Search Results - "Liu, Phillip C."

INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models by Liu, Phillip C C, Koblish, Holly, Wu, Liangxing, Bowman, Kevin, Diamond, Sharon, DiMatteo, Darlise, Zhang, Yue, Hansbury, Michael, Rupar, Mark, Wen, Xiaoming, Collier, Paul, Feldman, Patricia, Klabe, Ronald, Burke, Krista A, Soloviev, Maxim, Gardiner, Christine, He, Xin, Volgina, Alla, Covington, Maryanne, Ruggeri, Bruce, Wynn, Richard, Burn, Timothy C, Scherle, Peggy, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Hollis, Gregory

“…Alterations in fibroblast growth factor receptor (FGFR) genes have been identified as potential driver oncogenes. Pharmacological targeting of FGFRs may…”
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Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor by Wu, Liangxing, Zhang, Colin, He, Chunhong, Qian, Dingquan, Lu, Liang, Sun, Yaping, Xu, Meizhong, Zhuo, Jincong, Liu, Phillip C. C, Klabe, Ronald, Wynn, Richard, Covington, Maryanne, Gallagher, Karen, Leffet, Lynn, Bowman, Kevin, Diamond, Sharon, Koblish, Holly, Zhang, Yue, Soloviev, Maxim, Hollis, Gregory, Burn, Timothy C, Scherle, Peggy, Yeleswaram, Swamy, Huber, Reid, Yao, Wenqing

“…Aberrant activation of FGFR has been linked to the pathogenesis of many tumor types. Selective inhibition of FGFR has emerged as a promising approach for…”
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Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast by Batista-Nascimento, Liliana, Neef, Daniel W, Liu, Phillip C C, Rodrigues-Pousada, Claudina, Thiele, Dennis J

“…Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is…”
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Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic (S)-Isothiazolidinone Phosphotyrosine Mimetic by Combs, Andrew P, Zhu, Wenyu, Crawley, Matthew L, Glass, Brian, Polam, Padmaja, Sparks, Richard B, Modi, Dilip, Takvorian, Amy, McLaughlin, Erin, Yue, Eddy W, Wasserman, Zelda, Bower, Michael, Wei, Min, Rupar, Mark, Ala, Paul J, Reid, Brian M, Ellis, Dawn, Gonneville, Lucie, Emm, Thomas, Taylor, Nancy, Yeleswaram, Swamy, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Hollis, Gregory, Liu, Phillip C. C, Metcalf, Brian

“…Potent nonpeptidic benzimidazole sulfonamide inhibitors of protein tyrosine phosphatase 1B (PTP1B) were derived from the optimization of a tripeptide…”
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Benzothiazole benzimidazole ( S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors by Sparks, Richard B., Polam, Padmaja, Zhu, Wenyu, Crawley, Matthew L., Takvorian, Amy, McLaughlin, Erin, Wei, Min, Ala, Paul J., Gonneville, Lucie, Taylor, Nancy, Li, Yanlong, Wynn, Richard, Burn, Timothy C., Liu, Phillip C.C., Combs, Andrew P.

“…Benzothiazole benzimidazole ( S)-isothiazolidinone (( S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide ( S)-IZD…”
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Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines by Douty, Brent, Wayland, Brian, Ala, Paul J., Bower, Michael J., Pruitt, James, Bostrom, Lori, Wei, Min, Klabe, Ronald, Gonneville, Lucie, Wynn, Richard, Burn, Timothy C., Liu, Phillip C.C., Combs, Andrew P., Yue, Eddy W.

“…The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to…”
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Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold by Yue, Eddy W., Wayland, Brian, Douty, Brent, Crawley, Matthew L., McLaughlin, Erin, Takvorian, Amy, Wasserman, Zelda, Bower, Michael J., Wei, Min, Li, Yanlong, Ala, Paul J., Gonneville, Lucie, Wynn, Richard, Burn, Timothy C., Liu, Phillip C.C., Combs, Andrew P.

“…The structure-based design and discovery of the isothiazolidinone (IZD) heterocycle as a mimic of phosphotyrosine (pTyr) has led to the identification of novel…”
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Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor by Koblish, Holly K, Wu, Liangxing, Wang, Liang-Chuan S, Liu, Phillip C C, Wynn, Richard, Rios-Doria, Jonathan, Spitz, Susan, Liu, Hao, Volgina, Alla, Zolotarjova, Nina, Kapilashrami, Kanishk, Behshad, Elham, Covington, Maryanne, Yang, Yan-Ou, Li, Jingwei, Diamond, Sharon, Soloviev, Maxim, O'Hayer, Kevin, Rubin, Stephen, Kanellopoulou, Chrysi, Yang, Gengjie, Rupar, Mark, DiMatteo, Darlise, Lin, Luping, Stevens, Christina, Zhang, Yue, Thekkat, Pramod, Geschwindt, Ryan, Marando, Cindy, Yeleswaram, Swamy, Jackson, Jeff, Scherle, Peggy, Huber, Reid, Yao, Wenqing, Hollis, Gregory

“…Blocking the activity of the programmed cell death protein 1 (PD-1) inhibitory receptor with therapeutic antibodies against either the ligand (PD-L1) or PD-1…”
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Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors by Schafer, Johanna M, Lehmann, Brian D, Gonzalez-Ericsson, Paula I, Marshall, Clayton B, Beeler, J Scott, Redman, Lindsay N, Jin, Hailing, Sanchez, Violeta, Stubbs, Matthew C, Scherle, Peggy, Johnson, Kimberly N, Sheng, Quanhu, Roland, Joseph T, Bauer, Joshua A, Shyr, Yu, Chakravarthy, Bapsi, Mobley, Bret C, Hiebert, Scott W, Balko, Justin M, Sanders, Melinda E, Liu, Phillip C C, Pietenpol, Jennifer A

“…Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that does not respond to endocrine therapy or human epidermal growth factor…”
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Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy by Shin, Niu, Stubbs, Matthew, Koblish, Holly, Yue, Eddy W., Soloviev, Maxim, Douty, Brent, Wang, Kathy He, Wang, Qian, Gao, Mingming, Feldman, Patricia, Yang, Gengjie, Hall, Leslie, Hansbury, Michael, O’Connor, Sybil, Leffet, Lynn, Collins, Robert, Katiyar, Kamna, He, Xin, Waeltz, Paul, Collier, Paul, Lu, Jin, Li, Yun-Long, Li, Yanlong, Liu, Phillip C.C., Burn, Timothy, Covington, Maryanne, Diamond, Sharon, Shuey, Dana, Roberts, Alan, Yeleswaram, Swamy, Hollis, Greg, Metcalf, Brian, Yao, Wenqing, Huber, Reid, Combs, Andrew, Newton, Robert, Scherle, Peggy

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The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies by Stubbs, Matthew C, Burn, Timothy C, Sparks, Richard, Maduskuie, Thomas, Diamond, Sharon, Rupar, Mark, Wen, Xiaoming, Volgina, Alla, Zolotarjova, Nina, Waeltz, Paul, Favata, Margaret, Jalluri, Ravi, Liu, Huiqing, Liu, Xuesong Mike, Li, Jun, Collins, Robert, Falahatpisheh, Nikoo, Polam, Padmaja, DiMatteo, Darlise, Feldman, Patricia, Dostalik, Valerie, Thekkat, Pramod, Gardiner, Christine, He, Xin, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Ruggeri, Bruce, Yeleswaram, Swamy, Xue, Chu-Biao, Yao, Wenqing, Combs, Andrew P, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip C C

“…Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated…”
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Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis by Liu, P C, Thiele, D J

“…Under stressful conditions organisms adjust the synthesis, processing, and trafficking of molecules to allow survival from and recovery after stress. In…”
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Validation of standards for quantitative assessment of JAK2 c.1849G>T (p.V617F) allele burden analysis in clinical samples by Collier, Paul, Patel, Keyur, Waeltz, Paul, Rupar, Mark, Luthra, Rajyalakshmi, Liu, Phillip C C, Hollis, Gregory, Huber, Reid, Verstovsek, Srdan, Burn, Timothy C

“…The substitution of valine with phenylalanine at amino acid 617 of the Janus kinase 2 (JAK2) gene (JAK2 p.V617F) occurs in a high proportion of patients with…”
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BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia by Ramsey, Haley E, Greenwood, Dalton, Zhang, Susu, Childress, Merrida, Arrate, Maria P, Gorska, Agnieszka E, Fuller, Londa, Zhao, Yue, Stengel, Kristy, Fischer, Melissa A, Stubbs, Matthew C, Liu, Phillip C C, Boyd, Kelli, Rathmell, Jeffrey C, Hiebert, Scott W, Savona, Michael R

“…The BCL2 inhibitor, venetoclax, has transformed clinical care in acute myeloid leukemia (AML). However, subsets of patients do not respond or eventually…”
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High-throughput determination of mode of inhibition in lead identification and optimization by Wei, Min, Wynn, Richard, Hollis, Gregory, Liao, Boshan, Margulis, Alexander, Reid, Brian G, Klabe, Ronald, Liu, Phillip C C, Becker-Pasha, Mary, Rupar, Mark, Burn, Timothy C, McCall, Dale E, Li, Yanlong

“…After finishing the primary high-throughput screening, the screening team is often faced with thousands of hits to be evaluated further. Effective filtering of…”
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Efficacy of Novel Bromodomain and Extraterminal Inhibitors in Combination with Chemotherapy for Castration-Resistant Prostate Cancer by Vázquez, Ramiro, Civenni, Gianluca, Kokanovic, Aleksandra, Shinde, Dheeraj, Cantergiani, Jasmine, Marchetti, Martina, Zoppi, Giada, Ruggeri, Bruce, Liu, Phillip C.C., Carbone, Giuseppina M., Catapano, Carlo V.

“…Chemotherapy is the treatment of choice for metastatic castration-resistant prostate cancer (mCRPC) nonresponsive to androgen receptor–targeted therapies…”
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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells by Liu, Phillip C.C., Liu, Xiangdong, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Huber, Reid, Hillman, Milton, Yang, Gengjie, Ellis, Dawn, Marando, Cindy, Katiyar, Kamna, Bradley, Jodi, Abremski, Kenneth, Stow, Mark, Rupar, Mark, Zhuo, Jincong, Li, Yun-Long, Lin, Qiyan, Burns, David, Xu, Meizhong, Zhang, Colin, Qian, Ding-Quan, He, Chunhong, Sharief, Vaqar, Weng, Lingkai, Agrios, Costas, Shi, Eric, Metcalf, Brian, Newton, Robert, Friedman, Steven, Yao, Wenqing, Scherle, Peggy A., Hollis, Gregory, Burn, Timothy C.

“…ALL AUTHORS: Phillip C.C. Liu, Xiangdong Liu, Yanlong Li, Maryanne Covington, Richard Wynn, Reid Huber, Milton Hillman, Gengjie Yang, Dawn Ellis, Cindy…”
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Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity by Liu, Phillip C C, Caulder, Eian, Li, Jun, Waeltz, Paul, Margulis, Alex, Wynn, Richard, Becker-Pasha, Mary, Li, Yanlong, Crowgey, Erin, Hollis, Gregory, Haley, Patrick, Sparks, Richard B, Combs, Andrew P, Rodgers, James D, Burn, Timothy C, Vaddi, Kris, Fridman, Jordan S

“…Purpose: Deregulation of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway is a hallmark for the Philadelphia…”
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Abstract 3780: Activity of the BET inhibitor INCB054329 in models of lymphoma by Stubbs, Matthew, Collins, Robert, Volgina, Alla, Liu, Mike, Favata, Margaret, Rupar, Mark, Wen, Xiaomng, Sparks, Richard, Maduskuie, Thomas, Covington, Maryanne, Burn, Timothy, Ruggeri, Bruce, Combs, Andrew P., Yao, Wenqing, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip CC

“…Inhibitors of the BET family of Bromodomain proteins have been shown to be growth inhibitory across a spectrum of tumor types due to their ability to regulate…”
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Induction of endogenous genes by peroxisome proliferator activated receptor alpha ligands in a human kidney cell line and in vivo by Liu, Phillip C.C., Huber, Reid, Stow, Mark D., Schlingmann, Karen L., Collier, Paul, Liao, Boshan, Link, John, Burn, Tim C., Hollis, Greg, Young, Peter R., Mukherjee, Ranjan

“…The peroxisome proliferator activated receptor alpha (PPARα) plays a key role in regulating fatty acid metabolism by regulating expression of genes involved in…”
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