Search Results - "Liu, Paul P"

Low Incidence of DNA Sequence Variation in Human Induced Pluripotent Stem Cells Generated by Nonintegrating Plasmid Expression by Cheng, Linzhao, Hansen, Nancy F., Zhao, Ling, Du, Yutao, Zou, Chunlin, Donovan, Frank X., Chou, Bin-Kuan, Zhou, Guangyu, Li, Shijie, Dowey, Sarah N., Ye, Zhaohui, Chandrasekharappa, Settara C., Yang, Huanming, Mullikin, James C., Liu, P. Paul

“…The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes…”
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Gain-of-Function Pyrin Mutations Induce NLRP3 Protein -Independent Interleukin-1β Activation and Severe Autoinflammation in Mice by Chae, Jae Jin, Cho, Young-Hun, Lee, Geun-Shik, Cheng, Jun, Liu, P. Paul, Feigenbaum, Lionel, Katz, Stephen I., Kastner, Daniel L.

“…Missense mutations in the C-terminal B30.2 domain of pyrin cause familial Mediterranean fever (FMF), the most common Mendelian autoinflammatory disease…”
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Genetic regulation of the RUNX transcription factor family has antitumor effects by Morita, Ken, Suzuki, Kensho, Maeda, Shintaro, Matsuo, Akihiko, Mitsuda, Yoshihide, Tokushige, Chieko, Kashiwazaki, Gengo, Taniguchi, Junichi, Maeda, Rina, Noura, Mina, Hirata, Masahiro, Kataoka, Tatsuki, Yano, Ayaka, Yamada, Yoshimi, Kiyose, Hiroki, Tokumasu, Mayu, Matsuo, Hidemasa, Tanaka, Sunao, Okuno, Yasushi, Muto, Manabu, Naka, Kazuhito, Ito, Kosei, Kitamura, Toshio, Kaneda, Yasufumi, Liu, Paul P, Bando, Toshikazu, Adachi, Souichi, Sugiyama, Hiroshi, Kamikubo, Yasuhiko

“…Runt-related transcription factor 1 (RUNX1) is generally considered to function as a tumor suppressor in the development of leukemia, but a growing body of…”
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miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia by Jiang, Xi, Hu, Chao, Arnovitz, Stephen, Bugno, Jason, Yu, Miao, Zuo, Zhixiang, Chen, Ping, Huang, Hao, Ulrich, Bryan, Gurbuxani, Sandeep, Weng, Hengyou, Strong, Jennifer, Wang, Yungui, Li, Yuanyuan, Salat, Justin, Li, Shenglai, Elkahloun, Abdel G., Yang, Yang, Neilly, Mary Beth, Larson, Richard A., Le Beau, Michelle M., Herold, Tobias, Bohlander, Stefan K., Liu, Paul P., Zhang, Jiwang, Li, Zejuan, He, Chuan, Jin, Jie, Hong, Seungpyo, Chen, Jianjun

“…MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic…”
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Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells by Goyama, Susumu, Schibler, Janet, Cunningham, Lea, Zhang, Yue, Rao, Yalan, Nishimoto, Nahoko, Nakagawa, Masahiro, Olsson, Andre, Wunderlich, Mark, Link, Kevin A, Mizukawa, Benjamin, Grimes, H Leighton, Kurokawa, Mineo, Liu, P Paul, Huang, Gang, Mulloy, James C

“…RUNX1 is generally considered a tumor suppressor in myeloid neoplasms. Inactivating RUNX1 mutations have frequently been found in patients with myelodysplastic…”
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Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia by Jiang, Xi, Huang, Hao, Li, Zejuan, Li, Yuanyuan, Wang, Xiao, Gurbuxani, Sandeep, Chen, Ping, He, Chunjiang, You, Dewen, Zhang, Shuodan, Wang, Jinhua, Arnovitz, Stephen, Elkahloun, Abdel, Price, Colles, Hong, Gia-Ming, Ren, Haomin, Kunjamma, Rejani B., Neilly, Mary Beth, Matthews, Jonathan M., Xu, Mengyi, Larson, Richard A., Le Beau, Michelle M., Slany, Robert K., Liu, Paul P., Lu, Jun, Zhang, Jiwang, He, Chuan, Chen, Jianjun

“…Expression of microRNAs (miRNAs) is under stringent regulation at both transcriptional and posttranscriptional levels. Disturbance at either level could cause…”
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TET1 plays an essential oncogenic role in MLL-rearranged leukemia by Huang, Hao, Jiang, Xi, Li, Zejuan, Li, Yuanyuan, Song, Chun-Xiao, He, Chunjiang, Sun, Miao, Chen, Ping, Gurbuxani, Sandeep, Wang, Jiapeng, Hong, Gia-Ming, Elkahloun, Abdel G., Arnovitz, Stephen, Wang, Jinhua, Szulwach, Keith, Lin, Li, Street, Craig, Wunderlich, Mark, Dawlaty, Meelad, Neilly, Mary Beth, Jaenisch, Rudolf, Yang, Feng-Chun, Mulloy, James C., Jin, Peng, Liu, Paul P., Rowley, Janet D., Xu, Mingjiang, He, Chuan, Chen, Jianjun

“…The ten-eleven translocation 1 (TET1) gene is the founding member of the TET family of enzymes (TET1/2/3) that convert 5-methylcytosine to…”
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An efficient dissociation protocol for generation of single cell suspension from zebrafish embryos and larvae by Bresciani, Erica, Broadbridge, Elizabeth, Liu, Paul P.

“…[Display omitted] Zebrafish (Danio rerio) has emerged as a powerful animal model to study developmental processes and human diseases. The introduction of…”
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Identification of a 24-Gene Prognostic Signature That Improves the European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: An International Collaborative Study by Li, Zejuan, Herold, Tobias, He, Chunjiang, Valk, Peter J M, Chen, Ping, Jurinovic, Vindi, Mansmann, Ulrich, Radmacher, Michael D, Maharry, Kati S, Sun, Miao, Yang, Xinan, Huang, Hao, Jiang, Xi, Sauerland, Maria-Cristina, Büchner, Thomas, Hiddemann, Wolfgang, Elkahloun, Abdel, Neilly, Mary Beth, Zhang, Yanming, Larson, Richard A, Le Beau, Michelle M, Caligiuri, Michael A, Döhner, Konstanze, Bullinger, Lars, Liu, Paul P, Delwel, Ruud, Marcucci, Guido, Lowenberg, Bob, Bloomfield, Clara D, Rowley, Janet D, Bohlander, Stefan K, Chen, Jianjun

“…To identify a robust prognostic gene expression signature as an independent predictor of survival of patients with acute myeloid leukemia (AML) and use it to…”
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Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects by Connelly, Jon P., Kwon, Erika M., Gao, Yongxing, Trivedi, Niraj S., Elkahloun, Abdel G., Horwitz, Marshall S., Cheng, Linzhao, Liu, P. Paul

“…Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disease of the hematopoietic system that is caused…”
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Overexpression and knockout of miR-126 both promote leukemogenesis by Li, Zejuan, Chen, Ping, Su, Rui, Li, Yuanyuan, Hu, Chao, Wang, Yungui, Arnovitz, Stephen, He, Miao, Gurbuxani, Sandeep, Zuo, Zhixiang, Elkahloun, Abdel G., Li, Shenglai, Weng, Hengyou, Huang, Hao, Neilly, Mary Beth, Wang, Shusheng, Olson, Eric N., Larson, Richard A., Le Beau, Michelle M., Zhang, Jiwang, Jiang, Xi, Wei, Minjie, Jin, Jie, Liu, Paul P., Chen, Jianjun

“…It is generally assumed that gain- and loss-of-function manipulations of a functionally important gene should lead to the opposite phenotypes. We show in this…”
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PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease by Li, Zejuan, Chen, Ping, Su, Rui, Hu, Chao, Li, Yuanyuan, Elkahloun, Abdel G, Zuo, Zhixiang, Gurbuxani, Sandeep, Arnovitz, Stephen, Weng, Hengyou, Wang, Yungui, Li, Shenglai, Huang, Hao, Neilly, Mary Beth, Wang, Gang Greg, Jiang, Xi, Liu, Paul P, Jin, Jie, Chen, Jianjun

“…Overexpression of HOXA/MEIS1/PBX3 homeobox genes is the hallmark of mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML). HOXA9 and MEIS1 are…”
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Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia by Jiang, Xi, Hu, Chao, Ferchen, Kyle, Nie, Ji, Cui, Xiaolong, Chen, Chih-Hong, Cheng, Liting, Zuo, Zhixiang, Seibel, William, He, Chunjiang, Tang, Yixuan, Skibbe, Jennifer R., Wunderlich, Mark, Reinhold, William C., Dong, Lei, Shen, Chao, Arnovitz, Stephen, Ulrich, Bryan, Lu, Jiuwei, Weng, Hengyou, Su, Rui, Huang, Huilin, Wang, Yungui, Li, Chenying, Qin, Xi, Mulloy, James C., Zheng, Yi, Diao, Jiajie, Jin, Jie, Li, Chong, Liu, Paul P., He, Chuan, Chen, Yuan, Chen, Jianjun

“…Effective therapy of acute myeloid leukemia (AML) remains an unmet need. DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1) is a critical…”
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PBX3 is an important cofactor of HOXA9 in leukemogenesis by Li, Zejuan, Zhang, Zhiyu, Li, Yuanyuan, Arnovitz, Stephen, Chen, Ping, Huang, Hao, Jiang, Xi, Hong, Gia-Ming, Kunjamma, Rejani B., Ren, Haomin, He, Chunjiang, Wang, Chong-Zhi, Elkahloun, Abdel G., Valk, Peter J.M., Döhner, Konstanze, Neilly, Mary Beth, Bullinger, Lars, Delwel, Ruud, Löwenberg, Bob, Liu, Paul P., Morgan, Richard, Rowley, Janet D., Yuan, Chun-Su, Chen, Jianjun

“…Although PBX proteins are known to increase DNA-binding/transcriptional activity of HOX proteins through their direct binding, the functional importance of…”
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miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia–rearranged leukemia by Chen, Ping, Price, Colles, Li, Zejuan, Li, Yuanyuan, Cao, Donglin, Wiley, Anissa, He, Chunjiang, Gurbuxani, Sandeep, Kunjamma, Rejani B., Huang, Hao, Jiang, Xi, Arnovitz, Stephen, Xu, Mengyi, Hong, Gia-Ming, Elkahloun, Abdel G., Neilly, Mary Beth, Wunderlich, Mark, Larson, Richard A., Le Beau, Michelle M., Mulloy, James C., Liu, Paul P., Rowley, Janet D., Chen, Jianjun

“…MicroRNAs (miRNAs), small noncoding RNAs that regulate target gene mRNAs, are known to contribute to pathogenesis of cancers. Acute myeloid leukemia (AML) is a…”
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Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression by Jin, Hao, Li, Li, Xu, Jin, Zhen, Fenghua, Zhu, Lu, Liu, P. Paul, Zhang, Mingjie, Zhang, Wenqing, Wen, Zilong

“…Proper cell fate choice in myelopoiesis is essential for generating correct numbers of distinct myeloid subsets manifesting a wide spectrum of subset-specific…”
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Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI by Jin, Hao, Sood, Raman, Xu, Jin, Zhen, Fenghua, English, Milton A, Liu, P Paul, Wen, Zilong

“…One unique feature of vertebrate definitive hematopoiesis is the ontogenic switching of hematopoietic stem cells from one anatomical compartment or niche to…”
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Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia by Mi, Shuangli, Li, Zejuan, Chen, Ping, He, Chunjiang, Cao, Donglin, Elkahloun, Abdel, Lu, Jun, Pelloso, Luis A, Wunderlich, Mark, Huang, Hao, Luo, Roger T, Sun, Miao, He, Miao, Neilly, Mary Beth, Zeleznik-Le, Nancy J, Thirman, Michael J, Mulloy, James C, Liu, Paul P, Rowley, Janet D, Chen, Jianjun

“…MicroRNA (miRNA)-17-92 cluster (miR-17-92), containing seven individual miRNAs, is frequently amplified and overexpressed in lymphomas and various solid…”
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Targeted Disruption of Pyrin, the FMF Protein, Causes Heightened Sensitivity to Endotoxin and a Defect in Macrophage Apoptosis by Chae, Jae Jin, Komarow, Hirsh D., Cheng, Jun, Wood, Geryl, Raben, Nina, Liu, P. Paul, Kastner, Daniel L.

“…Familial Mediterranean fever (FMF) is an inherited disorder characterized by recurrent episodes of fever and inflammation. Most patients with FMF carry…”
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Increased Activity of Hypoxia-Inducible Factor 1 Is Associated with Early Embryonic Lethality in Commd1 Null Mice by van de Sluis, Bart, Muller, Patricia, Duran, Karen, Chen, Amy, Groot, Arjan J., Klomp, Leo W., Liu, Paul P., Wijmenga, Cisca

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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