Search Results - "Liu, Zihe"
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A gRNA-tRNA array for CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces cerevisiae
Published in Nature communications (05-03-2019)“…With rapid progress in DNA synthesis and sequencing, strain engineering starts to be the rate-limiting step in synthetic biology. Here, we report a gRNA-tRNA…”
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Review on Cyber-physical Systems
Published in IEEE/CAA journal of automatica sinica (2017)“…Cyber-physical systems(CPS) are complex systems with organic integration and in-depth collaboration of computation, communications and control(3C) technology…”
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Third-generation biorefineries as the means to produce fuels and chemicals from CO2
Published in Nature catalysis (18-03-2020)“…Concerns regarding petroleum depletion and global climate change caused by greenhouse gas emissions have spurred interest in renewable alternatives to fossil…”
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4
Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing
Published in Scientific reports (17-08-2020)“…With the growth of metabolomics research, more and more studies are conducted on large numbers of samples. Due to technical limitations of the Liquid…”
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Morphological trait as a determining factor for Populus simonii Carr. to survive from drought in semi-arid region
Published in Agricultural water management (01-07-2021)“…Widespread tree mortality induced by drought events causes significant damage to the local ecosystem and society. Populus simonii Carr. in Zhangbei, Bashang…”
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High-throughput screening for industrial enzyme production hosts by droplet microfluidics
Published in Lab on a chip (01-01-2014)“…A high-throughput method for single cell screening by microfluidic droplet sorting is applied to a whole-genome mutated yeast cell library yielding improved…”
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Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae
Published in Scientific reports (10-05-2016)“…n -Butanol has several favourable properties as an advanced fuel or a platform chemical. Bio-based production of n -butanol is becoming increasingly important…”
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A Multimodal Approach for Multiple-Relation Extraction in Videos
Published in Multimedia tools and applications (01-02-2022)“…Automatically interpreting social relations, e.g., friendship, kinship, etc., from visual scenes has huge potential application value in areas such as…”
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Expressing a cytosolic pyruvate dehydrogenase complex to increase free fatty acid production in Saccharomyces cerevisiae
Published in Microbial cell factories (10-12-2020)“…Saccharomyces cerevisiae is being exploited as a cell factory to produce fatty acids and their derivatives as biofuels. Previous studies found that both…”
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Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast
Published in Proceedings of the National Academy of Sciences - PNAS (25-08-2015)“…There is an increasing demand for biotech-based production of recombinant proteins for use as pharmaceuticals in the food and feed industry and in industrial…”
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A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi
Published in Nature communications (17-07-2023)“…Synthetic biology requires efficient systems that support the well-coordinated co-expression of multiple genes. Here, we discover a 9-bp nucleotide sequence…”
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Mechanistic basis for the allosteric activation of NADase activity in the Sir2-HerA antiphage defense system
Published in Nature communications (27-10-2024)“…Sir2-HerA is a widely distributed antiphage system composed of a RecA-like ATPase (HerA) and an effector with potential NADase activity (Sir2). Sir2-HerA is…”
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Increased CO2 fixation enables high carbon-yield production of 3-hydroxypropionic acid in yeast
Published in Nature communications (21-02-2024)“…CO 2 fixation plays a key role to make biobased production cost competitive. Here, we use 3-hydroxypropionic acid (3-HP) to showcase how CO 2 fixation enables…”
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Structural basis of ubiquitin modification by the Legionella effector SdeA
Published in Nature (London) (01-05-2018)“…Protein ubiquitination is a multifaceted post-translational modification that controls almost every process in eukaryotic cells. Recently, the Legionella…”
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Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae
Published in Metabolic engineering (01-03-2012)“…The yeast Saccharomyces cerevisiae is a widely used platform for the production of heterologous proteins of medical or industrial interest. However,…”
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Synthetic Biology Advanced Natural Product Discovery
Published in Metabolites (17-11-2021)“…A wide variety of bacteria, fungi and plants can produce bioactive secondary metabolites, which are often referred to as natural products. With the rapid…”
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Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila
Published in Nature communications (26-07-2022)“…Toxin-antitoxin (TA) systems are ubiquitous genetic modules in bacteria and archaea. Here, we perform structural and biochemical characterization of the…”
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Water Storage and Use by Platycladus orientalis under Different Rainfall Conditions in the Rocky Mountainous Area of Northern China
Published in Forests (01-11-2022)“…Tree water transport and utilization are essential for maintaining ecosystem stability in seasonally arid areas. However, it is not clear how Platycladus…”
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Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae
Published in FEMS yeast research (01-08-2012)“…Abstract The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels and chemicals, and it is also provides a platform for the…”
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Bioprospecting Through Cloning of Whole Natural Product Biosynthetic Gene Clusters
Published in Frontiers in bioengineering and biotechnology (05-06-2020)“…Since the discovery of penicillin, natural products and their derivatives have been a valuable resource for drug discovery. With recent development of genome…”
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