Search Results - "Liu, Rong‐jian"

N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects by Fogaça, Manoela V, Fukumoto, Kenichi, Franklin, Tina, Liu, Rong-Jian, Duman, Catharine H, Vitolo, Ottavio V, Duman, Ronald S

“…Currently available antidepressants have a delayed onset and limited efficacy, highlighting the need for new, rapid and more efficacious agents. Ketamine, an…”
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Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine by Fukumoto, Kenichi, Fogaça, Manoela V., Liu, Rong-Jian, Duman, Catharine, Kato, Taro, Li, Xiao-Yuan, Duman, Ronald S.

“…Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid and long-lasting antidepressant effects in major depressive disorder…”
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Cell-type specific modulation of NMDA receptors triggers antidepressant actions by Pothula, Santosh, Kato, Taro, Liu, Rong-Jian, Wu, Min, Gerhard, Danielle, Shinohara, Ryota, Sliby, Alexa-Nicole, Chowdhury, Golam M. I., Behar, Kevin L., Sanacora, Gerard, Banerjee, Pradeep, Duman, Ronald S.

“…Both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can exert rapid antidepressant effects as shown in several animal and human…”
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Signaling pathways underlying the rapid antidepressant actions of ketamine by Duman, Ronald S., Li, Nanxin, Liu, Rong-Jian, Duric, Vanja, Aghajanian, George

“…Currently available medications have significant limitations, most notably low response rate and time lag for treatment response. Recent clinical studies have…”
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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists by Li, Nanxin, Lee, Boyoung, Liu, Rong-Jian, Banasr, Mounira, Dwyer, Jason M., Iwata, Masaaki, Li, Xiao-Yuan, Aghajanian, George, Duman, Ronald S.

“…The rapid antidepressant response after ketamine administration in treatment-resistant depressed patients suggests a possible new approach for treating mood…”
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Glutamate N -methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure by Li, Nanxin, Liu, Rong-Jian, Dwyer, Jason M, Banasr, Mounira, Lee, Boyoung, Son, Hyeon, Li, Xiao-Yuan, Aghajanian, George, Duman, Ronald S

“…Background Despite widely reported clinical and preclinical studies of rapid antidepressant actions of glutamate N -methyl-D-aspartate (NMDA) receptor…”
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Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy by Liu, Rong-Jian, Aghajanian, George K

“…Morphological studies show that repeated restraint stress leads to selective atrophy in the apical dendritic field of pyramidal cells in the medial prefrontal…”
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Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex by Liu, Rong-Jian, Lee, Francis S, Li, Xiao-Yuan, Bambico, Francis, Duman, Ronald S, Aghajanian, George K

“…Background Knock-in mice with the common human brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have impaired trafficking of BDNF messenger RNA…”
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Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses by Voleti, Bhavya, Navarria, Andrea, Liu, Rong-Jian, Banasr, Mounira, Li, Nanxin, Terwilliger, Rose, Sanacora, Gerard, Eid, Tore, Aghajanian, George, Duman, Ronald S

“…Background Clinical studies report that scopolamine, an acetylcholine muscarinic receptor antagonist, produces rapid antidepressant effects in depressed…”
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Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation by Fukumoto Kenichi, Fogaça Manoela V, Rong-Jian, Liu, Duman, Catharine H, Xiao-Yuan, Li, Chaki Shigeyuki, Duman, Ronald S

“…We previously reported that the serotonergic system is important for the antidepressant-like effects of ketamine, a non-competitive N-methyl-D-aspartate…”
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GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine by LIU, Rong-Jian, FUCHIKAMI, Manabu, DWYER, Jason M, LEPACK, Ashley E, DUMAN, Ronald S, AGHAJANIAN, George K

“…A single dose of the short-acting NMDA antagonist ketamine produces rapid and prolonged antidepressant effects in treatment-resistant patients with major…”
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Positive modulation of NMDA receptors by AGN-241751 exerts rapid antidepressant-like effects via excitatory neurons by Pothula, Santosh, Liu, Rong-Jian, Wu, Min, Sliby, Alexa-Nicole, Picciotto, Marina R, Banerjee, Pradeep, Duman, Ronald S

“…Dysregulation of the glutamatergic system and its receptors in medial prefrontal cortex (mPFC) has been implicated in major depressive disorder. Recent…”
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Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents by Ghosal, Sriparna, Duman, Catharine H., Liu, Rong-Jian, Wu, Min, Terwilliger, Rosemarie, Girgenti, Matthew J., Wohleb, Eric, Fogaca, Manoela V., Teichman, Emily M., Hare, Brendan, Duman, Ronald S.

“…Dysfunction of medial prefrontal cortex (mPFC) in association with imbalance of inhibitory and excitatory neurotransmission has been implicated in depression…”
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Lentivirus‐Mediated Overexpression of MicroRNA‐210 Improves Long‐Term Outcomes after Focal Cerebral Ischemia in Mice by Zeng, Li‐Li, He, Xiao‐Song, Liu, Jian‐Rong, Zheng, Chao‐Bo, Wang, Yong‐Ting, Yang, Guo‐Yuan

“…Summary Aims MicroRNAs play an important role in the pathogenesis of ischemic brain injury and in the repair process during postischemic condition. However,…”
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Dopamine D2L Receptor Deficiency Alters Neuronal Excitability and Spine Formation in Mouse Striatum by Govindaiah, Gubbi, Liu, Rong-Jian, Wang, Yanyan

“…The striatum contains several types of neurons including medium spiny projection neurons (MSNs), cholinergic interneurons (ChIs), and fast-spiking interneurons…”
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Bone marrow mesenchymal stem cells ameliorate hepatic ischemia/reperfusion injuries via inactivation of the MEK/ERK signaling pathway in rats by Pan, Guo-zheng, MD, Yang, Yang, MD, Zhang, Jian, MD, Liu, Wei, PhD, Wang, Guo-ying, MD, Zhang, Ying-cai, MD, Yang, Qing, MM, Zhai, Feng-xian, MD, Tai, Yan, MM, Liu, Jian-rong, MM, Zhang, Qi, MD, PhD, Chen, Gui-hua, MD

“…Abstract Background Primary graft dysfunction or nonfunction after liver transplantation, which is usually caused by ischemia/reperfusion injury (IRI), is a…”
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Inflammatory myofibroblastic tumor diagnosed due to high intraocular pressure by Zhu, Juan, Liu, Hong-Lei, Liu, Hui, Li, Gang, Liu, Jian-Rong, Wang, Wei-Wei

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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation by Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H., Terwilliger, Rosemarie, Vlasuk, George P., Saiah, Eddine, Hahm, Seung, Duman, Ronald S.

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Hypocretins (Orexins) Regulate Serotonin Neurons in the Dorsal Raphe Nucleus by Excitatory Direct and Inhibitory Indirect Actions by Liu, Rong-Jian, van den Pol, Anthony N, Aghajanian, George K

“…The hypocretins (hcrt1 and hcrt2) are expressed by a discrete population of hypothalamic neurons projecting to many regions of the CNS, including the dorsal…”
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An unusual case of malignant glaucoma with ciliary detachment by Xu, Qian-Qian, Wang, Wei-Wei, Zhu, Juan, Liu, Jian-Rong

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