy F, Mayer, Ingrid A, Toppmeyer, Deborah L, Brufsky, Adam M, Goetz, Matthew P, Berenberg, Jeffrey L, Mahalcioiu, Catalin, Desbiens, Christine, Hayes, Daniel F, Dees, Elizabeth C, Geyer, Jr, Charles E, Olson, Jr, John A, Wood, William C, Lively, Tracy, Paik, Soonmyung, Ellis, Matthew J, Abrams, Jeffrey, Sledge, Jr, George W

“…A high 21-gene recurrence score (RS) by breast cancer assay is prognostic for distant recurrence of early breast cancer after local therapy and endocrine…”
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57. Curating variants of established clinical significance by Khanfar, Mariam, Danos, Arpad, Saliba, Jason, Kovach, Alexandra E., Grisdale, Cameron J., Mullighan, Charles, Kesserwan, Chimene, King, Ian, Merker, Jason, Satgunaseelan, Laveniya Satgunaseelan, Kanagal-Shamanna, Rashmi, Lively, Tracy, Govindan, Ramaswamy, Griffith, Malachi, Akkari, Yassmine, Griffith, Obi

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16. ClinGen Cancer Variant Interpretation (CVI) Committee: Pilot guidance for somatic cancer variant curation expert panels by Ritter, Deborah, Duncavage, Eric, Elvin, Julia, Frampton, Garrett, Pavlick, Dean, Griffith, Obi, Griffith, Malachi, Janeway, Katherine, Lively, Tracy, Macconaill, Laura, McCoy, Matthew, Meric-Bernstam, Funda, Merker, Jason, Mullighan, Charles G., Parsons, Donald (Will), Patel, Keyur, Raca, Gordana, Ramos, Erin, Rosenbaum, Jason, Roy, Somak, Roy, Angshumoy, Seifi, Morteza, Sonkin, Dmitriy, Wagner, Alex, Warner, Jeremy, Plon, Sharon, Li, Marilyn, Kulkarni, Shashikant

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94. Initial efforts of the ClinGen Solid Tumor Taskforce in promoting variant curation in solid tumors into CIViC by Satgunaseelan, Laveniya, Sukhanova, Madina, Toruner, Gokce, Danos, Arpad, Allen, Destiney, Akesson, Lauren, Corson, Laura, Farzanmehr, Haleh, Gonzalez, Ariana, Grisdale, Cameron, Kavus, Haluk, Li, Yuwen, Lively, Tracy, Melas, Marilena, Merker, Jason, Rao, Mamta, Selvarajah, Shamini, Shi, Zonggao, Sonkin, Dmitriy, Spiteri, Elizabeth, Williams, Heather, Zhao, Xiaonan, Zhong, Yiming, Saliba, Jason, Griffith, Obi, Griffith, Malachi, King, Ian

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Impact of clinical risk category on prognosis and prediction of chemotherapy benefit in early breast cancer (EBC) by age and the 21-gene recurrence score (RS) in TAILORx by Sparano, Joseph A., Gray, Robert James, Makower, Della F., Lively, Tracy G., Saphner, Thomas James, Keane, Maccon M., Gomez, Henry Leonidas, Reddy, Pavan S., Goggins, Timothy F., Mayer, Ingrid A., Toppmeyer, Deborah, Brufsky, Adam, Goetz, Matthew P., Hayes, Daniel F., Dees, Elizabeth Claire, Pritchard, Kathleen I., Geyer, Charles E., Olson, John A., Albain, Kathy S., Sledge, George W.

“…Abstract only 503 Background: TAILORx established that endocrine therapy (ET) alone is non-inferior to adjuvant chemotherapy (CT) plus ET in EBC and a 21-gene…”
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