Search Results - "Liu, Taoyan"
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Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
Published in Journal of cachexia, sarcopenia and muscle (01-04-2022)“…Age‐associated obesity and muscle atrophy (sarcopenia) are intimately connected and are reciprocally regulated by adipose tissue and skeletal muscle…”
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Uric acid: a potent molecular contributor to pluripotent stem cell cardiac differentiation via mesoderm specification
Published in Cell death and differentiation (01-05-2019)“…Congenital heart disease (CHD) is the most common cause of congenital anomaly and a leading cause of morbidity and mortality worldwide. Generation of…”
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A net-shaped multicellular formation facilitates the maturation of hPSC-derived cardiomyocytes through mechanical and electrophysiological stimuli
Published in Aging (Albany, NY.) (14-04-2018)“…The use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is limited in drug discovery and cardiac disease mechanism studies due to…”
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Muscle Injuries Induce a Prostacyclin‐PPARγ/PGC1a‐FAO Spike That Boosts Regeneration
Published in Advanced science (01-07-2023)“…It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are…”
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Oncofetal SALL4-Driven Tumorigenesis Is Highly Dependent on Oxidative Phosphorylation, Revealing Therapeutic Opportunities
Published in Gastroenterology (New York, N.Y. 1943) (01-12-2019)Get full text
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XAI-enabled neural network analysis of metabolite spatial distributions
Published in Analytical and bioanalytical chemistry (01-06-2023)“…We used deep neural networks to process the mass spectrometry imaging (MSI) data of mouse muscle (young vs aged) and human cancer (tumor vs normal adjacent)…”
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A multi-tissue metabolome atlas of primate pregnancy
Published in Cell (01-02-2024)“…Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this metabolic reprogramming remain poorly understood, especially in primates…”
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Doxorubicin‐induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes
Published in Journal of cellular and molecular medicine (01-07-2019)“…Doxorubicin (DOX) is widely used to treat various cancers affecting adults and children; however, its clinical application is limited by its cardiotoxicity…”
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Spatial metabolomics reveals skeletal myofiber subtypes
Published in Science advances (03-02-2023)“…Skeletal muscle myofibers are heterogeneous in their metabolism. However, metabolomic profiling of single myofibers has remained difficult. Mass spectrometry…”
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AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation‐associated AMPKα1 activation
Published in Journal of cellular and molecular medicine (01-03-2019)“…Tissue damage and its associated‐inflammation act as tumour initiators or propagators. AMP‐activated protein kinase (AMPK) is activated by environmental or…”
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Microscale grooves regulate maturation development of hPSC‐CMs by the transient receptor potential channels (TRP channels)
Published in Journal of cellular and molecular medicine (01-04-2021)“…The use of human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) is limited in drug discovery and cardiac disease mechanism studies due to cell…”
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