Search Results - "Liu, R"

Base editing: precision chemistry on the genome and transcriptome of living cells by Rees, Holly A., Liu, David R.

“…RNA-guided programmable nucleases from CRISPR systems generate precise breaks in DNA or RNA at specified positions. In cells, this activity can lead to changes…”
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Prime editing for precise and highly versatile genome manipulation by Chen, Peter J., Liu, David R.

“…Programmable gene-editing tools have transformed the life sciences and have shown potential for the treatment of genetic disease. Among the CRISPR–Cas…”
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Rewritable multi-event analog recording in bacterial and mammalian cells by Tang, Weixin, Liu, David R

“…We present two CRISPR-mediated analog multi-event recording apparatus (CAMERA) systems that use base editors and Cas9 nucleases to record cellular events in…”
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Methods for the directed evolution of proteins by Packer, Michael S., Liu, David R.

“…Key Points Directed evolution is a cyclic process that alternates between gene diversification and screening for or selection of functional gene variants…”
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Oxidative stress and glutathione in TGF-β-mediated fibrogenesis by Liu, R.-M., Gaston Pravia, K.A.

“…Transforming growth factor β (TGF-β) is the most potent and ubiquitous profibrogenic cytokine, and its expression is increased in almost all the fibrotic…”
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CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes by Komor, Alexis C., Badran, Ahmed H., Liu, David R.

“…The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes…”
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Smoothed Finite Element Methods (S-FEM): An Overview and Recent Developments by Zeng, W., Liu, G. R.

“…The smoothed finite element methods (S-FEM) are a family of methods formulated through carefully designed combinations of the standard FEM and some of the…”
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Inflammation and intracellular metabolism: new targets in OA by Liu-Bryan, R

“…Summary Articular cartilage degeneration is hallmark of osteoarthritis (OA). Low-grade chronic inflammation in the joint can promote OA progression. Emerging…”
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Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification by Guilinger, John P, Thompson, David B, Liu, David R

“…A fusion of the FokI nuclease and a catalytically inactive Cas9 is a highly specific genome editing tool. Genome editing by Cas9, which cleaves double-stranded…”
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On-Demand Semiconductor Source of Entangled Photons Which Simultaneously Has High Fidelity, Efficiency, and Indistinguishability by Wang, Hui, Hu, Hai, Chung, T-H, Qin, Jian, Yang, Xiaoxia, Li, J-P, Liu, R-Z, Zhong, H-S, He, Y-M, Ding, Xing, Deng, Y-H, Dai, Qing, Huo, Y-H, Höfling, Sven, Lu, Chao-Yang, Pan, Jian-Wei

“…An outstanding goal in quantum optics and scalable photonic quantum technology is to develop a source that each time emits one and only one entangled photon…”
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A G space theory and a weakened weak (W2) form for a unified formulation of compatible and incompatible methods: Part I theory by Liu, G. R.

“…This paper introduces a G space theory and a weakened weak form (W2) using the generalized gradient smoothing technique for a unified formulation of a wide…”
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Experimental observation of electron–hole recollisions by Zaks, B., Liu, R. B., Sherwin, M. S.

“…High-order-sideband generation by means of electron–hole recollisions in excitons is observed in semiconductor quantum wells. Tearing holes in ultrafast light…”
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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage by Komor, Alexis C., Kim, Yongjoo B., Packer, Michael S., Zuris, John A., Liu, David R.

“…CRISPR/Cas9 DNA editing creates a double-stranded break in the target DNA, which can frequently generate random insertion or deletion of bases (indels); a new…”
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Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation by Tang, Weixin, Hu, Johnny H., Liu, David R.

“…Programmable sequence-specific genome editing agents such as CRISPR-Cas9 have greatly advanced our ability to manipulate the human genome. Although canonical…”
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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity by Pattanayak, Vikram, Lin, Steven, Guilinger, John P, Ma, Enbo, Doudna, Jennifer A, Liu, David R

“…In vitro selection and high-throughput sequencing measure the sequence specificity of cleavage by gRNA-Cas9 complexes. The RNA-programmable Cas9 endonuclease…”
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Proving Nontrivial Topology of Pure Bismuth by Quantum Confinement by Ito, S, Feng, B, Arita, M, Takayama, A, Liu, R-Y, Someya, T, Chen, W-C, Iimori, T, Namatame, H, Taniguchi, M, Cheng, C-M, Tang, S-J, Komori, F, Kobayashi, K, Chiang, T-C, Matsuda, I

“…The topology of pure Bi is controversial because of its very small (∼10  meV) band gap. Here we perform high-resolution angle-resolved photoelectron…”
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Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein by Pak, Chi W., Kosno, Martyna, Holehouse, Alex S., Padrick, Shae B., Mittal, Anuradha, Ali, Rustam, Yunus, Ali A., Liu, David R., Pappu, Rohit V., Rosen, Michael K.

“…Liquid-liquid phase separation, driven by collective interactions among multivalent and intrinsically disordered proteins, is thought to mediate the formation…”
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Sequence-Controlled Polymers by Lutz, Jean-François, Ouchi, Makoto, Liu, David R., Sawamoto, Mitsuo

“…Sequence-controlled polymers are macromolecules in which monomer units of different chemical nature are arranged in an ordered fashion. The most prominent…”
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CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes by Komor, Alexis C., Badran, Ahmed H., Liu, David R.

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Efficiency, effectiveness and treatment stability of clear aligners: A systematic review and meta‐analysis by Zheng, M., Liu, R., Ni, Z., Yu, Z.

“…Structured Objectives The objective of this study was to perform a systematic review of the orthodontic literature with regard to efficiency, effectiveness and…”
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