Search Results - "Liu, Shumeng"
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BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer
Published in Proceedings of the National Academy of Sciences - PNAS (08-02-2022)“…BRD4 is well known for its role in super-enhancer organization and transcription activation of several prominent oncogenes including and As such, BRD4…”
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Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis
Published in Molecular cell (07-09-2017)“…Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with active transcription in mammalian cells. Here we report that the…”
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Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation
Published in Nature communications (08-12-2022)“…How the carbohydrate binding protein galectin-3 might act as a diabetogenic and tumorogenic factor remains to be investigated. Here we report that…”
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4
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation
Published in PLoS biology (01-03-2014)“…Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular…”
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CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
Published in Nature communications (25-08-2017)“…Impairment of intrinsic plasticity is involved in a range of neurological disorders such as epilepsy. However, how intrinsic excitability is regulated is still…”
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The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry
Published in Signal transduction and targeted therapy (03-11-2021)“…The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation of the…”
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Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis
Published in Cell research (01-09-2018)“…Hyperactivation of EGFR/PI3K/AKT is a prominent feature of various human cancers. Thus, understanding how this molecular cascade is balanced is of great…”
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Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering
Published in Nature genetics (01-09-2016)“…Yongfeng Shang and colleagues report that the pioneering factor FOXA1 associates with DNA repair complexes and regulates DNA demethylation at its genomic…”
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JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component
Published in Molecular cancer (29-11-2017)“…Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75%…”
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UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1
Published in Molecular cell (15-07-2021)“…The transition of oxidized 5-methylcytosine (5mC) intermediates into the base excision repair (BER) pipeline to complete DNA demethylation remains enigmatic…”
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ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
Published in Nature communications (25-09-2017)“…EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism…”
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12
Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks
Published in Journal of molecular cell biology (01-06-2017)“…Faithful transmission or restoration of epigenetic information such as repressive histone modifications through generations is crit- ical for the maintenance…”
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13
Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly
Published in The Journal of biological chemistry (03-11-2017)“…The de novo assembly and post-splicing reassembly of the U4/U6.U5 tri-snRNP remain to be investigated. We report here that ZIP, a protein containing a…”
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14
Analysis of nitrification efficiency and microbial community in a membrane bioreactor fed with low COD/N-ratio wastewater
Published in PloS one (07-05-2013)“…In this study, an approach using influent COD/N ratio reduction was employed to improve process performance and nitrification efficiency in a membrane…”
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15
Temporal variations of cathode performance in air-cathode single-chamber microbial fuel cells with different separators
Published in Journal of power sources (25-12-2014)“…An ideal separator is essential for efficient power production from air-cathode single-chamber microbial fuel cells (MFCs). In this study, we use different…”
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Enhanced TC degradation by persulfate activation with carbon-coated CuFe2O4: The radical and non-radical co-dominant mechanism, DFT calculations and toxicity evaluation
Published in Journal of hazardous materials (05-01-2024)“…Facing the constraints of critical agglomeration and poor reusability of CuFe2O4 in catalytic applications, the feasibility of synthesizing a composite…”
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The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer
Published in The Journal of clinical investigation (01-09-2017)“…The pathophysiological function of the forkhead transcription factor FOXN3 remains to be explored. Here we report that FOXN3 is a transcriptional repressor…”
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Adaptive Resolution Imaging Algorithm for Helicopter-Borne Arc Antenna Array Based on Grid Layout Optimization
Published in 2022 14th International Conference on Signal Processing Systems (ICSPS) (01-11-2022)“…The imaging of arc array radar is complicated due to its special structure. Backward projection (BP) is a high-resolution imaging algorithm, which can solve…”
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Conference Proceeding -
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Kaempferol-3-O-sophoroside (PCS-1) contributes to modulation of depressive-like behaviour in C57BL/6J mice by activating AMPK
Published in British journal of pharmacology (01-04-2024)“…Kaempferol-3-O-sophoroside (PCS-1) is the main component in Crocus sativus (Saffron), a herb with mood-enhancing properties. AMP-activated protein kinase…”
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Advances in research on petroleum biodegradability in soil
Published in Environmental science--processes & impacts (04-02-2021)“…With the increased demand for petroleum and petroleum products from all parts of the society, environmental pollution caused by petroleum development and…”
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