Search Results - "Liu, Philip B."

Metabolomic prediction of fetal congenital heart defect in the first trimester by Bahado-Singh, Ray O., MD, MBA, Ertl, Rebecca, MD, Mandal, Rupasri, PhD, Bjorndahl, Trent C., PhD, Syngelaki, Argyro, Han, Beomsoo, PhD, Dong, Edison, BSc, Liu, Philip B., BSc, Alpay-Savasan, Zeynep, Wishart, David S., PhD, Nicolaides, Kypros H., MD

“…Objective The objective of the study was to identify metabolomic markers in maternal first-trimester serum for the detection of fetal congenital heart defects…”
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Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction by Mahmud, Zabed, Tikunova, Svetlana, Belevych, Natalya, Wagg, Cory S, Zhabyeyev, Pavel, Liu, Philip B, Rasicci, David V, Yengo, Christopher M, Oudit, Gavin Y, Lopaschuk, Gary D, Reiser, Peter J, Davis, Jonathan P, Hwang, Peter M

“…Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small…”
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The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C by Li, Monica X., Gelozia, Shorena, Danmaliki, Gaddafi I., Wen, Yurong, Liu, Philip B., Lemieux, M. Joanne, West, Frederick G., Sykes, Brian D., Hwang, Peter M.

“…The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate…”
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Structure and activation mechanism of Staphylococcus aureus response regulator ArlR by solution NMR by Rafid Feisal, Mohammad, Liu, Philip B., Wen, Yurong, Hwang, Peter M.

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Dilated Cardiomyopathy Mutations and Phosphorylation disrupt the Active Orientation of Cardiac Troponin C by Mahmud, Zabed, Dhami, Prabhpaul S., Rans, Caleb, Liu, Philip B., Hwang, Peter M.

“…[Display omitted] •The cardiac troponin complex can adopt an active or dormant orientation.•Competing orientations of troponin regulate cardiac muscle calcium…”
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Probing amino acid side chains of the integral membrane protein PagP by solution NMR: Side chain immobilization facilitates association of secondary structures by Goel, Shaista, Feisal, M. Rafid, Danmaliki, Gaddafi I., Yu, Shaohui, Liu, Philip B., Bishop, Russell E., West, Frederick G., Hwang, Peter M.

“…Solution NMR spectroscopy of large protein systems is hampered by rapid signal decay, so most multidimensional studies focus on long-lived 1H-13C magnetization…”
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Solution NMR studies reveal novel CLIC4 chaperone activity with respect to profilin-1 by Mak, Kevin Y., Feisal, M. Rafid, Mahmud, Zabed, Liu, Philip B., Li, Laiji, Luo, Shu Y., Julien, Olivier, Schulz, Richard, Ballermann, Barbara J., Hwang, Peter M.

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Stereoselective Deuteration in Aspartate, Asparagine, Lysine, and Methionine Amino Acid Residues Using Fumarate as a Carbon Source for Escherichia coli in D2O by Danmaliki, Gaddafi I, Liu, Philip B, Hwang, Peter M

“…Perdeuteration with selective 1H,13C-enrichment of methyl groups has enabled solution NMR studies of large (>30 kDa) protein systems. However, we propose that…”
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RPI‐194 is a Novel Troponin Activator that Increases the Calcium Sensitivity of Striated Muscle Contraction by Mahmud, Zabed, Tikunova, Svetlana, Belevych, Natalya, Wagg, Corey, Zhabyeyev, Pavel, Liu, Philip B., Rasicci, David V., Schulz, Richard, Yengo, Christopher M., Oudit, Gavin Y., Lopaschuk, Gary D., Reiser, Peter J., Davis, Jonathan P., Hwang, Peter M.

“…Introduction Systolic heart failure is a cardiac disease in which the contractile function of heart muscle becomes weakened and unable to pump blood with…”
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Stereoselective Deuteration in Aspartate, Asparagine, Lysine, and Methionine Amino Acid Residues Using Fumarate as a Carbon Source for Escherichia coli in D 2 O by Danmaliki, Gaddafi I, Liu, Philip B, Hwang, Peter M

“…Perdeuteration with selective H, C-enrichment of methyl groups has enabled solution NMR studies of large (>30 kDa) protein systems. However, we propose that…”
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Structure and proteolytic susceptibility of the inhibitory C-terminal tail of cardiac troponin I by Mahmud, Zabed, Zahran, Somaya, Liu, Philip B., Reiz, Bela, Chan, Brandon Y.H., Roczkowsky, Andrej, McCartney, Christian-Scott E., Davies, Peter L., Li, Liang, Schulz, Richard, Hwang, Peter M.

“…Cardiac troponin I (cTnI) has two flexible tails that control the cardiac cycle. The C-terminal tail, cTnI135–209, binds actin to shut off cardiac muscle…”
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Combining a PagP fusion protein system with nickel ion-catalyzed cleavage to produce intrinsically disordered proteins in E. coli by Zahran, Somaya, Pan, Jonathan S., Liu, Philip B., Hwang, Peter M.

“…•We present a new strategy for overproducing intrinsically disordered proteins.•PagP directs proteins into inclusion bodies as an N- or C-terminal fusion…”
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Metabolomic Prediction of Fetal Congenital Heart Defect in the First Trimester by Bahado-Singh, Ray O, Ertl, Rebecca, Mandal, Rupasri, Bjorndahl, Trent C, Syngelaki, Argyro, Han, Beomsoo, Dong, Edison, Liu, Philip B, Alpay-Savasan, Zeynep, Wishart, David S, Nicolaides, Kypros H

“…ABSTRACTCongenital heart defects (CHDs) are the most important category of congenital anomalies, based on their frequency, potential severity, and health care…”
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