Search Results - "Liu, Zhida"

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis by Rao, Lang, Wu, Lei, Liu, Zhida, Tian, Rui, Yu, Guocan, Zhou, Zijian, Yang, Kuikun, Xiong, Hong-Gang, Zhang, Anli, Yu, Guang-Tao, Sun, Wenjing, Xu, Han, Guo, Jingya, Li, Andrew, Chen, Hongmin, Sun, Zhi-Jun, Fu, Yang-Xin, Chen, Xiaoyuan

“…Effectively activating macrophages against cancer is promising but challenging. In particular, cancer cells express CD47, a ‘don’t eat me’ signal that…”
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A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy by Hsu, Eric J., Cao, Xuezhi, Moon, Benjamin, Bae, Joonbeom, Sun, Zhichen, Liu, Zhida, Fu, Yang-Xin

“…As a potent lymphocyte activator, interleukin-2 (IL-2) is an FDA-approved treatment for multiple metastatic cancers. However, its clinical use is limited by…”
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A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control by Sun, Zhichen, Ren, Zhenhua, Yang, Kaiting, Liu, Zhida, Cao, Shuaishuai, Deng, Sisi, Xu, Lily, Liang, Yong, Guo, Jingya, Bian, Yingjie, Xu, Hairong, Shi, Jiyun, Wang, Fan, Fu, Yang-Xin, Peng, Hua

“…While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity, and propensity to amplify Treg cells are major barriers…”
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Targeting innate sensing in the tumor microenvironment to improve immunotherapy by Liu, Zhida, Han, Chuanhui, Fu, Yang-Xin

“…The innate immune sensing pathways play critical roles in the defense against pathogen infection, but their roles in cancer immunosurveillance and cancer…”
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Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity by Feng, Qiang, Liu, Zhida, Yu, Xuexin, Huang, Tongyi, Chen, Jiahui, Wang, Jian, Wilhelm, Jonathan, Li, Suxin, Song, Jiwon, Li, Wei, Sun, Zhichen, Sumer, Baran D., Li, Bo, Fu, Yang-Xin, Gao, Jinming

“…Lactate is a key metabolite produced from glycolytic metabolism of glucose molecules, yet it also serves as a primary carbon fuel source for many cell types…”
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Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling by Han, Chuanhui, Liu, Zhida, Zhang, Yunjia, Shen, Aijun, Dong, Chunbo, Zhang, Anli, Moore, Casey, Ren, Zhenhua, Lu, Changzheng, Cao, Xuezhi, Zhang, Chun-Li, Qiao, Jian, Fu, Yang-Xin

“…High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA…”
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Chemotherapy Induces Cancer-Fighting B Cells by Liu, Zhida, Fu, Yang-Xin

“…Tumor-infiltrating B cells are heterogeneous, and their roles in tumor immunity are controversial. In this issue of Cell, Lu and colleagues demonstrate that…”
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity by Lu, Changzheng, Guan, Junhong, Lu, Steve, Jin, Qihuang, Rousseau, Benoit, Lu, Tianshi, Stephens, Dennis, Zhang, Hongyi, Zhu, Jiankun, Yang, Mingming, Ren, Zhenhua, Liang, Yong, Liu, Zhida, Han, Chuanhui, Liu, Longchao, Cao, Xuezhi, Zhang, Anli, Qiao, Jian, Batten, Kimberly, Chen, Mingyi, Castrillon, Diego H., Wang, Tao, Li, Bo, Diaz, Luis A., Li, Guo-Min, Fu, Yang-Xin

“…Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR) are proposed as the major contributor to the high objective response…”
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NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance by Li, Xiaoguang, Liu, Zhida, Zhang, Anli, Han, Chuanhui, Shen, Aijun, Jiang, Lingxiang, Boothman, David A., Qiao, Jian, Wang, Yang, Huang, Xiumei, Fu, Yang-Xin

“…Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly…”
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Small molecular drugs reshape tumor microenvironment to synergize with immunotherapy by Han, Chuanhui, Zhang, Anli, Liu, Zhida, Moore, Casey, Fu, Yang-Xin

“…Recently, immune checkpoint blockade (ICB), especially anti-programmed death 1 (anti-PD-1) and anti-programmed death-ligand 1 (anti-PD-L1) therapy, has become…”
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A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response by Fermaintt, Charles S., Sano, Kanae, Liu, Zhida, Ishii, Nozomi, Seino, Junichi, Dobbs, Nicole, Suzuki, Tadashi, Fu, Yang-Xin, Lehrman, Mark A., Matsuo, Ichiro, Yan, Nan

“…Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about…”
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The critical control of arkosic sandstone porosity on deformation band formation: Insights from the Shulu across-fault borehole in the Bohai Bay Basin, China by Liu, Zhida, Fu, Xiaofei, Deng, Shang, Meng, Lingdong, Wang, Haixue, Sun, Yonghe, Chen, Zaihe

“…Fewer studies have focused on subsurface deformation bands than deformation bands in outcrops. In this work, we studied the subsurface deformation bands in…”
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A novel method for synthetic vaccine construction based on protein assembly by Liu, Zhida, Zhou, Hang, Wang, Wenjun, Tan, Wenjie, Fu, Yang-Xin, Zhu, Mingzhao

“…In the history of vaccine development, the synthetic vaccine is a milestone that is in stark contrast with traditional vaccines based on live-attenuated or…”
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CTLA-4 Limits Anti-CD20-Mediated Tumor Regression by Ren, Zhenhua, Guo, Jingya, Liao, Jing, Luan, Yan, Liu, Zhida, Sun, Zhichen, Liu, Xiaojuan, Liang, Yong, Peng, Hua, Fu, Yang-Xin

“…The inhibition of tumor growth by anti-CD20 antibody (Ab) treatment is mediated by Ab- and complement-dependent cytotoxicity in xenograft tumor models. In…”
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Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles by Gao, Xiaofei, Zhang, Zhaohuan, Mashimo, Tomoyuki, Shen, Bo, Nyagilo, James, Wang, Hao, Wang, Yihui, Liu, Zhida, Mulgaonkar, Aditi, Hu, Xiao-Ling, Piccirillo, Sara G.M., Eskiocak, Ugur, Davé, Digant P., Qin, Song, Yang, Yongjie, Sun, Xiankai, Fu, Yang-Xin, Zong, Hui, Sun, Wenzhi, Bachoo, Robert M., Ge, Woo-ping

“…Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal…”
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A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection by Tai, Wanbo, Yang, Kai, Liu, Yubin, Li, Ruofan, Feng, Shengyong, Chai, Benjie, Zhuang, Xinyu, Qi, Shaolong, Shi, Huicheng, Liu, Zhida, Lei, Jiaqi, Ma, Enhao, Wang, Weixiao, Tian, Chongyu, Le, Ting, Wang, Jinyong, Chen, Yunfeng, Tian, Mingyao, Xiang, Ye, Yu, Guocan, Cheng, Gong

“…The respiratory system, especially the lung, is the key site of pathological injury induced by SARS-CoV-2 infection. Given the low feasibility of targeted…”
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Author Correction: A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control by Sun, Zhichen, Ren, Zhenhua, Yang, Kaiting, Liu, Zhida, Cao, Shuaishuai, Deng, Sisi, Xu, Lily, Liang, Yong, Guo, Jingya, Bian, Yingjie, Xu, Hairong, Shi, Jiyun, Wang, Fan, Fu, Yang-Xin, Peng, Hua

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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An innovative model fusion algorithm to improve the recall rate of peer-to-peer lending default customers by Liu, Zhida, Zhang, Zhenyu, Yang, Hongwei, Wang, Guoqiang, Xu, Zhenwei

“…Peer-to-peer (P2P) lending is a fintech innovation that provides loans to individuals and businesses without the need for additional intermediaries. However,…”
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Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy by Jiang, Xiaoyi, Wang, Jian, Zheng, Xichen, Liu, Zhida, Zhang, Xinyu, Li, Yuwei, Wilhelm, Jonathan, Cao, Jun, Huang, Gang, Zhang, Jinlan, Sumer, Baran, Lea, Jayanthi, Lu, Zhigang, Gao, Jinming, Luo, Min

“…BackgroundCancer vaccines are able to achieve tumor-specific immune editing in early-phase clinical trials. However, the infiltration of cytotoxic T cells into…”
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Downregulation of microRNA‑30a in bronchoalveolar lavage fluid from idiopathic pulmonary fibrosis patients by Liu, Bao, Jiang, Tingshu, Hu, Xingang, Liu, Zhida, Zhao, Liming, Liu, Hongmei, Liu, Zhaihua, Ma, Lijun

“…MicroRNAs (miRs) are short, highly conserved small noncoding RNA molecules with fundamental roles in regulating gene expression. To identify miR biomarkers…”
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