Search Results - "Liu, V"

Refining the treatment of NSCLC according to histological and molecular subtypes by Thomas, Anish, Liu, Stephen V., Subramaniam, Deepa S., Giaccone, Giuseppe

“…Key Points Our understanding of non-small-cell lung cancer (NSCLC) has evolved from a single disease entity that was treated with a one-size-fits-all approach…”
Get full text

FDG-PET response and outcome from anti-PD-1 therapy in metastatic melanoma by Tan, A.C., Emmett, L., Lo, S., Liu, V., Kapoor, R., Carlino, M.S., Guminski, A.D., Long, G.V., Menzies, A.M.

“…Immune checkpoint inhibitor therapy has resulted in impressive and durable clinical activity for many cancers including melanoma; however, there remain few…”
Get full text

Pembrolizumab for Platinum- and Cetuximab-Refractory Head and Neck Cancer: Results From a Single-Arm, Phase II Study by Bauml, Joshua, Seiwert, Tanguy Y, Pfister, David G, Worden, Francis, Liu, Stephen V, Gilbert, Jill, Saba, Nabil F, Weiss, Jared, Wirth, Lori, Sukari, Ammar, Kang, Hyunseok, Gibson, Michael K, Massarelli, Erminia, Powell, Steven, Meister, Amy, Shu, Xinxin, Cheng, Jonathan D, Haddad, Robert

“…Purpose There are no approved treatments for recurrent/metastatic head and neck squamous cell carcinoma refractory to platinum and cetuximab. In the…”
Get full text

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer by Horn, Leora, Mansfield, Aaron S, Szczęsna, Aleksandra, Havel, Libor, Krzakowski, Maciej, Hochmair, Maximilian J, Huemer, Florian, Losonczy, György, Johnson, Melissa L, Nishio, Makoto, Reck, Martin, Mok, Tony, Lam, Sivuonthanh, Shames, David S, Liu, Juan, Ding, Beiying, Lopez-Chavez, Ariel, Kabbinavar, Fairooz, Lin, Wei, Sandler, Alan, Liu, Stephen V

“…In a randomized trial, the addition of atezolizumab to carboplatin and etoposide resulted in significantly longer overall survival than carboplatin and…”
Get full text

Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study by Gainor, Justin F, Curigliano, Giuseppe, Kim, Dong-Wan, Lee, Dae Ho, Besse, Benjamin, Baik, Christina S, Doebele, Robert C, Cassier, Philippe A, Lopes, Gilberto, Tan, Daniel S W, Garralda, Elena, Paz-Ares, Luis G, Cho, Byoung Chul, Gadgeel, Shirish M, Thomas, Michael, Liu, Stephen V, Taylor, Matthew H, Mansfield, Aaron S, Zhu, Viola W, Clifford, Corinne, Zhang, Hui, Palmer, Michael, Green, Jennifer, Turner, Christopher D, Subbiah, Vivek

“…Oncogenic alterations in RET have been identified in multiple tumour types, including 1–2% of non-small-cell lung cancers (NSCLCs). We aimed to assess the…”
Get full text

Drugging KRAS: current perspectives and state-of-art review by Parikh, Kaushal, Banna, Giuseppe, Liu, Stephen V., Friedlaender, Alex, Desai, Aakash, Subbiah, Vivek, Addeo, Alfredo

“…Abstract After decades of efforts, we have recently made progress into targeting KRAS mutations in several malignancies. Known as the ‘holy grail’ of targeted…”
Get full text

Addressing challenges with real-world synthetic control arms to demonstrate the comparative effectiveness of Pralsetinib in non-small cell lung cancer by Popat, Sanjay, Liu, Stephen V., Scheuer, Nicolas, Hsu, Grace G., Lockhart, Alexandre, Ramagopalan, Sreeram V., Griesinger, Frank, Subbiah, Vivek

“…As advanced non-small cell lung cancer (aNSCLC) is being increasingly divided into rare oncogene-driven subsets, conducting randomised trials becomes…”
Get full text

Geometric and Electronic Structure Contributions to Function in Non-heme Iron Enzymes by Solomon, Edward I, Light, Kenneth M, Liu, Lei V, Srnec, Martin, Wong, Shaun D

“…Mononuclear non-heme Fe (NHFe) enzymes play key roles in DNA repair, the biosynthesis of antibiotics, the response to hypoxia, cancer therapy, and many other…”
Get full text

Characterization of KRAS Mutation Subtypes in Non-small Cell Lung Cancer by Judd, Julia, Abdel Karim, Nagla, Khan, Hina, Naqash, Abdul Rafeh, Baca, Yasmine, Xiu, Joanne, VanderWalde, Ari M, Mamdani, Hirva, Raez, Luis E, Nagasaka, Misako, Pai, Sachin Gopalkrishna, Socinski, Mark A, Nieva, Jorge J, Kim, Chul, Wozniak, Antoinette J, Ikpeazu, Chukwuemeka, de Lima Lopes, Jr, Gilberto, Spira, Alexander I, Korn, W Michael, Kim, Edward S, Liu, Stephen V, Borghaei, Hossein

“…is the most commonly mutated oncogene in NSCLC and development of direct KRAS inhibitors has renewed interest in this molecular variant. Different mutations…”
Get full text

Validation of the Decipher genomic classifier in patients receiving salvage radiotherapy without hormone therapy after radical prostatectomy – an ancillary study of the SAKK 09/10 randomized clinical trial by Dal Pra, A., Ghadjar, P., Hayoz, S., Liu, V.Y.T., Spratt, D.E., Thompson, D.J.S., Davicioni, E., Huang, H.-C., Zhao, X., Liu, Y., Schär, C., Gut, P., Plasswilm, L., Hölscher, T., Polat, B., Hildebrandt, G., Müller, A.-C., Pollack, A., Thalmann, G.N., Zwahlen, D., Aebersold, D.M.

“…The Decipher genomic classifier (GC) has shown to independently prognosticate outcomes in prostate cancer. The objective of this study was to validate the GC…”
Get full text

Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes by Estrada-Bernal, Adriana, Le, Anh T, Doak, Andrea E, Tirunagaru, Vijaya G, Silva, Shevan, Bull, Matthew R, Smaill, Jeff B, Patterson, Adam V, Kim, Chul, Liu, Stephen V, Doebele, Robert C

“…Approved therapies for exon 20, mutations, and fusions are currently lacking for non-small cell lung cancer and other cancers. Tarloxotinib is a prodrug that…”
Get full text

Structure and reactivity of a mononuclear non-haem iron(III)–peroxo complex by Cho, Jaeheung, Jeon, Sujin, Wilson, Samuel A., Liu, Lei V., Kang, Eun A., Braymer, Joseph J., Lim, Mi Hee, Hedman, Britt, Hodgson, Keith O., Valentine, Joan Selverstone, Solomon, Edward I., Nam, Wonwoo

“…Iron–oxygen intermediates identified The iron–oxygen species iron( III )-peroxo, iron( III )-hydroperoxo and iron( IV )-oxo are key intermediates often…”
Get full text

Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer by Kim, In-Kyu, McCutcheon, Justine N., Rao, Guanhua, Liu, Stephen V., Pommier, Yves, Skrzypski, Marcin, Zhang, Yu-Wen, Giaccone, Giuseppe

“…Resistance to chemotherapy remains a critical barrier to effective cancer treatment. Although cisplatin is one of the most commonly used chemotherapeutic…”
Get full text

A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105 by Drilon, Alexander, Fu, Siqing, Patel, Manish R, Fakih, Marwan, Wang, Ding, Olszanski, Anthony J, Morgensztern, Daniel, Liu, Stephen V, Cho, Byoung Chul, Bazhenova, Lyudmila, Rodriguez, Cristina P, Doebele, Robert C, Wozniak, Antoinette, Reckamp, Karen L, Seery, Tara, Nikolinakos, Petros, Hu, Zheyi, Oliver, Jennifer W, Trone, Denise, McArthur, Katherine, Patel, Rupal, Multani, Pratik S, Ahn, Myung-Ju

“…fusions are oncogenic drivers of various tumors, including non-small cell lung cancers (NSCLC). The safety and antitumor activity of the multikinase RET…”
Get more information

Comparison of High-Spin and Low-Spin Nonheme FeIII–OOH Complexes in O–O Bond Homolysis and H‑Atom Abstraction Reactivities by Liu, Lei V, Hong, Seungwoo, Cho, Jaeheung, Nam, Wonwoo, Solomon, Edward I

“…The geometric and electronic structures and reactivity of an S = 5/2 (HS) mononuclear nonheme (TMC)FeIII–OOH complex are studied by spectroscopies,…”
Get full text

Safety and efficacy of immune checkpoint inhibitors (ICIs) in cancer patients with HIV, hepatitis B, or hepatitis C viral infection by Shah, Neil J., Al-Shbool, Ghassan, Blackburn, Matthew, Cook, Michael, Belouali, Anas, Liu, Stephen V., Madhavan, Subha, He, Aiwu Ruth, Atkins, Michael B., Gibney, Geoffrey T., Kim, Chul

“…BackgroundPatients with chronic viral infections including human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV) are at increased risk of…”
Get full text

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2 by Wong, Shaun D., Srnec, Martin, Matthews, Megan L., Liu, Lei V., Kwak, Yeonju, Park, Kiyoung, Bell III, Caleb B., Alp, E. Ercan, Zhao, Jiyong, Yoda, Yoshitaka, Kitao, Shinji, Seto, Makoto, Krebs, Carsten, Bollinger, J. Martin, Solomon, Edward I.

“…Synchrotron-based nuclear resonance vibrational spectroscopy is used to characterize the reactive Fe( iv )=O intermediate of the halogenase SyrB2; the…”
Get full text

Spreading violaceous neck plaques in a fatigued man by Thompson, H. J., Patrick, A., Liu, V.

“…Click here for the corresponding questions to this CME article…”
Get full text

NSCLC With Synchronous EGFR Mutations in Li Fraumeni Syndrome: A Case Report by Marks, Jennifer A., Liu, Stephen V.

“…We report a case of a patient with Li Fraumeni Syndrome (LFS) who developed synchronous EGFR exon deletion 19 and EGFR exon 20 insertion NSCLC and characterize…”
Get full text

OA1‐AM23‐MN‐23 | Clinical Outcomes in Hospitalized Plasma and Platelet Transfusion Recipients Prior to and Following Periods of Blood Donor SARS‐CoV‐2 Infection and Vaccination by Roubinian, N., Greene, J., Liu, V., Mark, D., Stone, M., Spencer, B., Kleinman, S., Busch, M., Norris, P.

Get full text