Search Results - "Liu, Zongliang"

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review by Dai, Jinlian, Tian, Sen, Yang, Xueqing, Liu, Zongliang

“…Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole…”
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Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy? by Chen, Tingkai, Li, Qi, Liu, Zongliang, Chen, Yao, Feng, Feng, Sun, Haopeng

“…Blockade the interaction of the programmed cell death protein 1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1) can prevent immune evasion of tumor…”
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Alzheimer's Disease and Cancer: Common Targets by Yang, Xueqing, Dai, Jinlian, Wu, Chenglong, Liu, Zongliang

“…There is growing epidemiologic evidence of an inverse association between cancer and AD. In addition, both cell survival and death are regulated by the same…”
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Multi-Target Drug Design of Anti-Alzheimer's Disease based on Tacrine by Tian, Sen, Huang, Zhongwei, Meng, Qingguo, Liu, Zongliang

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease with concealed onset, which is characterized by the damage of the cholinergic system,…”
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Translocation of probiotics via gut–lung axis enhanced pulmonary immunity of weaned piglets exposed to low concentrations of ammonia by Yang, Jiajun, Wang, Jing, Shang, Peng, Liu, Zongliang, Zhang, Bo, Yang, Dongsheng, Zhang, Hao

“…Lactobacillus salivarius is a probiotic bacteria strain in human and animal diets. The administration of probiotics to weaned piglets may improve their growth…”
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Ligilactobacillus Salivarius improve body growth and anti-oxidation capacity of broiler chickens via regulation of the microbiota-gut-brain axis by Yang, Jiajun, Wang, Jing, Liu, Zongliang, Chen, Jun, Jiang, Jiajing, Zhao, Minmeng, Gong, Daoqing

“…Certain strains of probiotic bacteria can secret functional substances namely digestive enzymes and functional peptides to regulate physiological conditions…”
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Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer by Liu, Zongliang, Yu, Pengfei, Dong, Lin, Wang, Wenyan, Duan, Sijin, Wang, Bingsi, Gong, Xiaoyan, Ye, Liang, Wang, Hongbo, Tian, Jingwei

“…The neurotrophic receptor tyrosine kinase (NTRK) genes including NTRK1, NTRK2, and NTRK3 encode the tropomyosin receptor kinase (Trk) proteins TrkA, TrkB, and…”
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Synthesis, Characterization, and Anticancer Activities Evaluation of Compounds Derived from 3,4-Dihydropyrimidin-2(1 H )-one by Liu, Ye, Liu, Jiaqi, Zhang, Renmei, Guo, Yan, Wang, Hongbo, Meng, Qingguo, Sun, Yuan, Liu, Zongliang

“…3,4-dihydropyrimidin-2(1 )-one compounds (DHPMs) possess extensive biological activities and are mainly prepared via Biginelli reaction and N-alkylation. In…”
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Combined Use of Bacillus subtilis yb-114,246 and Bacillus licheniformis yb-214,245 Improves Body Growth Performance of Chinese Huainan Partridge Shank Chickens by Enhancing Intestinal Digestive Profiles by Yang, Jiajun, Huang, Kehe, Wang, Jing, Wu, Dong, Liu, Zongliang, Yu, Pengcheng, Wei, Zhanyong, Chen, Fu

“…The aim of our study was to unveil the promoting function of compound Bacillus sp. in improving chicken digestion-induced higher body growth performance…”
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PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo by Li, Fangfang, Liu, Zongliang, Sun, Heyuan, Li, Chunmei, Wang, Wenyan, Ye, Liang, Yan, Chunhong, Tian, Jingwei, Wang, Hongbo

“…Gliomas are the most common primary intracranial neoplasms among all brain malignancies, and the microtubule affinity regulating kinases (MARKs) have become…”
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Phase 1 clinical trial of the PI3Kδ inhibitor YY-20394 in patients with B-cell hematological malignancies by Jiang, Bo, Qi, Junyuan, Song, Yuqin, Li, Zengjun, Tu, Meifeng, Ping, Lingyan, Liu, Zongliang, Bao, Hanying, Xu, Zusheng, Qiu, Lugui

“…Abstract YY-20394, an oral phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor, was investigated in a first-in-human study of patients with relapsed or…”
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Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases by Guo, Yan, Yang, Hongyu, Huang, Zhongwei, Tian, Sen, Li, Qihang, Du, Chenxi, Chen, Tingkai, Liu, Yang, Sun, Haopeng, Liu, Zongliang

“…A series of novel compounds - , - , - , and - were synthesized and evaluated, together with the known analogs - , for their inhibitory activities towards…”
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Anti-Colorectal Cancer Effects of a Novel Camptothecin Derivative PCC0208037 In Vitro and In Vivo by Li, Min, Wang, Linxu, Wei, Yingjie, Wang, Wenyan, Liu, Zongliang, Zuo, Aixia, Liu, Wanhui, Tian, Jingwei, Wang, Hongbo

“…Colorectal cancer is one of the most common malignancies, and the topoisomerase inhibitor irinotecan (CPT-11)-based chemotherapeutic regimen is currently the…”
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Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease by Mo, Jun, Chen, Tingkai, Yang, Hongyu, Guo, Yan, Li, Qi, Qiao, Yuting, Lin, Hongzhi, Feng, Feng, Liu, Wenyuan, Chen, Yao, Liu, Zongliang, Sun, Haopeng

“…Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer's disease (AD). Herein, we report the medicinal chemistry efforts…”
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Risk of development of acute pancreatitis with pre-existing diabetes: a meta-analysis by Xue, Yuzheng, Sheng, Yingyue, Dai, Hong, Cao, Haiyan, Liu, Zongliang, Li, Zhaoshen

“…OBJECTIVESIt is well established that acute pancreatitis (AP) often causes diabetes mellitus. However, whether pre-existing diabetes is associated with the…”
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Discovery and Design of Tricyclic Scaffolds as Protein Kinase CK2 (CK2) Inhibitors through a Combination of Shape-Based Virtual Screening and Structure-Based Molecular Modification by Sun, Haopeng, Xu, Xiaoli, Wu, Xiaowen, Zhang, Xiaojin, Liu, Fang, Jia, Jianmin, Guo, Xiaoke, Huang, Jingjie, Jiang, Zhengyu, Feng, Taotao, Chu, Hongxi, Zhou, You, Zhang, Shenglie, Liu, Zongliang, You, Qidong

“…Protein kinase CK2 (CK2), a ubiquitous serine/threonine protein kinase for hundreds of endogenous substrates, serves as an attractive anticancer target. One of…”
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Dual pH-responsive and CD44 receptor targeted multifunctional nanoparticles for anticancer intracellular delivery by Chen, Daquan, Sun, Jingfang, Lian, Shengnan, Liu, Zongliang, Sun, Kaoxiang, Liu, Wanhui, Wu, Zimei, Zhang, Qiang

“…In this article, we prepared a multifunctional oligosaccharides of hyaluronan (oHA) conjugates, oHA-histidine-menthone 1,2-glycerol ketal (oHM). The oHM…”
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Discovery of novel CK2 leads by cross-docking based virtual screening by Sun, Haopeng, Wu, Xiaowen, Xu, Xiaoli, Jiang, Zhengyu, Liu, Zongliang, You, Qidong

“…Protein kinase CK2, a serine/threonine kinase, is an attractive therapeutic target for many diseases. Here we described an application of cross-docking based…”
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Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid by Luan, Mingzhu, Wang, Huiyun, Wang, Jiazhen, Zhang, Xiaofan, Zhao, Fenglan, Liu, Zongliang, Meng, Qingguo

“…In vivo and in vitro studies reveal that Ursolic Acid (UA) is able to counteract endogenous and exogenous inflammatory stimuli and has favorable…”
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Improved surface morphology and reduced V-pits density of lattice-matched AlInN films grown by atmospheric pressure metalorganic chemical vapor deposition by Fan, Shaosheng, Ikeda, Masao, Zhang, Baoping, Li, Zenglin, Su, Xujun, Liu, Zongliang, Xu, Ke

“…AlInN has emerged as a promising material for advanced optoelectronic and electronic devices due to its unique properties. However, achieving AlInN layers with…”
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